Natalie Mitchell
A5017722474- Sepsis Diagnosis and Treatment
- Celiac Disease Research and Management
- Drilling and Well Engineering
- Microscopic Colitis
- Drug-Induced Hepatotoxicity and Protection
- Metabolomics and Mass Spectrometry Studies
- Cardiac, Anesthesia and Surgical Outcomes
- CO2 Sequestration and Geologic Interactions
- Genomics and Chromatin Dynamics
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Inflammatory Bowel Disease
- Metastasis and carcinoma case studies
- Cancer-related gene regulation
- Cardiac Arrest and Resuscitation
- Epigenetics and DNA Methylation
- Global Health and Surgery
- Intensive Care Unit Cognitive Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Diverticular Disease and Complications
- Parvovirus B19 Infection Studies
- Dermatological and COVID-19 studies
- Community Development and Social Impact
- Adrenal Hormones and Disorders
- Post-Soviet Geopolitical Dynamics
University of Rochester Medical Center
2024
Rice University
2023
Joint Base San Antonio
2021-2022
Brooke Army Medical Center
2021-2022
Wilford Hall Ambulatory Surgical Center
2022
De Montfort University
2022
Walter Reed National Military Medical Center
2017-2020
NIHR Surgical Reconstruction and Microbiology Research Centre
2016
UCB Pharma (United Kingdom)
2015
University of Alabama at Birmingham
2010-2013
Dysregulated host responses to infection can lead organ dysfunction and sepsis, causing millions of global deaths each year. To alleviate this burden, improved prognostication biomarkers response are urgently needed. We investigated the use whole-blood transcriptomics for stratification patients with severe by integrating data from 3149 samples sepsis due community-acquired pneumonia or fecal peritonitis admitted intensive care healthy individuals into a gene expression reference map. used...
Sepsis, the dysregulated host response to infection causing life-threatening organ dysfunction, is a global health challenge requiring better understanding of pathophysiology and new therapeutic approaches. Here, we applied high-throughput tandem mass spectrometry delineate plasma proteome for sepsis comparator groups (noninfected critical illness, postoperative inflammation, healthy volunteers) involving 2612 samples (from 1611 patients) 4553 liquid chromatography–mass analyses acquired...
Objective The objective of this paper is to investigate the safety, pharmacokinetics (PK) and immunogenicity CDP7657, a PEGylated anti-CD40L antibody fragment, in healthy individuals patients with systemic lupus erythematosus (SLE). Methods This randomized, double-blind, single-dose, dose-escalation phase I study consisted two parts. In part 1, 28 received CDP7657 IV (0.004–5 mg/kg) or placebo. 2, 17 SLE (5–60 CDP7657:placebo ratio was 3:1. Results Adverse events (AEs) were reported by 76%...
Sepsis is a clinical syndrome of life-threatening organ dysfunction caused by dysregulated response to infection, for which disease heterogeneity major obstacle developing targeted treatments. We have previously identified gene-expression-based patient subgroups (sepsis signatures [SRS]) informative outcome and underlying pathophysiology. Here, we aimed investigate the role genetic variation in determining host transcriptomic delineate regulatory networks SRS. Using genotyping RNA-sequencing...
Cell culture models of oncogenesis that use cellular reprogramming to generate a neoplastic cell from normal provide one the few opportunities study early stages breast cancer development. Human mammary epithelial cells (HMECs) were induced undergo transformation using defined genetic elements transformed HMECs (THMECs). To identify proteins displayed significantly different levels abundance at three consecutive time points in over an 80 day period, protein extracts analyzed by...
Millions of newborns die annually from preventable causes, with the highest rates occurring in Africa. Reducing neonatal mortality requires investment to scale hospital care, which includes providing hospitals appropriate technology care for small and sick newborns. Expensive medical devices designed high-resource settings often fail withstand conditions low-resource hospitals, including humidity, dust, frequent user turnover, complex maintenance, lack stable power, or difficulty sourcing...
Aim: Neoplastic transformation provides one of the few existing opportunities to analyze molecular changes in real time during initiation and progression breast cancer. Materials & methods: Human mammary epithelial cells underwent neoplastic reprogramming, generating line semitransformed, premalignant two separate, temporal lines fully transformed human (THMECs). An Illumina Infinium HumanMethylation27 BeadChip was used DNA methylation alterations 27,578 CpG loci at three consecutive points...
Nephrotic syndrome can result in worsening of existing hypothyroidism patients requiring thyroid hormone supplementation. The urinary loss thyroxine-binding globulin, as well increased gut edema, likely lead to reduced absorption and retention exogenous hormone. Here, we present a case patient with Hashimoto's thyroiditis, previously well-controlled on levothyroxine, who developed symptomatic newly diagnosed nephrotic syndrome, whose symptoms improved transition an alternative formulation...
Drug-induced liver injury is a common cause of acute failure. β-blockers are widely prescribed class medications; however, hepatotoxicity rare adverse effect this medication which clinicians must be aware. This case suggests that may β-blockers.
CASE REPORT A 70-year-old man with a medical history of right hallux acrolentiginous melanoma, previously in remission for 6 months after adjuvant chemoradiotherapy, was referred evaluation new gastric and duodenal lesions seen on routine surveillance positron emission tomography scan. He presented several early satiety asymptomatic microcytic anemia. Small bowel enteroscopy demonstrated two 5-mm pigmented masses along the lesser curvature body superficial ulcerations, 3-cm ulcerated mass...
Background The Brain Biomarker after Trauma Cohort Study (BBATS) investigates potential biomarkers in traumatic brain injury, for guiding diagnosis, prognosis and treatment of injury. It has been running 19 months. Blood samples must be obtained within 60 minutes (i.e. the ‘Golden Hour’) National Institute Health Research (NIHR) Surgical Reconstruction Microbiology Centre (SRMRC) trauma research team recruit patients at scene This requires extensive collaboration with ambulance service order...