A5007249471- Immunotherapy and Immune Responses
- Toxoplasma gondii Research Studies
- Glycosylation and Glycoproteins Research
- Parasitic Infections and Diagnostics
- Animal Disease Management and Epidemiology
- Family and Patient Care in Intensive Care Units
- Immune Cell Function and Interaction
- Nosocomial Infections in ICU
- Monoclonal and Polyclonal Antibodies Research
- Drug Transport and Resistance Mechanisms
- Virus-based gene therapy research
- Advanced Optimization Algorithms Research
- Sepsis Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Dye analysis and toxicity
- Intensive Care Unit Cognitive Disorders
- Lipid Membrane Structure and Behavior
- Palliative Care and End-of-Life Issues
- Cancer Immunotherapy and Biomarkers
- Optimization and Variational Analysis
- CAR-T cell therapy research
- Animal Virus Infections Studies
- Respiratory Support and Mechanisms
- Vector-Borne Animal Diseases
- Immune cells in cancer
University of California, Santa Cruz
2024
Newcastle upon Tyne Hospitals NHS Foundation Trust
2015-2024
Freeman Hospital
2014-2024
Texas Tech University
2011-2024
Texas Tech University Health Sciences Center
2012-2024
Amarillo VA Health Care System
1999-2024
Vanderbilt University Medical Center
2023
Miami University
2007-2023
Carson Newman University
2009-2020
Veterans Health Administration
1993-2019
Proton pump inhibitors (PPIs) or histamine-2 receptor blockers (H2RBs) are often prescribed for patients as stress ulcer prophylaxis drugs in the intensive care unit (ICU). The comparative effect of these on mortality is unknown.To compare in-hospital rates using PPIs vs H2RBs prophylaxis.Cluster crossover randomized clinical trial conducted at 50 ICUs 5 countries between August 2016 and January 2019. Patients requiring invasive mechanical ventilation within 24 hours ICU admission were...
Background Early physical rehabilitation in the intensive care unit (ICU) has been shown to improve short-term clinical outcomes but long-term benefit not proven and optimum intensity of is known. Methods We conducted a randomised, parallel-group, allocation-concealed, assessor-blinded, controlled trial patients who had received at least 48 hours invasive or non-invasive ventilation. Participants were randomised 1:1 ratio, stratified by admitting ICU, admission type level independence. The...
BackgroundVentilator-associated pneumonia is the most common intensive care unit (ICU)-acquired infection, yet accurate diagnosis remains difficult, leading to overuse of antibiotics. Low concentrations IL-1β and IL-8 in bronchoalveolar lavage fluid have been validated as effective markers for exclusion ventilator-associated pneumonia. The VAPrapid2 trial aimed determine whether measurement could effectively safely improve antibiotic stewardship patients with clinically suspected...
We injected chick syncytial strain of reticuloendotheliosis virus (CS-REV) and wild type recombinant avian leukosis (ALV) near the blastoderm unincubated fertilized embryos CS-REV intra-abdominally at day hatch, we progeny tested surviving ALV viremic males REV females for transmitted viral genetic material. A number positive were identified their deoxyribonucleic acid (DNA) analyzed restriction enzyme fragments that hybridized with Most had simple patterns unlike parents or congenitally...
<h3>Background</h3> Excessive use of empirical antibiotics is common in critically ill patients. Rapid biomarker-based exclusion infection may improve antibiotic stewardship ventilator-acquired pneumonia (VAP). However, successful validation the usefulness potential markers this setting exceptionally rare. <h3>Objectives</h3> We sought to validate capacity for specific host inflammatory mediators exclude patients with suspected VAP. <h3>Methods</h3> A prospective, multicentre, study VAP was...
Background Critically ill patients with impaired neutrophil phagocytosis have significantly increased risk of nosocomial infection. Granulocyte-macrophage colony-stimulating factor (GM-CSF) improves by neutrophils ex vivo. This study tested the hypothesis that GM-CSF in critically whom is known to be impaired. Methods was a multicentre, phase IIa randomised, placebo-controlled clinical trial. Using personalised medicine approach, only were included. Patients randomised 1:1 subcutaneous (3...
Distortion parameters [� , � 2 DI(Y‐O), DI(O‐ Y‐O), DI(O‐O)] have been calculated for cation polyhedra in tourmalines of different chemical compositions. Tourmalines with greater amounts small, highly charged ions the YO6 octahedron display bond-length distortion Y. The size and charge occupants at Y site included an empirically determined formula intended to evaluate octahedron. This equation demonstrates that is a function Y-site occupants, predictable from those (r = 0.972 observed versus...
Objectives: Transfusion-related acute lung injury may contribute to the development of in critically ill, due plasma from female donors containing antileukocyte antibodies. In July 2003, U.K. National Blood Service stopped using donor for production fresh frozen plasma. Patients undergoing repair a ruptured abdominal aortic aneurysm receive large amounts and often develop injury. We investigated whether change male was associated with frequency these patients. Design: A retrospective, before...
Stocks of cloned helper-independent Rous sarcoma virus (RSV) spontaneously segregate transformation-defective (td) mutants that appear to have an RNA genome composed smaller subunits than those the patent virus. Differential hybridization and competitive techniques involving reactions between viral proviral sequences in host cell DNA (under conditions initial excess) were used measure extent deletion a td mutant Prague strain (Pr) RSV (Pr RSV-C). Viral 60 70S labeled 1 5 x 10(7) counts per...