A5001917936- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Bacterial biofilms and quorum sensing
- Vibrio bacteria research studies
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Use and Resistance
- Antimicrobial Resistance in Staphylococcus
- Infections and bacterial resistance
- Bacterial Identification and Susceptibility Testing
- Tuberculosis Research and Epidemiology
- Bacteriophages and microbial interactions
- Enterobacteriaceae and Cronobacter Research
- Escherichia coli research studies
- Salmonella and Campylobacter epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Bacterial Genetics and Biotechnology
- Mycobacterium research and diagnosis
- Mathematical Dynamics and Fractals
- Antimicrobial Peptides and Activities
- Aquaculture disease management and microbiota
- Streptococcal Infections and Treatments
- Algorithms and Data Compression
- Urinary Tract Infections Management
- Microbial Metabolism and Applications
University of Oxford
2020-2025
Ineos (United Kingdom)
2021-2025
Cardiff University
2015-2024
China Agricultural University
2017-2024
New York Psychoanalytic Society and Institute
2024
New York State Psychiatric Institute
2024
Columbia University Irving Medical Center
2024
Emory University
2024
Institute for Health Metrics and Evaluation
2023
University of Washington
2023
BackgroundGram-negative Enterobacteriaceae with resistance to carbapenem conferred by New Delhi metallo-β-lactamase 1 (NDM-1) are potentially a major global health problem. We investigated the prevalence of NDM-1, in multidrug-resistant India, Pakistan, and UK.MethodsEnterobacteriaceae isolates were studied from two centres India—Chennai (south India), Haryana (north India)—and those referred UK's national reference laboratory. Antibiotic susceptibilities assessed, presence gene blaNDM-1 was...
A Swedish patient of Indian origin traveled to New Delhi, India, and acquired a urinary tract infection caused by carbapenem-resistant Klebsiella pneumoniae strain that typed the sequence type 14 complex. The isolate, 05-506, was shown possess metallo-beta-lactamase (MBL) but negative for previously known MBL genes. Gene libraries amplification class 1 integrons revealed three resistance-conferring regions; first contained bla(CMY-4) flanked ISEcP1 blc. second region 4.8 kb complex integron...
Understanding of the factors driving global antimicrobial resistance is limited. We analysed and antibiotic consumption worldwide versus many potential contributing factors.Using three sources data (ResistanceMap, WHO 2014 report on resistance, contemporary publications), we created two indices for 103 countries using from 2008 to 2014: Escherichia coli resistance-the average prevalence E bacteria that were resistant third-generation cephalosporins fluoroquinolones, aggregate combined...
Escherichia coli sequence type 131 (ST131) is a globally disseminated, multidrug resistant (MDR) clone responsible for high proportion of urinary tract and bloodstream infections. The rapid emergence successful spread E. ST131 strongly associated with several factors, including resistance to fluoroquinolones, virulence gene content, the possession 1 fimbriae FimH30 allele, production CTX-M-15 extended spectrum β-lactamase (ESBL). Here, we used genome sequencing examine molecular epidemiology...
The mobile colistin resistance gene mcr-1 has attracted global attention, as it heralds the breach of polymyxins, one last-resort antibiotics for treatment severe clinical infections caused by multidrug-resistant Gram-negative bacteria. To date, six slightly different variants mcr-1, and a second gene, mcr-2, have been reported or annotated in GenBank database. Here, we characterized third mcr-3 coexisted with 18 additional determinants 261-kb IncHI2-type plasmid pWJ1 from porcine...
The NDM-1 gene, first identified in Sweden 2008 Klebsiella pneumoniae from a patient hospitalized New Delhi, encodes metallo-β-lactamase that inactivates all β-lactams except aztreonam. This blaNDM-1 gene has been hospital-acquired bacterial species, such as K. pneumoniae, but also the typical community-acquired Escherichia coli. strains possess other resistance mechanisms contributing to their multidrug patterns. It recently extensively reported UK, India and Pakistan and, albeit lesser...
Antimicrobial resistance in neonatal sepsis is rising, yet mechanisms of that often spread between species via mobile genetic elements, ultimately limiting treatments low- and middle-income countries (LMICs), are poorly characterized. The Burden Antibiotic Resistance Neonates from Developing Societies (BARNARDS) network was initiated to characterize the cause burden antimicrobial for seven LMICs Africa South Asia. A total 36,285 neonates were enrolled BARNARDS study November 2015 December...