A5091525985- Neonatal and Maternal Infections
- Antibiotic Resistance in Bacteria
- Leprosy Research and Treatment
- Vibrio bacteria research studies
- Bacterial biofilms and quorum sensing
- Bacterial Identification and Susceptibility Testing
- Global Maternal and Child Health
- Sepsis Diagnosis and Treatment
- Urinary Tract Infections Management
- Antibiotic Use and Resistance
- Diabetic Foot Ulcer Assessment and Management
- Nail Diseases and Treatments
- Immune cells in cancer
- Enterobacteriaceae and Cronobacter Research
- Breastfeeding Practices and Influences
- Streptococcal Infections and Treatments
- Infant Nutrition and Health
- Herpesvirus Infections and Treatments
- Oral Health Pathology and Treatment
- Wound Healing and Treatments
- Immune Cell Function and Interaction
- Nosocomial Infections in ICU
- Vascular Malformations Diagnosis and Treatment
- Maternal and fetal healthcare
- Antibiotics Pharmacokinetics and Efficacy
St. Paul's Hospital Millennium Medical College
2018-2024
Ben-Gurion University of the Negev
2015-2017
Schieffelin Institute of Health Research and Leprosy Centre
1996-2001
Yeshiva University
1960
Antimicrobial resistance in neonatal sepsis is rising, yet mechanisms of that often spread between species via mobile genetic elements, ultimately limiting treatments low- and middle-income countries (LMICs), are poorly characterized. The Burden Antibiotic Resistance Neonates from Developing Societies (BARNARDS) network was initiated to characterize the cause burden antimicrobial for seven LMICs Africa South Asia. A total 36,285 neonates were enrolled BARNARDS study November 2015 December...
BackgroundNeonatal sepsis is a primary cause of neonatal mortality and an urgent global health concern, especially within low-income middle-income countries (LMICs), where 99% occurs. The aims this study were to determine the incidence associations with all-cause in facility-born neonates LMICs.MethodsThe Burden Antibiotic Resistance Neonates from Developing Societies (BARNARDS) recruited mothers their into prospective observational cohort across 12 clinical sites Bangladesh, Ethiopia,...
Abstract Hospital surfaces can harbour bacterial pathogens, which may disseminate and cause nosocomial infections, contributing towards mortality in low- middle-income countries (LMICs). During the BARNARDS study, hospital from neonatal wards were sampled to assess degree of environmental surface patient care equipment colonisation by Gram-negative bacteria (GNB) carrying antibiotic resistance genes (ARGs). Here, we perform PCR screening for extended-spectrum β-lactamases ( bla CTX-M-15 )...
Sepsis is a major contributor to neonatal mortality, particularly in low-income and middle-income countries (LMICs). WHO advocates ampicillin-gentamicin as first-line therapy for the management of sepsis. In BARNARDS observational cohort study sepsis antimicrobial resistance LMICs, common pathogens were characterised via whole genome sequencing (WGS) profiles. this substudy BARNARDS, we aimed assess use efficacy empirical antibiotic therapies commonly used LMICs
Abstract Early development of the microbiome has been shown to affect general health and physical infant and, although some studies have undertaken in high-income countries, there are few from low- middle-income countries. As part BARNARDS study, we examined rectal microbiota 2,931 neonates (term used up 60 d) with clinical signs sepsis 15,217 mothers screening for bla CTX-M-15 , NDM KPC OXA-48 -like genes, which were detected 56.1%, 18.5%, 0% 4.1% neonates’ swabs 47.1%, 4.6%, 1.6% mothers’...
Newborn sepsis accounts for more than a third of neonatal deaths globally and one in five Ethiopia. The first-line treatment recommended by WHO is the combination gentamicin with ampicillin or benzylpenicillin. Gram-negative bacteria (GNB) are increasingly resistant to previously effective antibiotics.
Arteriovenous aneurysm of the vein Galen is a rare malformation. This paper presents pathologic and clinical features an additional case. These findings are compared with data previous cases in literature. <h3>Report Case</h3> white male infant was 6 weeks old when he admitted to Montefiore Hospital on March 2, 1959. The mother's pregnancy, labor, delivery had been normal. child weighed 8 lb. 10 oz. (3,910 gm.) at birth but persistently cyanotic. In second week life episode dyspnea tachypnea...
In low- and middle-income countries (LMIC) Staphylococcus aureus is regarded as one of the leading bacterial causes neonatal sepsis, however there limited knowledge on species diversity antimicrobial resistance caused by Gram-positive bacteria (GPB).We characterised GPB isolates from blood cultures LMICs in Africa (Ethiopia, Nigeria, Rwanda, South Africa) South-Asia (Bangladesh Pakistan) between 2015-2017. We determined minimum inhibitory concentrations performed whole genome sequencing...
Background: Neonatal sepsis is the third leading cause of neonatal mortality, behind prematurity and intrapartum-related complications. The main objectives this study are to assess proportion in preterm newborns identify etiologic agents their antibiotic sensitivity patterns. Methods: A longitudinal observational was done from July 2016 May 2018. Whenever clinical diagnosis made, blood cultures susceptibility tests were done. Result: We did 690 cultures, 255 (36.9%) showing bacterial growth....
Purpose: The Enterobacterales family colonizes the human gut as normal flora in all age groups, with bacterial infections being most common cause. Resistance is currently observed flora. aim of this study was to determine frequency fecal carriage carbapenem-resistant (CRE), carbapenemase-producing (CPE), and associated factors faeces admitted patients. Methods: A cross-sectional conducted Saint Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia. total 384 rectal swabs were...
The natural killer (NK) cell activating receptor NKp46/NCR1 plays a critical role in elimination of virus-infected and tumor cells. NCR1 gene can be transcribed into five different splice variants, but the functional importance physiological distribution NKp46 isoforms are not yet fully understood. Here, we shed light on differential expression variants viral respiratory tract infections their difference at cellular level. was most predominantly expressed cytotoxicity nasal lavage patients...
Background . Diagnosis using reliable tools and treatment following in vitro antimicrobial susceptibility tests are critical to proper addressing of antibiotic-resistant Salmonella infection. Methodology A cross-sectional study was conducted assess the practice diagnosis salmonellosis Addis Ababa. Tube Widal test (for blood samples only), culture, biochemical carbohydrate fermentation, serotyping, were employed for both stool samples. Results Of all diseases listed diagnosis, nontyphoidal...
<h3>Introduction</h3> In the literature of first three decades this century, central origin periodic paralysis was postulated. As it became clear that associated with hypopotassemia, possible role nervous system in condition summarily discounted. That hypopotassemia<i>in itself</i>is not basic factor is supported by following facts. Cases familial have been reported without alteration serum potassium during an attack.<sup>1-5</sup>(Some these cases, for example Wolf's,<sup>1</sup>may...
This retrospective study of 52 patients, who underwent joint stabilization procedures for static deformities the feet in leprosy between 1971 and 1985, was undertaken to asses long-term results fixed leprosy. The main purpose is make plantigrade weight bearing wearing footwear possible. Deformities corrected include varus, equinus equinovarus. Chronic ulceration occurs repeatedly if these are not leads inevitable bone destruction eventual amputation.
Providing adequate nutrition to preterm infants who are born HIV-positive mothers is more challenging due the mother's underlying health and status. The understanding of these issues active participation have a significant role in giving continuous care for HIV-exposed infant. Hence, this study aimed explore experience mothers' feeding practice their infants, workers identify barriers facilitators infants.A phenomenological qualitative design was conducted Addis Ababa, Ethiopia, between May...
Abstract Inanimate surfaces in hospital settings can harbour bacterial pathogens, which disseminate and cause nosocomial infections, resulting unacceptable mortality low- middle-income countries (LMICs). As part of the BARNARDS study, this swabs study determined were colonised by Gram-negative bacteria (GNB) carrying antibiotic resistance genes (ARGs). PCR screening for presence extended-spectrum β-lactamases ( bla CTX-M-15 ) carbapenemases NDM , OXA-48 -like KPC showed higher prevalence...
Pregnancy can pose a risk to women on tuberculosis (TB) treatment with threat the wellbeing of mother and fetus. Physiological stress-related effects result when pregnancy occurs during TB illness while treatment. Hence, this study aimed assess contraceptive utilization, unmet need among treatment, integration family planning (FP) services clinics in Addis Ababa, Ethiopia.
Abstract Introduction: Pregnancy can pose a risk to women on tuberculosis (TB) treatment with threat the mother, fetus, and family at large. Contraceptive counseling provision should be an integral part of TB clinics. Physiological stress-related effects result when pregnancy occurs illness while treatment. Hence, this study aimed assess contraceptive utilization, unmet need among treatment, integration planning (FP) services clinics in Addis Ababa, Ethiopia. Methods: A facility-based...