A5016866135- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Bacterial biofilms and quorum sensing
- Clostridium difficile and Clostridium perfringens research
- Archaeology and Natural History
- Infective Endocarditis Diagnosis and Management
- Archaeology and ancient environmental studies
- Streptococcal Infections and Treatments
- Poetry Analysis and Criticism
- Neonatal and Maternal Infections
- Cardiac Valve Diseases and Treatments
- Transplantation: Methods and Outcomes
- Renaissance Literature and Culture
- Antifungal resistance and susceptibility
- Irish and British Studies
- Libraries, Manuscripts, and Books
- Shakespeare, Adaptation, and Literary Criticism
- Dermatology and Skin Diseases
- Classical Antiquity Studies
- Medieval Iberian Studies
- Antibiotic Resistance in Bacteria
- Vasculitis and related conditions
- Cell Adhesion Molecules Research
- Infectious Aortic and Vascular Conditions
- Food Safety and Hygiene
Cardiff University
2022-2024
Washington University in St. Louis
2014-2023
Ranken Jordan Pediatric Bridge Hospital
2023
University of New Mexico
2010-2018
Society of American Foresters
2015
Queensland Health
2007-2014
Royal Brisbane and Women's Hospital
2011-2013
Princess Alexandra Hospital
1989-2013
Columbus State University
2011
Hy-Line (United States)
2003
Abstract Hospital surfaces can harbour bacterial pathogens, which may disseminate and cause nosocomial infections, contributing towards mortality in low- middle-income countries (LMICs). During the BARNARDS study, hospital from neonatal wards were sampled to assess degree of environmental surface patient care equipment colonisation by Gram-negative bacteria (GNB) carrying antibiotic resistance genes (ARGs). Here, we perform PCR screening for extended-spectrum β-lactamases ( bla CTX-M-15 )...
Decolonization measures, including mupirocin and chlorhexidine, are often prescribed to prevent Staphylococcus aureus skin soft tissue infections (SSTI). The objective of this study was determine the prevalence high-level chlorhexidine resistance in S. strains recovered from patients with SSTI before after administration whether carriage a mupirocin- or chlorhexidine-resistant strain at baseline precluded eradication. We recruited 1,089 community-onset without colonization. In addition...
Background. Community-associated Staphylococcus aureus infections often affect multiple members of a household. We compared 2 approaches to S. eradication: decolonizing the entire household versus index case alone.
Staphylococcus aureus is among the leading causes of human infection. Widespread drug resistance, emergence highly virulent strains, and ability S. to colonize >30% population contribute this organism's pathogenic success. Human serologic responses their relationship protective immunity remain incompletely defined, challenging strategic development efficacious vaccines.We measured humoral 2 staphylococcal exotoxins, α-hemolysin (Hla) Panton-Valentine leukocidin (PVL; LukF-PV/LukS-PV...
Abstract Early development of the microbiome has been shown to affect general health and physical infant and, although some studies have undertaken in high-income countries, there are few from low- middle-income countries. As part BARNARDS study, we examined rectal microbiota 2,931 neonates (term used up 60 d) with clinical signs sepsis 15,217 mothers screening for bla CTX-M-15 , NDM KPC OXA-48 -like genes, which were detected 56.1%, 18.5%, 0% 4.1% neonates’ swabs 47.1%, 4.6%, 1.6% mothers’...
<h3>Background</h3> Myasthenia gravis is an autoimmune disorder of the neuromuscular junction. Rituximab (RTX), a monoclonal antibody to CD20, leads B lymphocyte depletion and has been used in some disorders, including small case series myasthenia patients. <h3>Methods</h3> A retrospective analysis was performed all patients with acetylcholine receptor (AChR) (11 subjects) or muscle specific kinase (MuSK) positive (three subjects), who had treated RTX Brisbane, Australia. In most 1 g RTX,...
Background. Live attenuated varicella vaccine is considered a safe with serious adverse effects reported only in immunocompromised children. We describe severe life-threatening infection virus causing rash and pneumonitis 6-year-old boy no apparent immunodeficiency.
<h3>Objectives</h3>To measure prevalence of Staphylococcus aureus colonization in household contacts children with acute S skin and soft tissue infections (SSTI), determine risk factors for contacts, assess anatomic sites patients contacts.<h3>Design</h3>Cross-sectional study.<h3>Setting</h3>St Louis Children's Hospital Emergency Department ambulatory wound center 9 community pediatric practices affiliated a practice-based research network.<h3>Participants</h3>Patients community-associated...
Household environmental surfaces may serve as vectors for the acquisition and spread of methicillin-resistant Staphylococcus aureus (MRSA) among household members, although few studies have evaluated which objects are important reservoirs MRSA.To determine prevalence MRSA contamination in households children with infection; define molecular epidemiology environmental, pet, human strains within households; identify factors associated contamination.Fifty active or recent culture-positive...
We examined food consumption patterns of U.S. students temporarily living in Guadalajara, Mexico. Consumption foods prepared Mexican homes was associated with an increased risk acquisition diarrhea. Foods from commercial sources and private Guadalajara were subsequently for contamination coliforms, fecal bacterial enteropathogens. For comparison, selected restaurant obtained Houston, Tex. Food showed generally higher counts coliforms than those Mexico Houston. The Mexico, both sources,...
Historically, a number of typing methods have been evaluated for Staphylococcus aureus strain characterization. The emergence contemporary strains community-associated S. aureus, and the ensuing epidemic with predominant type (USA300), necessitates re-evaluation discriminatory power these discerning molecular epidemiology transmission dynamics, essential to investigations hospital community outbreaks. We compared index 5 Children presenting St. Louis Children's Hospital pediatric practices...
Staphylococcus aureus colonization poses risk for subsequent skin and soft tissue infection (SSTI). We hypothesized that including systemic antibiotics in the management of S. SSTI, conjunction with incision drainage, would reduce incidence recurrent infection.We prospectively evaluated 383 children SSTI requiring drainage anterior nares, axillae, or inguinal folds at baseline screening. Systemic antibiotic prescribing point care was recorded. Repeat sampling performed within 3 months...
<h3>Importance</h3> The longitudinal association among persistent<i>Staphylococcus aureus</i>colonization, household environmental contamination, and recurrent skin soft tissue infection (SSTI) is largely unexplored to date. <h3>Objectives</h3> To identify factors associated with persistent<i>S aureus</i>colonization SSTI in households children community-associated methicillin-resistant<i>S aureus</i>(MRSA) SSTI. <h3>Design, Setting, Participants</h3> This 12-month prospective cohort study...
Select methicillin-susceptible Staphylococcus aureus (MSSA) strains may produce β-lactamases with affinity for first-generation cephalosporins (1GCs). In the setting of a high inoculum, these promote cleavage 1GCs, phenomenon known as cefazolin inoculum effect (CzIE). We evaluated prevalence and impact CzIE on clinical outcomes among MSSA acute hematogenous osteomyelitis (AHO) cases. AHO isolates obtained from two children’s hospitals between January 2011 December 2018 were procured through...
Objective: To study the humoral immune responses, safety, and tolerability of intradermal recombinant hepatitis B vaccination in healthcare workers (HCWs) nonresponsive to previous repeated intramuscular vaccination. Design: An open, prospective, before–after trial. Setting: A tertiary referral hospital surrounding district health service Queensland, Australia. Participants: Hospital community HCWs Methods: Intradermal vaccine was administered every second week for a maximum 4 doses....