A5054723539- Neonatal and Maternal Infections
- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Global Maternal and Child Health
- Urinary Tract Infections Management
- Infant Nutrition and Health
- Infection Control in Healthcare
- Tuberculosis Research and Epidemiology
- Nosocomial Infections in ICU
- Diagnosis and treatment of tuberculosis
- Pneumonia and Respiratory Infections
- Vaccine Coverage and Hesitancy
- Bacterial Identification and Susceptibility Testing
- Infant Development and Preterm Care
- Parasites and Host Interactions
- Pneumocystis jirovecii pneumonia detection and treatment
- Mycobacterium research and diagnosis
- Sepsis Diagnosis and Treatment
- Hepatitis C virus research
- HIV/AIDS Research and Interventions
- Gut microbiota and health
- HIV-related health complications and treatments
- Vibrio bacteria research studies
- Delphi Technique in Research
- Bacterial biofilms and quorum sensing
Africa Centres for Disease Control and Prevention
2024
Stellenbosch University
2016-2023
Infection Control Africa Network
2016-2023
Université Catholique de Bukavu
2009-2023
Western Cape Department of Health
2017-2021
Tygerberg Hospital
2016-2019
International Society for Infectious Diseases
2019
International Center for Advanced Research and Training
2017
University of Kinshasa
2016
The October 2020 Global TB report reviews control strategies and United Nations (UN) targets set in the political declaration at September 2018 UN General Assembly high-level meeting on held New York. Progress care prevention has been very slow. In 2019, remained most common cause of death from a single infectious pathogen. Globally, an estimated 10.0 million people developed disease there were 1.2 deaths among HIV-negative additional 208, 000 living with HIV. Adults accounted for 88%...
Antimicrobial resistance in neonatal sepsis is rising, yet mechanisms of that often spread between species via mobile genetic elements, ultimately limiting treatments low- and middle-income countries (LMICs), are poorly characterized. The Burden Antibiotic Resistance Neonates from Developing Societies (BARNARDS) network was initiated to characterize the cause burden antimicrobial for seven LMICs Africa South Asia. A total 36,285 neonates were enrolled BARNARDS study November 2015 December...
BackgroundNeonatal sepsis is a primary cause of neonatal mortality and an urgent global health concern, especially within low-income middle-income countries (LMICs), where 99% occurs. The aims this study were to determine the incidence associations with all-cause in facility-born neonates LMICs.MethodsThe Burden Antibiotic Resistance Neonates from Developing Societies (BARNARDS) recruited mothers their into prospective observational cohort across 12 clinical sites Bangladesh, Ethiopia,...
Sepsis is a major contributor to neonatal mortality, particularly in low-income and middle-income countries (LMICs). WHO advocates ampicillin-gentamicin as first-line therapy for the management of sepsis. In BARNARDS observational cohort study sepsis antimicrobial resistance LMICs, common pathogens were characterised via whole genome sequencing (WGS) profiles. this substudy BARNARDS, we aimed assess use efficacy empirical antibiotic therapies commonly used LMICs
Abstract Early development of the microbiome has been shown to affect general health and physical infant and, although some studies have undertaken in high-income countries, there are few from low- middle-income countries. As part BARNARDS study, we examined rectal microbiota 2,931 neonates (term used up 60 d) with clinical signs sepsis 15,217 mothers screening for bla CTX-M-15 , NDM KPC OXA-48 -like genes, which were detected 56.1%, 18.5%, 0% 4.1% neonates’ swabs 47.1%, 4.6%, 1.6% mothers’...
Background: Necrotizing enterocolitis (NEC) is a multifactorial disease, causing inflammation of the bowel. The exact root NEC still unknown, but low weight and gestational age at birth are known causes. Furthermore, antibiotic use abnormal bacterial colonization premature gut possible Premature neonates often experience feeding intolerances that disrupts nutritional intake, leading to poor growth neurodevelopmental impairment. Methods: We conducted double-blind, placebo-controlled,...
In low- and middle-income countries (LMIC) Staphylococcus aureus is regarded as one of the leading bacterial causes neonatal sepsis, however there limited knowledge on species diversity antimicrobial resistance caused by Gram-positive bacteria (GPB).We characterised GPB isolates from blood cultures LMICs in Africa (Ethiopia, Nigeria, Rwanda, South Africa) South-Asia (Bangladesh Pakistan) between 2015-2017. We determined minimum inhibitory concentrations performed whole genome sequencing...
During the recent Ebola outbreak, spraying of environment and humans, including healthcare workers, with chlorine was wide spread in affected African countries; adverse clinical effects are reported here. A cross sectional survey by interview 1550 volunteers consisting 500 workers (HCW), 550 survivors (EVD) quarantined asymptomatic contacts (NEVD) conducted. Demographics, frequency exposure to chlorine, condition after particularly eye, respiratory skin conditions were noted. The length time...
Abstract Background Multidrug-resistant tuberculosis (MDR-TB) jeopardizes global TB control. The prevalence and predictors of Rifampicin-resistant (RR) TB, a proxy for MDR-TB, the treatment outcomes with standard shortened regimens have not been assessed in post-conflict regions, such as South Kivu province eastern Democratic Republic Congo (DRC). We aimed to fill this knowledge gap inform DRC National Program. Methods adults children evaluated pulmonary by sputum smear microscopy Xpert...
BackgroundEpidemiological data on neonatal bloodstream infections (BSI) in sub-Saharan Africa are extremely limited.MethodsA comparative analysis of laboratory-confirmed BSI episodes was conducted retrospectively two large units Botswana and South (January 1 to December 31, 2017). Routine laboratory ward register were used determine rates, the pathogen spectrum, outcomes.ResultsIn 2017, Princess Marina Hospital (PMH) Tygerberg (TBH) admitted 1187 2826 neonates, respectively. The incidence...
Abstract Background Rifampicin (RIF) resistance is highly correlated with isoniazid (INH) and used as proxy for multidrug-resistant tuberculosis (MDR-TB). Using MTBDRplus a comparator, we evaluated the predictive value of Xpert MTB/RIF (Xpert)–detected RIF MDR-TB in eastern Democratic Republic Congo (DRC). Methods We conducted cross-sectional study involving data from new or retreatment pulmonary adult TB cases between July 2013 December 2016. Separate, paired sputa smear microscopy were...
To determine the prevalence of and risk factors for metabolic syndrome (MS) in HIV-infected adults at three urban clinics Bukavu, Democratic Republic Congo.Cross-sectional study.From July to September 2016, baseline socio-demographics, clinical characteristics were collected using a structured questionnaire or extracted from medical records. Fasting blood sugar lipids measured. MS was defined per National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III) International...
Abstract Objectives To establish the knowledge, attitudes and practices (KAP) regarding antibiotic use self-medication among pregnant women. Methods We conducted a KAP survey of 301 women hospitalized at tertiary hospital obstetric service in Cape Town, South Africa November December 2017, using an interviewer-administered 12 item questionnaire. stratified analysis by participants’ mean knowledge score (K-score) group (<6 versus ≥6 out 7 questions). Multivariate models were built to...
The aim of this study was to determine the incidence rates HIV1/2 antibodies, HBV and HCV antibodies among voluntary blood donors estimate residual risk HIV, infection in Bukavu. We conducted a follow-up cohort volunteer who have made at least two donations Bukavu (DRC) between January 2010 December 2012. recorded 2986 during period. viral transmission associated with serological window considered as equals rate multiplied by duration period divided 365. Seroprevalence 1.1% for HIV 1/2 4.0%...
To assess the current involvement of nurses in use and management antimicrobials their training antimicrobial stewardship (AMS) across Africa. After a pilot study, an online questionnaire (SurveyMonkey) both French English was circulated via Infection Control Africa Network (ICAN) mailing list to members non-members The study conducted from 26 May 19 August 2016. Data were summarized proportions bar charts; compared using χ2 test. A multivariate logistic regression model built identify...
Abstract Objective To determine the prevalence and factors associated with optimal antiretroviral therapy ( ART ) adherence virological failure VLF among HIV ‐infected adults enrolled in national programme at teaching hospital of Fann, Dakar, Senegal. Methods Cross‐sectional study from 1 September 2013 to 30 January 2014. Outcomes: (1) by Center for Adherence Support Evaluation CASE Index Score (>10) (2) (HIV RNA > 1000 copies/ml). Diagnostic accuracy assessed using sensitivity (Se),...
Background: The main nutritional goal for premature neonates is to achieve a postnatal growth rate that the neonate would have experienced in utero. Postnatal failure is, however, very common and extremely low birth weight neonates. use of probiotics shows promising results reducing time full feeds, as well increased gain. optimal probiotic strain has, not been elucidated. aim present study was evaluate difference reach feeds between two treatment arms, using LabinicTM multi-strain placebo....
Mansonella perstans is a human filarial parasite transmitted by biting midges (Diptera: Ceratopogonidae) belonging to the genus Culicoides and it widely spread in sub-Saharan Africa. While most cases are asymptomatic, mansonelliasis can be associated with angioedema, arthralgia, swellings, pain scrotum or serous cavities such as pleura, peritoneum, pericardium, etc. Mansonelliasis really hard treat, but has been shown that an intensive treatment using albendazole clear parasite.Here we...