Sayoki Mfinanga

ORCID: 0000-0001-9067-2684
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About
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Research Areas
  • Tuberculosis Research and Epidemiology
  • Mycobacterium research and diagnosis
  • Pneumocystis jirovecii pneumonia detection and treatment
  • HIV/AIDS Research and Interventions
  • Diagnosis and treatment of tuberculosis
  • HIV/AIDS Impact and Responses
  • Pneumonia and Respiratory Infections
  • Global Public Health Policies and Epidemiology
  • Global Maternal and Child Health
  • Fungal Infections and Studies
  • Antifungal resistance and susceptibility
  • Viral Infections and Outbreaks Research
  • HIV-related health complications and treatments
  • Vaccine Coverage and Hesitancy
  • Infectious Diseases and Tuberculosis
  • Adolescent Sexual and Reproductive Health
  • Child Nutrition and Water Access
  • Poverty, Education, and Child Welfare
  • Chronic Disease Management Strategies
  • Healthcare Systems and Reforms
  • Mosquito-borne diseases and control
  • Nail Diseases and Treatments
  • Viral Infections and Vectors
  • HIV Research and Treatment
  • Health Systems, Economic Evaluations, Quality of Life

National Institute for Medical Research
2016-2025

Kampala International University
2024-2025

Liverpool School of Tropical Medicine
2018-2025

Muhimbili University of Health and Allied Sciences
2019-2025

University College London
2023-2025

Africa Academy for Public Health
2023-2024

Nelson Mandela African Institution of Science and Technology
2020-2023

King's College London
2023

Uganda Virus Research Institute
2021

Muhimbili National Hospital
2011-2021

The October 2020 Global TB report reviews control strategies and United Nations (UN) targets set in the political declaration at September 2018 UN General Assembly high-level meeting on held New York. Progress care prevention has been very slow. In 2019, remained most common cause of death from a single infectious pathogen. Globally, an estimated 10.0 million people developed disease there were 1.2 deaths among HIV-negative additional 208, 000 living with HIV. Adults accounted for 88%...

10.1016/j.ijid.2021.02.107 article EN cc-by-nc-nd International Journal of Infectious Diseases 2021-03-12

Background Cardiovascular disease (CVD) is the leading cause of adult mortality in low-income countries but data on prevalence cardiovascular risk factors such as hypertension are scarce, especially sub-Saharan Africa (SSA). This study aims to assess and determinants blood pressure four SSA populations rural Nigeria Kenya, urban Namibia Tanzania. Methods Findings We performed cross-sectional household surveys Kwara State, Nigeria; Nandi district, Kenya; Dar es Salaam, Tanzania Greater...

10.1371/journal.pone.0032638 article EN cc-by PLoS ONE 2012-03-12

Cryptococcal meningitis accounts for more than 100,000 human immunodeficiency virus (HIV)-related deaths per year. We tested two treatment strategies that could be sustainable in Africa the standard of 2 weeks amphotericin B plus flucytosine and effective widely used fluconazole monotherapy.We randomly assigned HIV-infected adults with cryptococcal to receive an oral regimen (fluconazole [1200 mg day] [100 kilogram body weight weeks), 1 week (1 day), or day). Each patient was also as a...

10.1056/nejmoa1710922 article EN New England Journal of Medicine 2018-03-14

The amount of CD4 T cells is used for monitoring HIV progression and improvement, to make decisions start antiretroviral therapy prophylactic drugs opportunistic infections. aim this study was determine normal reference values cells, lymphocytes, leucocytes haemoglobin level in healthy, negative adolescents adults rural northern Tanzania. A cross sectional conducted from September 2006 March 2007 Participants were recruited voluntary counselling testing clinics. Patients counselled test...

10.1186/1471-2334-9-1 article EN cc-by BMC Infectious Diseases 2009-01-13

BACKGROUND. Cryptococcal meningitis (CM) causes an estimated 180,000 deaths annually, predominantly in sub-Saharan Africa, where most patients receive fluconazole (FLC) monotherapy. While relapse after FLC monotherapy with resistant strains is frequently observed, the mechanisms and impact of emergence resistance human CM are poorly understood. Heteroresistance (HetR) — a subpopulation within susceptible strain recently described phenomenon Cryptococcus neoformans (Cn) gattii (Cg),...

10.1172/jci124516 article EN cc-by Journal of Clinical Investigation 2019-01-27

The appearance of novel pathogens humans with epidemic potential and high mortality rates have threatened global health security for centuries. Over the past few decades new zoonotic infectious diseases caused by arising from animal reservoirs included West Nile virus, Yellow fever Ebola Nipah Lassa Fever Hanta Dengue Rift Valley Crimean-Congo haemorrhagic severe acute respiratory syndrome coronavirus, highly pathogenic avian influenza viruses, Middle East Respiratory Syndrome Coronavirus,...

10.1016/j.ijid.2016.06.012 article EN cc-by-nc-nd International Journal of Infectious Diseases 2016-06-01

In a World Report about COVID-19 vaccine use in Tanzania,1Makoni M Tanzania refuses vaccines.Lancet. 2021; 397: 566Summary Full Text PDF PubMed Scopus (27) Google Scholar local context was not sufficiently considered to fully understand the country's position on pandemic and its of vaccines. We maintain that late President John Magufuli understood severity pandemic, which merits joint coordinated global efforts. early months between February April, 2020, Tanzanian Government quickly...

10.1016/s0140-6736(21)00678-4 article EN other-oa The Lancet 2021-04-01

The unprecedented and ongoing COVID-19 pandemic has exposed weaknesses in African countries' health systems. impact of shifted focus on for the past 2 years routine services, especially those epidemics Tuberculosis, HIV/AIDS Malaria, have been dramatic both quantity quality.

10.1016/j.ijid.2022.03.033 article EN cc-by-nc-nd International Journal of Infectious Diseases 2022-03-25

BackgroundIn sub-Saharan Africa, health-care provision for chronic conditions is fragmented. The aim of this study was to determine whether integrated management HIV, diabetes, and hypertension led improved rates retention in care people with diabetes or without adversely affecting HIV viral suppression among when compared standard vertical medium large health facilities Uganda Tanzania.MethodsIn INTE-AFRICA, a pragmatic cluster-randomised, controlled trial, we randomly allocated primary...

10.1016/s0140-6736(23)01573-8 article EN cc-by The Lancet 2023-10-01
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