A5071521824- HIV/AIDS Research and Interventions
- Tuberculosis Research and Epidemiology
- Global Maternal and Child Health
- Adolescent Sexual and Reproductive Health
- HIV, Drug Use, Sexual Risk
- HIV/AIDS Impact and Responses
- HIV-related health complications and treatments
- HIV Research and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS drug development and treatment
- Hepatitis B Virus Studies
- Mycobacterium research and diagnosis
- Child Nutrition and Water Access
- Poverty, Education, and Child Welfare
- Global Public Health Policies and Epidemiology
- Global Health Care Issues
- Hepatitis C virus research
- Breastfeeding Practices and Influences
- Vaccine Coverage and Hesitancy
- Diagnosis and treatment of tuberculosis
- Health disparities and outcomes
- Mental Health Treatment and Access
- Maternal Mental Health During Pregnancy and Postpartum
- Health Systems, Economic Evaluations, Quality of Life
- Viral Infections and Outbreaks Research
Albert Einstein College of Medicine
2020-2025
Montefiore Medical Center
2020-2024
General Department of Preventive Medicine
2021-2024
The Ohio State University
2014-2023
Yeshiva University
2021-2023
University of Kinshasa
2013-2023
University of North Carolina at Chapel Hill
2009-2022
Center for Global Health
2022
Montefiore Health System
2021-2022
Weatherford College
2020
Background Globally, the population of adolescents living with perinatally acquired HIV (APHs) continues to expand. In this study, we pooled data from observational pediatric cohorts and cohort networks, allowing comparisons in "real-life" settings across multiple regions. We describe geographic temporal characteristics mortality outcomes APHs regions, including South America Caribbean, North America, Europe, sub-Saharan Africa, Southeast Asia. Methods findings Through Collaborative...
Abstract Introduction: The number of adolescents with perinatally or behaviourally acquired HIV is increasing in low‐income countries, and especially sub‐Saharan Africa where prevalence incidence are the highest. As they survive into adulthood era antiretroviral therapy, there a pressing need to transfer them from paediatric adult care, known as transition care. We conducted narrative review recent evidence on their outcomes Africa, highlighting specific needs challenges these populations...
The effect of highly active antiretroviral therapy (HAART) on the survival HIV-infected children has not been well quantified. Because most pediatric HIV occurs in low- and middle-income countries, our objective was to provide a first estimate this among living resource-deprived setting.
Early initiation of combination antiretroviral therapy (cART), at higher CD4 cell counts, prevents disease progression and reduces sexual transmission human immunodeficiency virus (HIV). We describe the temporal trends in counts start cART adults from low-income, lower-middle-income, upper-middle-income, high-income countries (LICs, LMICs, UMICs, HICs, respectively).We included HIV-infected individuals aged ≥16 years who started between 2002 2015 a clinic participating International...
BackgroundOptimisation of breastfeeding practices could reduce high mortality rates in children younger than 5 years, but DR Congo, despite near-universal initiation and nine ten still at 1 year age, exclusivity remains a difficulty. We assessed the effect on outcomes short-cut implementation programme called Ten Steps to Successful Breastfeeding, key component Baby-Friendly Hospital Initiative (BFHI).MethodsWe did cluster-randomised controlled trial randomly assigned health-care clinics...
Whole-genome sequencing allows rapid detection of drug-resistant Mycobacterium tuberculosis isolates. However, the availability high-quality data linking quantitative phenotypic drug susceptibility testing (DST) and genomic have thus far been limited.
Abstract Introduction We assessed mortality and losses to follow‐up ( LTFU ) during adolescence in routine care settings the International epidemiology Databases Evaluate AIDS (Ie DEA consortium. Methods Cohorts Asia‐Pacific, Caribbean, Central, South America, sub‐Saharan Africa (Central, East, Southern, West) contributed data, included adolescents living with HIV ALHIV enrolled from January 2003 aged 10 19 years (period of adolescence) while under up database closure (June 2016). Follow‐up...
BackgroundHepatitis B virus (HBV) remains endemic throughout sub-Saharan Africa despite the widespread availability of effective childhood vaccines. In Democratic Republic Congo, HBV treatment and birth-dose vaccination programmes are not established. We, therefore, aimed to evaluate feasibility acceptability adding testing pregnant women as well HBV-exposed infants HIV prevention mother-to-child transmission programme infrastructure in Congo.MethodsWe did a study two maternity centres...
Background: Novel strategies are needed to increase retention in prevention of mother-to-child HIV transmission (PMTCT) services. We have recently shown that small, incremental cash transfers conditional on attending clinic resulted increased along the PMTCT cascade. However, whether women who receive incentives attend visits as adherent antiretrovirals (ARV) those do not was unknown. Objective: To determine HIV-infected received remain care were antiretroviral treatment and achieved same...
Drug resistance threatens global tuberculosis control. We aimed to examine mortality in patients with from high-burden countries, according concordance or discordance of results drug susceptibility testing done locally and whole-genome sequencing (WGS). In this multicentre cohort study, we collected pulmonary Mycobacterium isolates clinical data individuals antiretroviral therapy programmes clinics Côte d'Ivoire, Democratic Republic the Congo, Kenya, Nigeria, Peru, South Africa, Thailand,...
Abstract Background The World Health Organization Africa region has high regional hepatitis B virus (HBV) prevalence, and evidence suggests more frequent horizontal HBV transmission than other regions. Context-specific epidemiological studies are needed to inform additional prevention measures. Methods In the cross-sectional Horizontal Vertical Transmission of Hepatitis (HOVER-HBV) study, we introduced surface antigen (HBsAg) screening alongside existing HIV as part routine antenatal care in...
Tuberculosis (TB) is a leading infectious cause of death globally. It the most common opportunistic infection in people living with HIV, and their morbidity mortality. Following TB treatment, surviving individuals may be at risk for post-TB lung disease. The Sentinel Research Network (TB-SRN) provides platform coordinated observational research within International epidemiology Databases to Evaluate AIDS (IeDEA) consortium. This prospective, cohort study will assess treatment post-treatment...
Islatravir (ISL) is a novel antiretroviral that inhibits HIV-1 reverse transcriptase translocation. The M184V mutation, known to reduce ISL’s viral susceptibility in vitro, could arise from prolonged exposure nucleoside inhibitors (NRTI) (3TC). This study evaluated the predictive efficacy of ISL and identified potentially active antiretrovirals combination among treatment-experienced patients Cameroon, where NRTIs (3TC) have been backbone ART for decades now. Although long-acting...
Background The COVID-19 pandemic challenged healthcare systems, particularly in settings with high infectious disease burden. We examined the postpandemic long-term impacts of on tuberculosis (TB) services at anti-retroviral therapy (ART) clinics lower-income countries. Methods Using standardised online questionnaires, we conducted a cross-sectional site survey among ART providing TB Africa and Asia from July to September 2023 (site-level information number diagnoses tests). Results Of 45...