A5054490440- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Viral Infections and Outbreaks Research
- Zoonotic diseases and public health
- SARS-CoV-2 and COVID-19 Research
- Global Public Health Policies and Epidemiology
- Poxvirus research and outbreaks
- Vaccine Coverage and Hesitancy
- Bacillus and Francisella bacterial research
- SARS-CoV-2 detection and testing
- COVID-19 epidemiological studies
- Viral Infections and Vectors
- Healthcare Systems and Reforms
- COVID-19 and Mental Health
- COVID-19 diagnosis using AI
- COVID-19 Clinical Research Studies
- Pharmaceutical Economics and Policy
- Mosquito-borne diseases and control
- Climate Change and Health Impacts
- Disaster Response and Management
- Herpesvirus Infections and Treatments
- Virology and Viral Diseases
- Global Health and Surgery
- Pneumocystis jirovecii pneumonia detection and treatment
Africa Centres for Disease Control and Prevention
2021-2025
University of Maryland, Baltimore
2011-2025
University of Maryland, College Park
2025
Kanazawa University
2009-2024
French Institute for Research in Africa
2022-2024
Institute of Human Virology
2012-2023
African Union Commission
2021-2023
Health Affairs
2022-2023
Centre International De Reference Chantal Biya
2023
Amref Health Africa
2023
<h2>Summary</h2><h3>Background</h3> Antiretroviral therapy (ART) is crucial for controlling HIV-1 infection through wide-scale treatment as prevention and pre-exposure prophylaxis (PrEP). Potent tenofovir disoproxil fumarate-containing regimens are increasingly used to treat prevent HIV, although few data exist frequency risk factors of acquired drug resistance in regions hardest hit by the HIV pandemic. We aimed do a global assessment after virological failure with first-line...
Mpox was previously thought to be a zoonotic disease endemic in parts of central, west, and east Africa; however, from 2022 2023, large global outbreak mpox clade II monkeypox virus occurred, marking the first instance sustained transmission outside Africa since case human identified 1970.1WHOMonkeypox – United Kingdom Great Britain Northern Ireland.https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON383Date: May 18, 2022Date accessed: March 24, 2024Google Scholar More...
For decades after the identification of mpox in humans Democratic Republic Congo (DRC) 1970, disease was largely confined to rural areas Central and West Africa thus did not garner broad attention. On August 13, 2024, declared a Public Health Emergency Continental Security (PHECS) by Centers for Disease Control Prevention (Africa CDC), notice that followed next day declaration International Concern (PHEIC) World Organization. In this study we analyzed all cases deaths, based on clinical or...
Abstract Background The COVID-19 vaccine supply shortage in 2021 constrained roll-out efforts Africa while populations experienced waves of epidemics. As improves, a key question is whether vaccination remains an impactful and cost-effective strategy given changes the timing implementation. Methods We assessed impact programme using epidemiological economic model. fitted age-specific dynamic transmission model to reported deaths 27 African countries approximate existing immunity resulting...
The increasing prevalence of acquired and transmitted HIV-1 drug resistance is an obstacle to successful antiretroviral therapy (ART) in the low- middle-income countries (LMICs) hardest hit by pandemic. Genotypic testing could facilitate choice initial ART areas with rising (TDR) enable care-providers determine which individuals virological failure (VF) on a first- or second-line regimen require change treatment. An inexpensive near point-of-care (POC) genotypic test would be useful settings...
BackgroundHIV-1 drug resistance to older thymidine analogue nucleoside reverse transcriptase inhibitor drugs has been identified in sub-Saharan Africa patients with virological failure of first-line combination antiretroviral therapy (ART) containing the modern tenofovir. We aimed investigate prevalence and correlates mutations (TAM) tenofovir-containing ART.MethodsWe retrospectively analysed from 20 studies within TenoRes collaboration who had locally defined viral on tenofovir plus a...
Introduction An increased incidence of human Monkeypox (Mpox) cases was recently observed worldwide, including in Cameroon. To ensure efficient preparedness and interventions the health system, we sought to assess knowledge Mpox's transmission, prevention, response among healthcare workers (HCWs) Methods A cross-sectional online survey conducted HCWs Cameroon using 21-item questions adapted from United States Centers for Disease Control Prevention (US-CDC) standard questionnaire on Mpox. The...
The African continent demonstrated decisive leadership throughout its response to the COVID-19 pandemic, leveraging lessons learned from previous outbreaks and acting quickly limit impact of SARS-CoV-2 virus. We propose a framework build on these successes that calls for greater collaboration between leaders, inclusion voices in global health ecosystem.
Objectives: Marburg virus disease (MVD) is on the WHO list for pandemic-prone pathogens. The current outbreak in Rwanda provides an opportunity to map outbreaks and generate information inform policymaking, resource mobilization, guide implementation of cost-effective response strategies. Methods: We synthesized available about MVD build holistic, up-to-date evidence policymakers, public health leaders, healthcare services providers their development preparedness, prevention, control...
Enhancing the clinical trial capabilities within Africa is essential to augment continent's pandemic prevention, preparedness and response efforts. Here, we describe critical challenges of trials in draw upon lessons learnt from Consortium for COVID-19 Vaccine Clinical Trials (CONCVACT) experience, such as importance regional collaboration, capacity building establishing standardized protocols.
Objective: To assess the emergence of transmitted HIV-1 drug resistance (TDR) in Kampala, Uganda, 10 years after scale-up antiretroviral treatment (ART) and to compare with a previous survey among antenatal clinic attendees 2007 (reporting 0% TDR). Design: A cross-sectional was conducted newly diagnosed, antiretroviral-naive young adults attending two large voluntary counseling testing centers within geographic area Kampala. Methods: Proxy criteria for recent infection were used as defined...
Islatravir (ISL) is a novel antiretroviral that inhibits HIV-1 reverse transcriptase translocation. The M184V mutation, known to reduce ISL’s viral susceptibility in vitro, could arise from prolonged exposure nucleoside inhibitors (NRTI) (3TC). This study evaluated the predictive efficacy of ISL and identified potentially active antiretrovirals combination among treatment-experienced patients Cameroon, where NRTIs (3TC) have been backbone ART for decades now. Although long-acting...
An increasing number of people living with HIV (PLHIV) are failing treatment without drug resistance in the target region. While sub-optimal adherence is likely cause failure many PLHIV, emerging at non-canonical (HIV mutations occurring outside site) site sites also plausible. Non-canonical mechanisms have been identified for integrase strand transfer inhibitors (INSTIs), protease (PIs), non-nucleoside reverse transcriptase (NNRTIs) and NRTIs. Overall, they may act by i) restoring viral...
With the advent of COVID-19, anti-SARS-CoV-2 vaccines were a global health priority, but evidence on their significance within tropical settings remained limited. We sought to assess distribution antibodies according vaccine status and types administered in Cameroon during Omicron waves. A community based cross-sectional sero-survey was conducted from February-15 through July-31 2022 among individuals tested for COVID-19 Yaoundé-Cameroon. Sociodemographic data collected participants....
Due to the sudden emergence and burnout nature of Marburg virus (MARV) outbreaks, little is known about MARV’s pathogenicity immunogenicity. These gaps in knowledge are limiting our understanding disease implementation cost-effective prevention control measures including case management through safe effective therapeutic modalities. Therefore, this review aims synthesize summarize evidence pathogenicity, immunogenicity, virulence humans towards MARV. Upon infection, MARV rapidly disseminates...
Africa faces again a new outbreak of mpox, heavily burdening the Democratic Republic Congo (DRC). Factors such as biological and ecological changes in virus, waning immunity to smallpox, socio-economic challenges, global economic strain are fueling this epidemic. To analyse drivers mpox DRC, review international local response, draw lessons from COVID-19 pandemic propose strategies for building epidemic-resilient healthcare systems region. The focus is on where epidemic concentrated, broader...