A5021278787- Poxvirus research and outbreaks
- Bacillus and Francisella bacterial research
- Viral Infections and Outbreaks Research
- Antimicrobial Peptides and Activities
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- Zoonotic diseases and public health
- Herpesvirus Infections and Treatments
- Influenza Virus Research Studies
- Immune Response and Inflammation
- COVID-19 epidemiological studies
- COVID-19 Clinical Research Studies
- Virology and Viral Diseases
- Animal Virus Infections Studies
- Hepatitis B Virus Studies
- Rabies epidemiology and control
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Vaccine Coverage and Hesitancy
- Advanced Proteomics Techniques and Applications
- Animal Disease Management and Epidemiology
- Enzyme Structure and Function
- Chemical Synthesis and Analysis
- Disaster Response and Management
- Pneumonia and Respiratory Infections
University of Manitoba
2017-2025
Children's Hospital Research Institute of Manitoba
2023-2025
National Institute of Allergy and Infectious Diseases
2011-2023
National Institutes of Health
2010-2023
Research Manitoba
2023
University of Saskatchewan
2001-2021
National Institutes of Health Clinical Center
2016-2020
Children's National
2017
Frederick National Laboratory for Cancer Research
2016
University of British Columbia
2009-2012
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Outbreaks of emerging infections present health professionals with the unique challenge trying to select appropriate pharmacologic treatments in clinic little time available for drug testing and development. Typically, clinicians are left general supportive care often untested convalescent-phase plasma as treatment options. Repurposing approved pharmaceutical drugs new indications presents an attractive alternative clinicians, researchers, public agencies, developers, funding agencies. Given...
ABSTRACT Middle East respiratory syndrome coronavirus (MERS-CoV) is a lineage C betacoronavirus, and infections with this virus can result in acute renal failure. Globally, MERS-CoV has been responsible for 877 laboratory-confirmed infections, including 317 deaths, since September 2012. As there paucity of information regarding the molecular pathogenesis associated or identities novel antiviral drug targets, we performed temporal kinome analysis on human hepatocytes infected Erasmus isolate...
On 31 December 2019 the Wuhan Health Commission reported a cluster of atypical pneumonia cases that was linked to wet market in city Wuhan, China. The first patients began experiencing symptoms illness mid-December 2019. Clinical isolates were found contain novel coronavirus with similarity bat coronaviruses. As 28 January 2020, there are excess 4,500 laboratory-confirmed cases, > 100 known deaths. SARS-CoV, infections children appear be rare. Travel-related have been confirmed multiple...
The Middle East respiratory syndrome coronavirus (MERS-CoV) presents a novel emerging threat to public health worldwide. Several treatments for infected individuals have been suggested including IFN, ribavirin and passive immunotherapy with convalescent plasma. Administration of IFN-α2b has improved outcomes MERS-CoV infection in rhesus macaques when administered within 8 h post-challenge. However, detailed systematic evidence on the activity other clinically available drugs is limited. Here...
Outbreaks of monkeypox (mpox) have historically resulted from zoonotic spillover clade I virus (MPXV) in Central Africa and II MPXV West Africa. In 2022, subclade IIb caused a global epidemic linked to transmission through sexual contact. Here we describe the epidemiological genomic features an mpox outbreak mining region eastern Democratic Republic Congo, by MPXV. Surveillance data collected between September 2023 January 2024 identified 241 suspected cases. Genomic analysis demonstrates...
We report a cluster of clade I monkeypox virus infections linked to sexual contact in the Democratic Republic Congo. Case investigations resulted 5 reverse transcription PCR-confirmed infections; genome sequencing suggest they belonged same transmission chain. This finding demonstrates that mpox through extends beyond IIb.
ABSTRACT Background Monkeypox virus (MPXV) attracted global attention in 2022 during a widespread outbreak linked primarily to sexual contact. Clade I MPXV is prevalent Central Africa and characterized by severe disease high mortality, while II confined West associated with milder illness. A IIb emerged Nigeria 2017, protracted human-to-human transmission forerunner of the B.1 lineage 2022. In October 2023, large mpox Kamituga mining region Democratic Republic Congo (DRC), which we conducted...
Mpox was previously thought to be a zoonotic disease endemic in parts of central, west, and east Africa; however, from 2022 2023, large global outbreak mpox clade II monkeypox virus occurred, marking the first instance sustained transmission outside Africa since case human identified 1970.1WHOMonkeypox – United Kingdom Great Britain Northern Ireland.https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON383Date: May 18, 2022Date accessed: March 24, 2024Google Scholar More...
Recent reports raise concerns on the changing epidemiology of mpox in Democratic Republic Congo (DRC). High-quality genomes were generated for 337 patients from 14/26 provinces to document whether increase number cases is due zoonotic spillover events or viral evolution, with enrichment APOBEC3 mutations linked human adaptation. Our study highlights two patterns transmission contributing source cases. All new sequences eastern South Kivu province (n = 17; 4.8%) corresponded recently...
Abstract With the rapid rise in incidence of multidrug resistant infections, there is substantial interest host defense peptides as templates for production new antimicrobial therapeutics. Natural are multifunctional mediators innate immune response, with some direct activity and diverse immunomodulatory properties. We have previously developed an regulator (IDR) 1, protective against bacterial infection mediated entirely through its effects on immunity host, a novel approach to...
Abstract The human cationic host defense peptide LL-37 has a broad range of immunomodulatory, anti-infective functions. A synthetic innate regulator peptide, 1 (IDR-1), based conceptually on LL-37, was recently shown to selectively modulate immunity protect against wide bacterial infections. Using advanced proteomic techniques, ELISA, and Western blotting procedures, GAPDH identified as direct binding partner for in monocytes. Enzyme kinetics mobility shift studies also indicated IDR-1...
Primary amine containing copolymer, poly(N,N-dimethylacrylamide-co-N-(3-aminopropyl)methacrylamide hydrochloride) (poly(DMA-co-APMA)), brushes were synthesized on Ti surface by surface-initiated atom transfer radical polymerization (SI-ATRP) in aqueous conditions. A series of poly(DMA-co-APMA) copolymer titanium (Ti) with different molecular weights, thicknesses, compositions, and graft densities changing the SI-ATRP reaction Cysteine-functionalized cationic antimicrobial peptide Tet213...
Innate defense regulators (IDRs) are synthetic immunomodulatory versions of natural host peptides (HDP). IDRs mediate protection against bacterial challenge in the absence direct antimicrobial activity, representing a novel approach to anti-infective and anti-inflammatory therapy. Previously, we reported that IDR-1018 selectively induced chemokine responses suppressed pro-inflammatory responses. As there has been an increasing appreciation for ability HDPs modulate complex immune processes,...
Innate immunity is triggered by a variety of bacterial molecules, resulting in both protective and potentially harmful pro-inflammatory responses. Further, innate also provides mechanism for the maintenance homeostasis between host immune system symbiotic or non-pathogenic microorganisms. However, factors that mediate these effects have been incompletely defined. Here, it was demonstrated lantiobiotic nisin Z able to modulate responses immunity. Nisin induced secretion chemokines MCP-1, IL-8...