A5044320570- Viral Infections and Outbreaks Research
- SARS-CoV-2 and COVID-19 Research
- Disaster Response and Management
- COVID-19 epidemiological studies
- Viral Infections and Vectors
- COVID-19 Clinical Research Studies
- Poxvirus research and outbreaks
- SARS-CoV-2 detection and testing
- Mosquito-borne diseases and control
- Zoonotic diseases and public health
- Bacillus and Francisella bacterial research
- Herpesvirus Infections and Treatments
- COVID-19 diagnosis using AI
- Dengue and Mosquito Control Research
- Hepatitis B Virus Studies
- Virology and Viral Diseases
- Rabies epidemiology and control
- Immune responses and vaccinations
- Vaccine Coverage and Hesitancy
- Data-Driven Disease Surveillance
- Viral Infections and Immunology Research
- Plant Virus Research Studies
- Malaria Research and Control
- Peripheral Neuropathies and Disorders
Institut de Recherche pour le Développement
2020-2024
Université de Montpellier
2020-2024
National Institute of Biomedical Research
2020-2024
University of Kinshasa
2020-2024
Inserm
2020-2024
Agropolis International
2020
Recherches Translationnelles sur le VIH et les Maladies Infectieuses
2020
Recent reports raise concerns on the changing epidemiology of mpox in Democratic Republic Congo (DRC). High-quality genomes were generated for 337 patients from 14/26 provinces to document whether increase number cases is due zoonotic spillover events or viral evolution, with enrichment APOBEC3 mutations linked human adaptation. Our study highlights two patterns transmission contributing source cases. All new sequences eastern South Kivu province (n = 17; 4.8%) corresponded recently...
During the 2018-2020 Ebola virus disease (EVD) outbreak in North Kivu province Democratic Republic of Congo, EVD was diagnosed a patient who had received recombinant vesicular stomatitis virus-based vaccine expressing ZEBOV glycoprotein (rVSV-ZEBOV) (Merck).His treatment included an (EBOV)-specific monoclonal antibody (mAb114), and he recovered within 14 days.However, 6 months later, presented again with severe EVD-like illness EBOV viremia, died.We initiated epidemiologic genomic...
Knowledge of the COVID-19 epidemic extent and level herd immunity is urgently needed to help manage this pandemic.
Between January and August 2024, mpox cases have been reported in nearly all provinces of the Democratic Republic Congo (DRC). Monkeypox virus genome sequences were obtained from 11 cases’ samples, collected July–August 2024 several health zones Kinshasa. Characterisation showed subclades Ia Ib co-circulating Limete zone, while phylogenetic analyses suggested multiple introductions two This illustrates growing complexity Clade I outbreaks DRC.
Abstract Background In October 2020, after the first wave of coronavirus disease 2019 (COVID-19), only 8290 confirmed cases were reported in Kinshasa, Democratic Republic Congo, but real prevalence remains unknown. To guide public health policies, we aimed to describe severe acute respiratory syndrome 2 (SARS-CoV-2) immunoglobulin G (IgG) antibodies general population Kinshasa. Methods We conducted a cross-sectional, household-based serosurvey between 22 2020 and 8 November 2020....
Human Mpox cases are increasingly reported in Africa, with the highest burden Democratic Republic of Congo (DRC). While case reporting on a clinical basis can overestimate infection rates, laboratory confirmation by PCR underestimate them, especially suboptimal samples like blood, commonly used DRC. Here we Luminex-based assay to evaluate whether antibody testing be complementary confirm and identify human transmission chains during outbreak investigations. We left-over blood from 463...
Zoonoses can constitute a threat for public health that have global importance, as seen with the current COVID-19 pandemic of severe acute respiratory syndrome coronavirus (SARS-CoV2). Bats been recognized an important reservoir zoonotic coronaviruses (CoVs). In West Africa, where there is high diversity bat species, little known on circulation CoVs in these hosts, especially at interface human populations. this study, Guinea, we tested total 319 bats belonging to 14 genera and six families...
Early 2019, a chikungunya virus (CHIKV) outbreak hit the Democratic Republic of Congo (DRC). Though seldomly deadly, this mosquito-borne disease presents as an acute febrile (poly)arthralgia often followed by long-term sequelae. Although Aedes aegypti is primary vector, amino acid substitution in viral envelope gene E1 (A226V) causing concern it results increased transmission albopictus, mosquito with much wider geographical distribution. Between January and March we collected human samples...
Abstract Background Survivors from Ebola virus disease (EVD) may be at the origin of EVD resurgence. Methods Simultaneous reactivity to least 2 or Zaire ebolavirus (EBOV) antigens was detected in 11 488 (2.3%; 95% confidence interval [CI], 1.1–4.0) suspected patients who were discharged as negative after consecutive tests during 10th outbreak Democratic Republic Congo. Results After extrapolating total number individuals entire outbreak, we estimated a 1314 additional missed cases....
Early March 2019, health authorities of Matadi in the Democratic Republic Congo alerted a sudden increase acute fever/arthralgia cases, prompting an outbreak investigation. We collected surveillance data, clinical and laboratory specimens from suspects (for CHIKV-PCR/ELISA, malaria RDT), semi-structured interviews with patients/caregivers about perceptions seeking behavior, mosquito sampling (adult/larvae) for CHIKV-PCR estimation infestation levels. The investigations confirmed large CHIKV...
Abstract High-throughput serological tests that can detect neutralizing antibodies against SARS-CoV-2 are desirable for serosurveillance and vaccine efficacy evaluation. Although the conventional neutralization test (cVNT) remains gold standard to confirm presence of in sera, is too labour-intensive massive screening programs less reproducible as live virus cell culture involved. Here, we performed an independent evaluation a commercially available surrogate (sVNT, GenScript cPass ™ ) be...
Polio-associated paralysis is one of the diseases under national surveillance in Democratic Republic Congo (DRC). Although it has become relatively rare due to control measures, non-polio cases are still reported and constitute a real problem, especially for etiological diagnosis, which necessary better management response. From September 2022 April 2023, we investigated acute flaccid (AFP) Kinshasa following an alert from Provincial Division Health. All suspected their close contacts were...
Abstract Introduction Serological surveys offer the most direct measurement to define immunity status for numerous infectious diseases, such as COVID-19, and can provide valuable insights into understanding transmission patterns. This study describes seroprevalence changes over time in context of Democratic Republic Congo, where COVID-19 case presentation was apparently largely oligo- or asymptomatic, vaccination coverage remained extremely low. Methods A cohort 635 health care workers (HCW)...
During the 2018-20 Ebola virus disease outbreak in Democratic Republic of Congo, thousands patients received unprecedented vaccination, monoclonal antibody (mAb) therapy, or both, leading to a large number survivors. We aimed report clinical, virological, viral genomic, and immunological features two previously vaccinated mAb-treated survivors Congo who developed second episodes months after initial discharge, ultimately complicated by fatal meningoencephalitis associated with persistence.
Abstract Mpox cases have been reported in nearly all provinces of the Democratic Republic Congo as August 2024. Monkeypox virus positive samples from Kinshasa, collected between July and mid-August 2024, were sequenced using a probe-based enrichment or optimized tiling sequencing protocol. With multiple introductions both Clade Ia (7/12) Ib (5/12), marking its Limete health zone specifically, an area with co-circulation I, unique observation illustrating growing complexity I mpox outbreaks DRC.
Background: Few evidence exists about the degree of seroconversion and seroreversion SARS-CoV-2 in sub-Saharan Africa, where COVID-19 case presentation is apparently largely oligo- or asymptomatic.Methods: A cohort 561 health care workers from 5 zones Kinshasa was followed up between July 2020 January 2021, with 6-8 weeks intervals. At each visit, information on risk exposure a blood sample collected. Serology defined as positive when binding antibodies against spike (S) nucleocapsid...