A5020115826- Influenza Virus Research Studies
- Respiratory viral infections research
- Viral Infections and Outbreaks Research
- COVID-19 epidemiological studies
- Vaccine Coverage and Hesitancy
- Data-Driven Disease Surveillance
- SARS-CoV-2 and COVID-19 Research
- Bacillus and Francisella bacterial research
- Vibrio bacteria research studies
- Disaster Response and Management
- Poxvirus research and outbreaks
- Hepatitis B Virus Studies
- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
- Viral Infections and Vectors
- Virology and Viral Diseases
- Viral Infections and Immunology Research
- COVID-19 Impact on Reproduction
- COVID-19 and healthcare impacts
- Mosquito-borne diseases and control
- Rabies epidemiology and control
- Whipple's Disease and Interleukins
- Pregnancy and preeclampsia studies
- Viral gastroenteritis research and epidemiology
- vaccines and immunoinformatics approaches
National Institute of Biomedical Research
2018-2024
University of Goma
2023-2024
University of Zambia
2018
Recent reports raise concerns on the changing epidemiology of mpox in Democratic Republic Congo (DRC). High-quality genomes were generated for 337 patients from 14/26 provinces to document whether increase number cases is due zoonotic spillover events or viral evolution, with enrichment APOBEC3 mutations linked human adaptation. Our study highlights two patterns transmission contributing source cases. All new sequences eastern South Kivu province (n = 17; 4.8%) corresponded recently...
BackgroundA global shortage of cholera vaccines has increased the use single-dose regimens, rather than standard two-dose regimen. There is sparse evidence on protection, particularly in children. In 2020, a mass vaccination campaign was conducted Uvira, an endemic urban setting eastern Democratic Republic Congo, resulting largely coverage. We examined effectiveness oral vaccine Euvichol-Plus this high-burden setting.MethodsIn matched case-control study, we recruited individuals with...
ABSTRACT Background Recent reports raise concerns on the changing epidemiology of mpox in Democratic Republic Congo (DRC), with increasing case counts, sexual contact-mediated clusters, and sustained human-to-human transmission driven by a novel monkeypox virus (MPXV) subclade, clade Ib. However, only limited number I MPXV genomes have been characterized so far, from regions. Methods We conducted whole genome sequencing 603 mpox-positive samples that were collected 581 patients between...
BackgroundThe Democratic Republic of the Congo has had 15 Ebola virus disease (EVD) outbreaks, from 1976 to 2023. On June 1, 2020, declared an outbreak EVD in western Équateur Province (11th outbreak), proximal 2018 Tumba and Bikoro concurrent with eastern Nord Kivu Province. In this Article, we assessed whether 11th was genetically related previous or outbreaks connected available epidemiological genetic data identify sources possible zoonotic spillover, uncover additional unreported cases...
Ebola virus disease (EVD) continues to be a significant public health problem in sub-Saharan Africa, especially the Democratic Republic of Congo (DRC). Large-scale vaccination during outbreaks may reduce transmission. We established large population-based clinical trial heterologous, two-dose prophylactic vaccine an outbreak eastern DRC determine effectiveness.This open-label, non-randomised, enrolled eligible adults and children aged 1 year above. Participants were offered candidate EVD...
Abstract Background The World Health Organization recommends periodic evaluations of influenza surveillance systems to identify areas for improvement and provide evidence data reliability policymaking. However, about the performance established are limited in Africa, including Democratic Republic Congo (DRC). Methods We used Centers Disease Control Prevention guidelines evaluate sentinel system (ISSS) DRC during 2012–2015. was evaluated using eight attributes: (i) quality completeness key...
Introduction This study aimed to determine whether the COVID-19 pandemic had an impact on essential primary healthcare services at public facilities. Methods The number of weekly consultations for antenatal care (ANC), outpatient (OPD), immunisations (EPI), family planning (FP) and HIV services, between January 2018 December 2020, were collected from 25 facilities in Masaka district, Uganda, 21 Goma, 29 Kambia Sierra Leone. Negative binomial regression models accounting clustering season...
The last confirmed wild poliovirus (WPV) case in Democratic Republic of the Congo (DRC) had paralysis onset December 2011 (1). DRC has cases vaccine-derived polioviruses (VDPVs) documented since 2004 (Table 1) (1-6). After an outbreak 30 circulating VDPV type 2 (cVDPV2) during 2011-2012, only five VDPV2 were reported 2013-2016 VDPVs can emerge from oral vaccine (OPV types 1, 2, or 3; Sabin) that have genetically mutated resulting reversion to neurovirulence. This process occurs extensive...
Worldwide, the highest malaria mortality is due to Plasmodium falciparum infection. However, other species of (Plasmodium vivax, ovale, malariae, and knowlesi) can also cause malaria. Therefore, accurate identification crucial for patient management epidemiological surveillance. This study aimed determine different causing in children under 5 years old two provinces (Kinshasa North Kivu) Democratic Republic Congo (DRC). From October December 2015, a health-facility based cross-sectional was...
During the 10th Ebola virus disease (EVD) epidemic in eastern Democratic Republic of Congo (DRC) (2018-2020), two experimental EVD vaccines were deployed North Kivu. This province has been at centre conflict region for last 25 years. Amidst ambivalence towards protracted foreign intervention and controversy about introducing vaccines, existing literature focused on mistrust 'resistance' response vaccines. In this article, we examine why people DRC did decide to volunteer a trial second...
Our understanding of the burden and drivers cholera mortality is hampered by limited surveillance confirmation capacity. Leveraging enhanced clinical laboratory in cholera-endemic community Uvira, eastern Democratic Republic Congo, we describe deaths across 3 epidemics between September 2021 2023 following mass vaccination.
Estimates of influenza-associated outpatient consultations and hospitalizations are severely limited in low- middle-income countries, especially Africa. We conducted active prospective surveillance for influenza-like illness (ILI) severe acute respiratory (SARI) at 5 healthcare facilities situated Kinshasa Province during 2013-2015. tested upper tract samples influenza viruses using a reverse transcription-polymerase chain reaction assay. estimated age-specific numbers rates ILI SARI...
During the 2018-2020 Ebola virus disease (EVD) outbreak, residents in Goma, Democratic Republic of Congo, were offered a two-dose prophylactic EVD vaccine. This was first study to evaluate safety this vaccine pregnant women. Adults, including women, and children aged ≥1 year old Ad26.ZEBOV (day 0; dose 1), MVA-BN-Filo 56; 2) through an open-label clinical trial. In total, 20,408 participants, 6635 (32.5%) children, received 1. Fewer than 1% non-pregnant participants experienced serious...
Summary Background The ongoing outbreaks of mpox, the disease caused by monkeypox virus (MPXV) highlight urgent need for a rapid and low-cost MPXV diagnostic test to accurately detect control mpox disease. In this study we assessed accuracy three brands tests antigen detection (Ag–RDT) MPXV. Methods We estimated clinical performance FlowFlex Monkeypox Virus Antigen Rapid Test (ACON Biotech Co., Ltd., Hangzhou, China), Ecotest (Assure Tech. Ltd, STANDARD Q Ag (SD Biosensor, Inc. Republic...
Enteroviruses (EVs) are among the most common viruses infecting humans worldwide but only a few Non-Polio Enterovirus (NPEV) isolates have been characterized in Democratic Republic of Congo (DR Congo). Moreover, circulating vaccine-derived polioviruses (PVs) [cVDPVs] isolated during multiple outbreaks DR from 2004 to 2018 so far by sequences their VP1 capsid coding gene. This study was carried i) investigate circulation and genetic diversity NPEV polio vaccine recovered healthy children...
Abstract Background Influenza surveillance helps time prevention and control interventions especially where complex seasonal patterns exist. We assessed influenza sustainability in Africa activity varies external funds for have decreased. Methods surveyed African Network Surveillance Epidemiology ( ANISE) countries about 2011‐2017 system characteristics. Data were summarized with descriptive statistics analyzed univariate multivariable analyses to quantify sustained or expanded capacity...
This article examines the experience of healthcare professionals working in primary provision during first wave COVID-19 pandemic North Kivu, Democratic Republic Congo, and Kambia District, Sierra Leone. Drawing on ethnographic observation, interviews focus groups, we explore everyday narratives ‘crisis’ these two regions which had recently seen Ebola epidemics. In describing impact their life, work, relationships with patients, workers made sense relation to broader experiences structural...
Introduction The establishment of the influenza sentinel surveillance system in Kinshasa, Bas Congo, Maniema, Katanga, and Kasai Provinces allowed generation important data on molecular epidemiology human viruses circulating Democratic Republic Congo (DRC). However, some challenges still exist, including need for extending to more provinces. This study describes pattern virus DRC during 2015. Methodology Nasopharyngeal swabs were collected from January December 2015 outpatients with...
ObjectivesWe assessed the prevalence of immunoglobulin G (IgG) and IgM against four endemic human coronaviruses two SARS-CoV-2 antigens among vaccinated unvaccinated staff at health care centers in Uganda, Sierra Leone, Democratic Republic Congo.MethodsThe government facility who had patient contact Goma (Democratic Congo), Kambia District (Sierra Leone), Masaka (Uganda) were enrolled. Questionnaires blood samples collected three time points over 4 months. Blood analyzed with Luminex...
Abstract Background The World Health Organization recommends periodic evaluations of influenza surveillance systems to identify areas for improvement and provide evidence data reliability policymaking. However, about the performance established are limited in Africa, including Democratic Republic Congo (DRC). Methods We used Centers Disease Control Prevention guidelines evaluate sentinel system (ISSS) DRC during 2012-2015. was evaluated using eight attributes: (i) quality completeness key...
During the 2018–2020 Ebola virus disease outbreak in Democratic Republic of Congo, a phase 3 trial Ad26.ZEBOV, MVA-BN-Filo vaccine (DRC-EB-001) commenced Goma, with participants being offered two-dose regimen given 56 days apart. Suspension activities 2020 due to COVID-19 pandemic led some receiving late dose 2 outside planned interval. Blood samples were collected from adults, adolescents, and children prior their delayed vaccination 21 after, tested for IgG binding antibodies against...
During the 2018-20 Ebola virus disease outbreak in Democratic Republic of Congo, thousands patients received unprecedented vaccination, monoclonal antibody (mAb) therapy, or both, leading to a large number survivors. We aimed report clinical, virological, viral genomic, and immunological features two previously vaccinated mAb-treated survivors Congo who developed second episodes months after initial discharge, ultimately complicated by fatal meningoencephalitis associated with persistence.