Samba O. Sow
A5057901946- Pneumonia and Respiratory Infections
- Viral gastroenteritis research and epidemiology
- Child Nutrition and Water Access
- Bacterial Infections and Vaccines
- Respiratory viral infections research
- Vaccine Coverage and Hesitancy
- Global Maternal and Child Health
- Influenza Virus Research Studies
- Viral Infections and Outbreaks Research
- Virology and Viral Diseases
- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- Leprosy Research and Treatment
- Escherichia coli research studies
- Viral Infections and Vectors
- Hepatitis Viruses Studies and Epidemiology
- Mycobacterium research and diagnosis
- Salmonella and Campylobacter epidemiology
- Hepatitis B Virus Studies
- Mosquito-borne diseases and control
- Clostridium difficile and Clostridium perfringens research
- Autopsy Techniques and Outcomes
- Vibrio bacteria research studies
- Emergency and Acute Care Studies
- Streptococcal Infections and Treatments
Centre Pour le Développement des Vaccins-Mali
2016-2025
University of Maryland, Baltimore
2013-2024
University of Maryland, College Park
2012-2023
Bordeaux Population Health
2022
Université Claude Bernard Lyon 1
2022
Institut Bergonié
2022
University of Sierra Leone
2022
French Clinical Research Infrastructure Network
2022
Centre Hospitalier Universitaire de Bordeaux
2022
Université Paris-Est Créteil
2022
Pneumonia is the leading cause of death among children younger than 5 years. In this study, we estimated causes pneumonia in young African and Asian children, using novel analytical methods applied to clinical microbiological findings.
Leprosy, a chronic human disease with potentially debilitating neurological consequences, results from infection Mycobacterium leprae. This unculturable pathogen has undergone extensive reductive evolution, half of its genome now occupied by pseudogenes. Using comparative genomics, we demonstrated that all extant cases leprosy are attributable to single clone whose dissemination worldwide can be retraced analysis very rare single-nucleotide polymorphisms. The seems have originated in Eastern...
Abstract Neisseria meningitidis is one of the leading causes bacterial meningitis globally and can also cause sepsis, pneumonia, other manifestations. In countries with high endemic rates, disease burden places an immense strain on public health system. The worldwide epidemiology invasive meningococcal (IMD) varies markedly by region over time. This review summarizes IMD in different identifies highest-incidence where routine preventive programs against would be most beneficial providing...
Background. Diarrhea is a leading cause of illness and death among children aged <5 years in developing countries. This paper describes the clinical epidemiological methods used to conduct Global Enteric Multicenter Study (GEMS), 3-year, prospective, age-stratified, case/control study estimate population-based burden, microbiologic etiology, adverse consequences acute moderate-to-severe diarrhea (MSD) censused population 0–59 months seeking care at health centers sub-Saharan Africa South...
Shigella case isolates from the Global Enteric Multicenter Study were serotyped to guide vaccine development. A quadrivalent that includes O antigens S. sonnei, flexneri 2a, 3a, and 6 should provide broad protection. Background. Shigella, a major diarrheal disease pathogen worldwide, is target of The (GEMS) investigated burden etiology moderate-to-severe in children aged <60 months matched controls without diarrhea during 3 years at 4 sites Africa Asia. was 1 most common pathogens across age...
Leprosy was endemic in Europe until the Middle Ages. Using DNA array capture, we have obtained genome sequences of Mycobacterium leprae from skeletons five medieval leprosy cases United Kingdom, Sweden, and Denmark. In one case, so well preserved that full de novo assembly ancient bacterial could be achieved through shotgun sequencing alone. The M. were compared with those 11 modern strains, representing diverse genotypes geographic origins. comparisons revealed remarkable genomic...
Background The importance of Cryptosporidium as a pediatric enteropathogen in developing countries is recognized. Methods Data from the Global Enteric Multicenter Study (GEMS), 3-year, 7-site, case-control study moderate-to-severe diarrhea (MSD) and GEMS-1A (1-year MSD less-severe [LSD]) were analyzed. Stools 12,110 3,174 LSD cases among children aged <60 months 21,527 randomly-selected controls matched by age, sex community immunoassay-tested for Cryptosporidium. Species subset...
Despite the heightened risk of serious influenza during infancy, vaccination is not recommended in infants younger than 6 months. We aimed to assess safety, immunogenicity, and efficacy maternal immunisation with trivalent inactivated vaccine for protection against a first episode laboratory-confirmed influenza.We did this prospective, active-controlled, observer-blind, randomised phase 4 trial at six referral centres community health Bamako, Mali. Third-trimester pregnant women (≥28 weeks'...
Diarrheal diseases remain a leading cause of illness and death among children younger than 5 years in low-income middle-income countries. The Global Enteric Multicenter Study (GEMS) has described the incidence, aetiology, sequelae medically attended moderate-to-severe diarrhoea (MSD) aged 0-59 months residing censused populations sub-Saharan Africa south Asia, where most child deaths occur. To further characterise this disease burden guide interventions, we extended study to include with...
The 2014 west African Zaire Ebola virus epidemic prompted worldwide partners to accelerate clinical development of replication-defective chimpanzee adenovirus 3 vector vaccine expressing glycoprotein (ChAd3-EBO-Z). We aimed investigate the safety, tolerability, and immunogenicity ChAd3-EBO-Z in Malian US adults, assess effect boosting Malians with modified vaccinia Ankara other filovirus antigens (MVA-BN-Filo).
The Global Enteric Multicenter Study (GEMS) was a 3-year case-control study that measured the burden, aetiology, and consequences of moderate-to-severe diarrhoea (MSD) in children aged 0-59 months. GEMS-1A, 12-month follow-on study, comprised two parallel studies, one assessing MSD other less-severe (LSD). In this report, we analyse risk death with each type specific pathogens associated fatal outcomes.GEMS prospective, age-stratified, matched done at seven sites Africa Asia. Children months...
Importance The number of deaths children younger than 5 years has been steadily decreasing worldwide, from more 17 million annual in the 1970s to an estimated 5.3 2019 (with 2.8 occurring those aged 1-59 months [53% all &amp;lt;5 years]). More detailed characterization childhood could inform interventions improve child survival. Objective To describe causes postneonatal across 7 mortality surveillance sentinel sites Africa and Asia. Design, Setting, Participants Child Health Mortality...
BackgroundKlebsiella pneumoniae is an important cause of nosocomial and community-acquired pneumonia sepsis in children, antibiotic-resistant K a growing public health threat. We aimed to characterise child mortality associated with this pathogen seven high-mortality settings.MethodsWe analysed Child Health Mortality Prevention Surveillance (CHAMPS) data on the causes deaths children younger than 5 years stillbirths sites located countries across sub-Saharan Africa (Ethiopia, Kenya, Mali,...
Background. Enteroaggregative Escherichia coli (EAEC) is a cause of epidemic and sporadic diarrhea, yet its role as an enteric pathogen not fully understood. Methods. We characterized 121 EAEC strains isolated in 2008 part case-control study moderate to severe acute diarrhea among children 0–59 months age Bamako, Mali. applied multiplex polymerase chain reaction comparative genome hybridization identify potential virulence factors the strains, coupled with classification regression tree...
The Pneumonia Etiology Research for Child Health (PERCH) project is a 7-country, standardized, comprehensive evaluation of the etiologic agents causing severe pneumonia in children from developing countries. During previous etiology studies, between one-quarter and one-third patients failed to yield an obvious etiology; PERCH will employ evaluate previously unavailable innovative, more sensitive diagnostic techniques. Innovative rigorous epidemiologic analytic methods be used establish...