Farah Naz Qamar
A5091049933- Salmonella and Campylobacter epidemiology
- Viral gastroenteritis research and epidemiology
- Vibrio bacteria research studies
- Antibiotic Resistance in Bacteria
- Child Nutrition and Water Access
- Hepatitis Viruses Studies and Epidemiology
- Immunodeficiency and Autoimmune Disorders
- Escherichia coli research studies
- Tuberculosis Research and Epidemiology
- Clostridium difficile and Clostridium perfringens research
- Antibiotic Use and Resistance
- Vaccine Coverage and Hesitancy
- Aquaculture disease management and microbiota
- Innovations in Medical Education
- Bacteriophages and microbial interactions
- Pneumonia and Respiratory Infections
- Long-Term Effects of COVID-19
- Antibiotics Pharmacokinetics and Efficacy
- Zoonotic diseases and public health
- COVID-19 Clinical Research Studies
- Neonatal and Maternal Infections
- SARS-CoV-2 and COVID-19 Research
- Blood disorders and treatments
- Food Security and Health in Diverse Populations
- Global Maternal and Child Health
Aga Khan University Hospital
2016-2025
Aga Khan University
2015-2025
Quaid-i-Azam University
2022
Aga Khan University Nairobi
2021
Queensland University of Technology
2021
University of Toronto
2020
University of the Punjab
2016
Antibiotic resistance is a major problem in Salmonella enterica serovar Typhi, the causative agent of typhoid. Multidrug-resistant (MDR) isolates are prevalent parts Asia and Africa often associated with dominant H58 haplotype. Reduced susceptibility to fluoroquinolones also widespread, sporadic cases third-generation cephalosporins or azithromycin have been reported. Here, we report first large-scale emergence spread novel S Typhi clone harboring three first-line drugs (chloramphenicol,...
The emergence of increasingly antimicrobial-resistant Salmonella enterica serovar Typhi (S Typhi) threatens to undermine effective treatment and control. Understanding where antimicrobial resistance in S is emerging spreading crucial towards formulating control strategies.In this genomic epidemiology study, we sequenced the genomes 3489 strains isolated from prospective enteric fever surveillance studies Nepal, Bangladesh, Pakistan, India (between 2014 2019), combined these with a global...
Antimicrobial resistance (AMR) is an urgent global health challenge and a critical threat to modern care. Quantifying its burden in the WHO Region of Americas has been elusive—despite region’s long history surveillance. This study provides comprehensive estimates AMR assess this growing threat. We estimated deaths disability-adjusted life-years (DALYs) attributable associated with for 23 bacterial pathogens 88 pathogen–drug combinations countries 2019. obtained data from mortality...
Extensively Drug-Resistant Typhoid More than 1000 cases of XDR Salmonella Typhi have been confirmed in Pakistan. Until recently, vaccines against typhoid had limited efficacy and durability immunogenicity, but an effective conjugate vaccine is now available to be used typhoid-control efforts.
Salmonella enterica serotype Typhi (S Typhi) is a major public health problem in low-income and middle-income countries. We aimed to investigate the effectiveness impact of typhoid conjugate vaccine Typbar-TCV against S among children an outbreak setting extensively drug-resistant (XDR) Pakistan.This cohort study was done from Feb 21, 2018, Dec 31, 2019. A census survey all households located Qasimabad Latifabad subdistricts Hyderabad, Pakistan, at baseline, 174 005 were registered census....
Precise enteric fever disease burden data are needed to inform prevention and control measures, including the use of newly available typhoid vaccines. We established Surveillance for Enteric Fever in Asia Project (SEAP) these strategies.
BackgroundThe incidence of enteric fever, an invasive bacterial infection caused by typhoidal Salmonellae (Salmonella enterica serovars Typhi and Paratyphi), is largely unknown in regions without blood culture surveillance. The aim this study was to evaluate whether new diagnostic serological markers for Salmonella can reliably estimate population-level incidence.MethodsWe collected longitudinal samples from patients with culture-confirmed fever enrolled surveillance studies Bangladesh,...
Enteric fever, a systemic infection caused by Salmonella enterica serovars Typhi and Paratyphi A, remains major cause of morbidity mortality in low-income middle-income countries. fever is preventable through the provision clean water adequate sanitation can be successfully treated with antibiotics. However, high levels antimicrobial resistance (AMR) compromise effectiveness treatment. We provide estimates prevalence AMR S A 75 endemic countries, including 30 locations without data.
Abstract Background Shigella is a leading cause of acute watery diarrhea, dysentery, and diarrhea-attributed linear growth faltering, precursor to stunting lifelong morbidity. Several promising vaccines are in development field efficacy trials will require consortium potential vaccine trial sites with up-to-date diarrhea incidence data. Methods The Enterics for Global Health (EFGH) surveillance study employ facility-based enrollment cases aged 6–35 months 3 follow-up establish rates document...
Shigella is a major cause of diarrhea in young children worldwide. Multiple vaccines targeting are development, and phase 3 clinical trials imminent to determine efficacy against shigellosis. The Enterics for Global Health (EFGH) surveillance study designed the incidence medically attended shigellosis 6- 35-month-old 7 resource-limited settings. Here, we describe microbiological methods used isolate identify Shigella. We developed standardized laboratory protocol isolation identification by...
The Aga Khan University clinical microbiology laboratory identified an outbreak of ceftriaxone-resistant Salmonella Typhi in Hyderabad, Pakistan, through antimicrobial resistance surveillance. An investigation was carried out to identify the risk factors and institute control measures. Here we report preliminary findings this investigation, using data collected from 30 November 2016 28 March 2017. design for a case-control study that included identification culture-proven S. cases, suspected...
Abstract Background Clinicians have limited therapeutic options for enteric as a result of increasing antimicrobial resistance, and therefore typhoid vaccination is recommended preventive measure. As part the Surveillance Enteric Fever in Asia Project (SEAP), we investigated extent measured burden resistance (AMR) among confirmed fever cases Bangladesh, Nepal, Pakistan. Methods From September 2016–September 2019, SEAP recruited study participants all age groups from its outpatient,...
The objective of Phase I the Surveillance for Enteric Fever in Asia Project (SEAP), a multiphase surveillance study characterizing burden disease South Asia, was to inform data collection prospective and capture clinical aspects disease.Through retrospective record review conducted at hospitals Bangladesh, India, Nepal, Pakistan, we examined laboratory records assess culture positivity rate Salmonella Typhi Paratyphi, age sex distribution, antimicrobial susceptability each country.Of all...
Introduction Salmonella Typhi is one of the leading health problems in Pakistan. With emergence extensively drug resistant (XDR) Typhi, treatment options are limited. Here we report clinical manifestations and response to patients with XDR Typhoid fever. The were treated either Meropenem or Azithromycin a combination both. Methods We reviewed records culture confirmed typhoid who visited Aga Khan University Hospital (AKUH), Karachi Secondary Care Hospital, Hyderabad from April 2017 June...
The COVID-19 pandemic has exposed weaknesses in disease surveillance nearly all countries. Early identification of cases and clusters for rapid containment was hampered by inadequate diagnostic capacity, insufficient contact tracing, fragmented data systems, incomplete insights public health responders, suboptimal governance these elements. Once SARS-CoV-2 became widespread, interventions to control community transmission were undermined weak national capacity integrate timely adjustment...