Алла Волоха
A5011490809- Immunodeficiency and Autoimmune Disorders
- HIV/AIDS Research and Interventions
- Hepatitis C virus research
- HIV Research and Treatment
- Hepatitis B Virus Studies
- Adolescent Sexual and Reproductive Health
- Kawasaki Disease and Coronary Complications
- Chronic Lymphocytic Leukemia Research
- Blood disorders and treatments
- HIV/AIDS drug development and treatment
- HIV, Drug Use, Sexual Risk
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- HIV-related health complications and treatments
- Immune responses and vaccinations
- Tuberculosis Research and Epidemiology
- Adolescent and Pediatric Healthcare
- Diabetes and associated disorders
- Pediatric health and respiratory diseases
- Blood groups and transfusion
- Pneumocystis jirovecii pneumonia detection and treatment
- Parvovirus B19 Infection Studies
- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- Herpesvirus Infections and Treatments
Riga East University Hospital
2025
Shupyk National Healthcare University of Ukraine
2015-2024
Institute of Pediatrics, Obstetrics, and Gynecology named after acad. O.M. Lukyanova of the National Academy of Medical Sciences of Ukraine
2022
Kyiv City Clinical Oncology Center
2016-2018
Kharkiv Medical Academy of Postgraduate Education
2004
Background Globally, the population of adolescents living with perinatally acquired HIV (APHs) continues to expand. In this study, we pooled data from observational pediatric cohorts and cohort networks, allowing comparisons in "real-life" settings across multiple regions. We describe geographic temporal characteristics mortality outcomes APHs regions, including South America Caribbean, North America, Europe, sub-Saharan Africa, Southeast Asia. Methods findings Through Collaborative...
Life-threatening “breakthrough” cases of critical COVID-19 are attributed to poor or waning antibody (Ab) response SARS-CoV-2 vaccines in individuals already at risk. Preexisting auto-Abs neutralizing type I IFNs underlie least 15% pneumonia unvaccinated individuals; their contribution hypoxemic breakthrough vaccinated people is unknown. We studied a cohort 48 (aged 20 86 years) who received two doses messenger RNA (mRNA) vaccine and developed infection with 2 weeks 4 months later. Ab levels...
Abstract Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome (WS) is a combined immunodeficiency caused by gain-of-function mutations in the C-X-C chemokine receptor type 4 ( CXCR4 ) gene. We characterize unique international cohort of 66 patients, including 57 (86%) cases previously unreported, with variable clinical phenotypes. Of 17 distinct genetic variants within our cohort, 11 were novel pathogenic affecting 15 individuals (23%). All affect same region impair...
Objectives: To estimate the probability of long-term nonprogression (LTNP) in absence antiretroviral treatment (ART) children with perinatally acquired HIV, and impact LTNP definitions on these estimates. Design: Analysis longitudinal routine care data (follow-up to 2016) collected through a collaboration cohorts HIV across Europe Thailand. Methods: was defined as reaching age 8 years without disease progression (defined an AIDS diagnosis or immunosuppression based WHO...
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Published estimates of mortality and progression to AIDS as children with HIV approach adulthood are limited. We describe rates risk factors for death AIDS-defining events in adolescents after initiation combination antiretroviral therapy (cART) 17 middle- high-income countries, including some Western Central Europe (W&CE), Eastern (Russia Ukraine), Thailand.Children perinatal aged <18 years initiating cART were followed until their 21st birthday, transfer adult care, death, loss follow-up,...
BackgroundAllergies have long been observed in Inborn Errors of Immunity (IEI) and might even be the first presentation resulting delayed diagnosis or misdiagnosis some cases. However, data on prevalence allergic diseases among IEI patients are limited contradictory.ObjectiveTo provide a worldwide view diseases, across broad spectrum IEI, their impact timely IEI.MethodsThis is study, conceived by World Allergy Organization (WAO) Committee. A questionnaire was developed pilot-tested sent via...
BackgroundIntegrase inhibitor (INSTI) with boosted darunavir (DRV/r), a regimen high-resistance barrier, avoiding NRTI toxicities, might be switching option in children living HIV (CLWHIV).MethodsSMILE is randomised non-inferiority trial evaluating safety and antiviral efficacy of once-daily INSTI + DRV/r vs. continuing on current standard-of-care (SOC) triple ART (2NRTI PI/NNRTI) virologically-suppressed CLWHIV aged 6–18 years. The primary outcome the proportion confirmed HIV-RNA ≥50...
Chronic hepatitis C (HCV) in women of childbearing age is a major public health concern with ∼15 million aged 15-49 years living HCV globally 2019. Evidence suggests pregnancy associated adverse and infant outcomes. This includes ∼6% risk infants acquiring vertically, this the leading cause children globally. However, few countries offer routine universal antenatal screening, direct-acting antivirals (DAAs) are not approved for pregnant or breastfeeding although small clinical trials...
<h2>Summary</h2><h3>Background</h3> Estimates of incidence switching to second-line antiretroviral therapy (ART) among children with HIV are necessary inform the need for paediatric formulations. We aimed quantify cumulative ART in an international cohort collaboration. <h3>Methods</h3> In this collaboration study, we pooled individual patient-level data younger than 18 years who initiated (two or more nucleoside reverse-transcriptase inhibitors [NRTI] plus a non-NRTI [NNRTI] boosted...
Background Weekends off antiretroviral therapy (ART) may help engage HIV-1-infected young people facing lifelong treatment. BREATHER showed short cycle (SCT; 5 days on, 2 ART) was non-inferior to continuous (CT) over 48 weeks. Planned follow-up extended 144 weeks, maintaining original randomisation. Methods an open-label, non-inferiority trial. Participants aged 8-24yrs with virological suppression on efavirenz-based first-line ART were randomised 1:1, stratified by age and...
Abstract Introduction Adolescents living with HIV are subject to multiple co‐morbidities, including growth retardation and immunodeficiency. We describe CD4 evolution during adolescence using data from the Collaborative Initiative for Paediatric Education Research (CIPHER) global project. Methods Data were collected between 1994 2015 11 CIPHER networks worldwide. perinatally acquired infection (APH) who initiated antiretroviral therapy (ART) before age 10 years, at least one height or count...
Background Ukraine has the second largest European HIV epidemic. This study aimed to describe stigma, demographic and social factors their association with anxiety among perinatally behaviourally-HIV-infected (PHIV; BHIV) young people in Kiev Odessa. Methods 104 PHIV 100 BHIV aged 13–25 years completed a confidential tablet-based survey. Survey tools included Hospital Anxiety Depression Scale (HADS) (anxiety sub-scale scores of 8–10 indicating mild ≥11 moderate/severe symptoms last 7 days),...
Over 3500 HIV-positive women give birth annually in Ukraine, a setting with high prevalence of sexually transmitted infections. Herpes simplex virus Type 2 (HSV-2) co-infection may increase HIV mother-to-child transmission (MTCT) risk. We explored factors associated HSV-2 seropositivity among and its impact on MTCT. Data 1513 enrolled the Ukraine European Collaborative Study from 2007 to 2012 were analysed. Poisson logistic regression models respectively fit investigate Median maternal age...
Introduction The J Project (JP) physician education and clinical research collaboration program was started in 2004 includes by now 32 countries mostly Eastern Central Europe (ECE). Until the end of 2021, 344 inborn errors immunity (IEI)-focused meetings were organized JP to raise awareness facilitate diagnosis treatment patients with IEI. Results In this study, meeting profiles major diagnostic parameters studied. center leaders reported patients’ data from 30 representing a total...
Introduction Nijmegen breakage syndrome (NBS) is an autosomal recessive disorder, characterized by microcephaly, immunodeficiency, and impaired DNA repair. NBS most prevalent among Slavic populations, including Ukraine. Our study aimed to comprehensively assess the prevalence, diagnosis, clinical data, immunological parameters, treatment of patients in Methods We conducted a retrospective review that included 84 from different regions Ukraine who were diagnosed 1999-2023. Data Ukrainian...
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), also known as autoimmune polyglandular syndrome type 1 (APS-1) is a rare autosomal recessive inborn error of immunity (IEI), which accompanied by immune dysregulation. Hypoparathyroidism, adrenocortical failure and candidiasis are its typical manifestations. Here we report about recurrent COVID-19 in 3-year-old boy with APECED, who developed retinopathy macular atrophy hepatitis after the first episode SARS-CoV-2...