A5046051508- HIV Research and Treatment
- HIV-related health complications and treatments
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Gestational Diabetes Research and Management
- Rabies epidemiology and control
- Chronic Lymphocytic Leukemia Research
- Maternal and fetal healthcare
- Genetics and Physical Performance
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Effects and risks of endocrine disrupting chemicals
- Data-Driven Disease Surveillance
- Obesity, Physical Activity, Diet
- Noise Effects and Management
- Ectopic Pregnancy Diagnosis and Management
- Bacillus and Francisella bacterial research
- Breastfeeding Practices and Influences
- Pneumocystis jirovecii pneumonia detection and treatment
- Sexual Differentiation and Disorders
- Toxic Organic Pollutants Impact
- Birth, Development, and Health
- Folate and B Vitamins Research
- Cleft Lip and Palate Research
- Cytomegalovirus and herpesvirus research
- Pregnancy and Medication Impact
Community Initiatives
2023
Duquesne University
2023
Florida Department of Health
1986-2014
Harvard University
2013
Harvard University Press
2004
Lexington Clinic
1993
Maternal cigarette smoking is a suspected cause of oral clefts, although this association has not been firmly established. We used case-crossover, case-time-control, and bidirectional case-crossover designs to supplement findings from case-control study maternal clefts among offspring in large birth registry.Data are the Swedish Medical Birth Registry. From 1983 through 1997 there were 678 recorded cases cleft palate 1175 lip with or without palate. status was ascertained early pregnancy....
<h2>Summary</h2><h3>Background</h3> Estimates of incidence switching to second-line antiretroviral therapy (ART) among children with HIV are necessary inform the need for paediatric formulations. We aimed quantify cumulative ART in an international cohort collaboration. <h3>Methods</h3> In this collaboration study, we pooled individual patient-level data younger than 18 years who initiated (two or more nucleoside reverse-transcriptase inhibitors [NRTI] plus a non-NRTI [NNRTI] boosted...
We characterized physical growth and sexual maturation in 2,579 boys, ages 10 through 16.99 years, residing Chapaevsk, Russia order to establish region-specific reference data. Age-specific norms were established for height, weight, BMI, compared US data by z-score analysis, while mean heights weights age published national Russian Compared height was slightly lower (overall -0.18) at all except the oldest (16-16.99 yr), weight BMI moderately -0.52 -0.61, respectively). Chapaevsk boys...
This article describes and contrasts the public health response to two human rabies cases: one organ recipient diagnosed within days of symptom onset transplant donor who was 18 months post-symptom onset. In an organ-transplant-related case in 2013, investigations were conducted by multiple agencies. Persons with potential exposure infectious patient materials assessed for virus exposure. An investigation determine source donor's infection. Over 100 persons from more than 20 agencies spent...
7‐11 November 2010, Tenth International Congress on Drug Therapy in HIV Infection, Glasgow, UK
Because of concerns about safety and expense associated with continuous subcutaneous insulin infusion (CSII), all people who had used CSII as July 1982 were identified. Annual follow-up has resulted in data for up to 61 mo. Of the 92 nonpregnant registrees, 31 less than 20 yr old, 36 20-29, 25 30 or older. Two deaths occurred 1780 person-months pump use. The cumulative proportion on (CPOP) actuarial continuance was 11%. There no significant difference between sexes ages men, but despite...
At week 96 vs. 48, there were few TMC278 doserelated effects, and no change in types nor notable increase incidence of AEs. All rashes grade 1 or 2, except one case 3 rash (TMC278 75 mg arm, dapsone-related). Rashes resolved with continued dosing (median duration: all 17 EFV 15 days). Incidences 4 nervous system AEs (no discontinuations; TMC278: 0.7% EFV: 1.1%) psychiatric (1.8% low. Psychiatric led to discontinuation 0.4% 2.2% patients. Conclusion Over weeks, demonstrated a high, sustained...
Background: Few human studies have evaluated the impact of childhood exposure to organochlorine pesticides (OCP) on sexual maturity, especially in boys. Aims: To evaluate association serum OCP concentrations [hexachlorobenzene (HCB), ?-hexachlorocyclohexane (?-HCH), and p,p-dichlorodiphenyldichloroethylene (p,p'-DDE)] with maturity among boys Chapaevsk, Russia, a town environmental contamination from compounds. Methods: 499 were recruited at ages 8-9 years 2003-2005 Russia followed...
Air pollution is linked to increased risk for health problems, with a disproportionate impact on those living in industrial communities. Although many air quality studies have been conducted through the lens of (in)equity, relatively few include perspective residents as part program design. This study focused one community and aimed understand residents' knowledge experience related pollution, its health, thoughts intervention strategies, develop community-led strategy decrease exposure....
Abstract Background The prevalence of congenital cytomegalovirus infection (cCMV) at birth is 0.5%–1% in the United States. Most cCMV newborns are asymptomatic with 10%–15% subsequently developing sequelae, such as hearing loss. Higher (2.5%–11.4%) reported infants born to HIV-infected women, associated maternal immune suppression and lack antiretroviral therapy (ART), few studies addressing neurodevelopmental (ND) outcomes their offspring. We report a cohort HIV-exposed, uninfected (HEU)...
Abstract Background With improved treatment, women living with HIV (WLHIV) are increasingly becoming pregnant. Studies have shown suboptimal viral suppression following pregnancy. In addition, protease inhibitors (PI) been associated preterm birth (PTB). Methods We studied WLHIV at least 2 live births while on the PHACS SMARTT study. first compared CD4 counts and loads (VL) between second pregnancies using Wilcoxon rank-sum tests. then examined trends in these measures over all reported...
SAB3-PD-05 Introduction: In Chapaevsk, Russia, where there is high environmental exposure to polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and biphenyls (PCBs), we assessed the dietary contribution of locally produced foods serum levels these compounds in boys. Methods: Our study sample included 123 boys 8 9 years age enrolled 2003. The boys’ initial visit physical examinations, blood sampling, completion semiquantitative food frequency questionnaires by parents or...