A5010795289- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Adolescent Sexual and Reproductive Health
- HIV-related health complications and treatments
- Poverty, Education, and Child Welfare
- Global Maternal and Child Health
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS Impact and Responses
- HIV, Drug Use, Sexual Risk
- Adolescent and Pediatric Healthcare
- Virus-based gene therapy research
- Child Nutrition and Water Access
- Poxvirus research and outbreaks
- Syphilis Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Pharmaceutical studies and practices
- Gestational Diabetes Research and Management
- Pharmacological Effects and Toxicity Studies
- Hepatitis B Virus Studies
- Immunotherapy and Immune Responses
- Child and Adolescent Health
- SARS-CoV-2 detection and testing
- Global Public Health Policies and Epidemiology
- Vaccine Coverage and Hesitancy
New York University
1997-2024
United Nations Children's Fund
2018-2024
University School
2024
Zero to Three
2015-2023
World Health Organization
2012-2019
University of Maryland, Baltimore
2017
Clinton Health Access Initiative
2010-2015
Clinton Foundation
2010
Office of Infectious Diseases
2005
Columbia University
2004
Stakeholders agree that supporting high-quality diagnostics is essential if we are to continue make strides in the fight against human immunodeficiency virus (HIV) and tuberculosis. Despite need strengthen existing laboratory infrastructure, which includes expanding developing new laboratories, there clear diagnostic needs where conventional support insufficient. Regarding HIV, rapid point-of-care (POC) testing for initial HIV diagnosis has been successful, but several remain. For...
Melanie Taylor and colleagues discuss progress towards eliminating vertical transmission of HIV syphilis.
Triple elimination is an initiative supporting the of mother-to-child transmission three diseases - human immunodeficiency virus (HIV) infection, syphilis and hepatitis B. Significant progress towards triple has been made in some regions, but slow sub-Saharan Africa, region with highest burden these diseases. The shared features diseases, including their epidemiology, disease interactions core interventions for tackling them, enable integrated health-systems approach transmission. Current...
In recent years, there has been significant investment from both the private and public sectors in development of diagnostic technologies to meet need for human immunodeficiency virus (HIV) tuberculosis testing low-resource settings. Future investments should ensure that most appropriate are adopted settings where they will have a sustainable impact. Achieving these aims requires involvement many stakeholders, as their needs, operational constraints, priorities often distinct. Here, we...
Landon Myer and colleagues discuss viral load monitoring for pregnant HIV-positive women those breastfeeding; ART treatments can suppress are key to preventing transmission the child.
Objective: To determine the long-term immunologic and virologic effects of highly active antiretroviral therapy (HAART) in children with AIDS. Design: A prospective observational study. Setting: Two pediatric HIV clinics. Participants: Twenty-five protease-inhibitor naive HIV-infected (aged 2-18 years) advanced disease (CD4≤6%). Intervention: HAART (one protease inhibitor one or more nucleoside analogs). Diphtheria tetanus immunization six patients after 18 months therapy. Main outcome...
Introduction Key populations, including female sex workers (FSW), people who inject drugs (PWID), and in serodiscordant partnerships, experience higher HIV incidence compared to the general population. Maternal retesting, particularly during late pregnancy, helps detect new infections prevent vertical transmission, but optimal testing schedules among key populations are unknown. Methods We used a Markov model estimate health economic impacts of maternal retesting on transmission outcomes FSW...
Few studies have investigated the efficacy of antiretroviral therapy among HIV-infected children in resource-poor settings. This observational, retrospective analysis describes clinical, immunologic, and virologic effects highly active treatment-naive, Mombasa, Kenya. In keeping with a public health approach, all were treated by using simplified, nationally approved, triple-drug regimen.Clinical data stored plasma samples from 29 who followed prospectively between April 2003 October 2004...
The International Maternal, Pediatric, and Adolescent Clinical Trials P1060 trial demonstrated superior outcomes for HIV-infected children less than 3 years old initiating antiretroviral therapy (ART) with lopinavir/ritonavir compared to nevirapine, but is four-fold costlier.We used the Cost-Effectiveness of Preventing AIDS Complications (CEPAC)-Pediatric model, published data, project under three strategies: no ART; first-line nevirapine (with second-line lopinavir/ritonavir); (second-line...
Great gains were achieved with the introduction of United Nations' Millennium Development Goals, including improved child survival. Transition to Sustainable Goals (SDGs) focused on surviving, thriving and transforming, representing an important shift a broader public health goal, achievement which holds promise longer-term individual societal benefits. A similar is needed respect outcomes for infants born women living HIV (WLHIV). Programming prevent vertical transmission has been...