A5045698591- Syphilis Diagnosis and Treatment
- Reproductive tract infections research
- Adolescent Sexual and Reproductive Health
- HIV/AIDS Research and Interventions
- Herpesvirus Infections and Treatments
- Sex work and related issues
- HIV/AIDS Impact and Responses
- HIV, Drug Use, Sexual Risk
- Reproductive Health and Contraception
- Global Maternal and Child Health
- COVID-19 and Mental Health
- Bacterial Infections and Vaccines
- Data-Driven Disease Surveillance
- Cytomegalovirus and herpesvirus research
- Parvovirus B19 Infection Studies
- SARS-CoV-2 detection and testing
- Female Genital Mutilation/Cutting Issues
- COVID-19 Clinical Research Studies
- Global Public Health Policies and Epidemiology
- Prenatal Screening and Diagnostics
- HIV/AIDS oral health manifestations
- Vector-borne infectious diseases
- Genital Health and Disease
- Drug-Induced Adverse Reactions
- Blood groups and transfusion
National Institute of Allergy and Infectious Diseases
2019-2024
National Institutes of Health
2021-2024
Libin Cardiovascular Institute of Alberta
2022
University of Calgary
2022
Emory University
2022
Centers for Disease Control and Prevention
2006-2020
University of Nebraska at Omaha
2020
John Wiley & Sons (United Kingdom)
2020
World Health Organization
2010-2018
Cambodia National Malaria Center
2018
To generate estimates of the global prevalence and incidence urogenital infection with chlamydia, gonorrhoea, trichomoniasis syphilis in women men, aged 15-49 years, 2016.For gonorrhoea trichomoniasis, we systematically searched for studies conducted between 2009 2016 reporting prevalence. We also consulted regional experts. estimates, used Bayesian meta-analysis. For syphilis, aggregated national generated by using Spectrum-STI.For and/or 130 were eligible. Spectrum-STI database contained...
Background Herpes simplex virus type 1 (HSV-1) commonly causes orolabial ulcers, while HSV-2 genital ulcers. However, HSV-1 is an increasing cause of infection. Previously, the World Health Organization estimated global burden for 2003 and 2012. The has not been estimated. Methods We fitted a constant-incidence model to pooled prevalence data from literature searches 6 regions used 2012 population derive numbers 0-49-year-olds with prevalent incident To estimate HSV-1, we applied values...
Background Herpes simplex virus type 2 (HSV-2) infection causes significant disease globally. Adolescent and adult may present as painful genital ulcers. Neonatal has high morbidity mortality. Additionally, HSV-2 likely contributes substantially to the spread of HIV infection. The global burden was last estimated for 2003. Here we new estimates 2012 prevalent (existing) incident (new) among females males aged 15–49 years, using updated methodology adjust test performance estimate by World...
The World Health Organization initiative to eliminate mother-to-child transmission of syphilis aims for ≥ 90% pregnant women be tested and receive treatment by 2015. We calculated global regional estimates in pregnancy associated adverse outcomes 2008, as well antenatal care (ANC) coverage with syphilis.Estimates were based upon a health service delivery model. National seropositivity data from 97 193 countries ANC 147 obtained databases. Proportions effectiveness screening published...
Background In 2007 the World Health Organization (WHO) launched global initiative to eliminate mother-to-child transmission of syphilis (congenital syphilis, or CS). To assess progress towards goal <50 CS cases per 100,000 live births, we generated regional and estimates maternal congenital for 2016 updated 2012 estimates. Methods Maternal were using Spectrum-STI model, fitted sentinel surveys routine testing pregnant women during antenatal care (ANC) other representative population data....
In 2007, WHO launched a global initiative for the elimination of mother-to-child transmission syphilis (congenital syphilis). An important aspect is strengthening surveillance to monitor progress towards elimination. 2008, using health systems model with country data inputs, estimated that 1·4 million maternal infections caused 520 000 adverse pregnancy outcomes. To assess progress, we updated 2008 estimates and 2012 prevalence cases congenital syphilis.We used approved by Child Health...
BackgroundNeonatal herpes is a rare but potentially devastating condition with an estimated 60% fatality rate without treatment. Transmission usually occurs during delivery from mothers simplex virus type 1 (HSV-1) or 2 (HSV-2) genital infection. However, the global burden has never been quantified to our knowledge. We developed novel methodology for estimation and present first WHO regional estimates of annual number neonatal cases 2010–15.MethodsWe applied previous HSV-1 HSV-2 prevalence...
Background. Ceftriaxone is the foundation of currently recommended gonorrhea treatment. There an urgent need for backup treatment options patients with cephalosporin allergy or infections due to suspected cephalosporin-resistant Neisseria gonorrhoeae. We evaluated efficacy and tolerability 2 combinations existing noncephalosporin antimicrobials urogenital gonorrhea. Methods. conducted a randomized, multisite, open-label, noncomparative trial in 5 outpatient sexually transmitted disease...
Background Syphilis in pregnancy imposes a significant global health and economic burden. More than half of cases result serious adverse events, including infant mortality infection. The annual burden from mother-to-child transmission (MTCT) syphilis is estimated at 3.6 million disability-adjusted life years (DALYs) $309 medical costs. screening treatment simple, effective, affordable, yet, worldwide, most pregnant women do not receive these services. We assessed cost-effectiveness...
Azithromycin and doxycycline are both recommended treatments for rectal Chlamydia trachomatis (CT) infection, but observational studies suggest that may be more effective.This randomized, double-blind, placebo-controlled trial compared azithromycin (single 1-g dose) versus (100 mg twice daily 7 days) the treatment of CT in men who have sex with (MSM) Seattle Boston. Participants were enrolled after a diagnosis clinical care underwent repeated collection swabs nucleic acid amplification...
Congenital syphilis is the oldest recognized congenital infection, and continues to account for extensive global perinatal morbidity mortality today. Serious adverse pregnancy outcomes caused by maternal infection are prevented with screening early in prompt treatment of women testing positive. Intramuscular penicillin, an inexpensive antibiotic on essential medicine list nations all over world, effectively cures prevents syphilis. In fact, at a cost $11-15 per disability adjusted life year...
Melanie Taylor and colleagues discuss progress towards eliminating vertical transmission of HIV syphilis.
Antimicrobial resistance in Mycoplasma genitalium (MG), a cause of urethritis, is growing concern. Yet little known about the geographic distribution MG United States or its associated clinical outcomes. We evaluated frequency among men with mutations, and posttreatment symptom persistence.We enrolled presenting urethritis symptoms to 6 US sexually transmitted disease (STD) clinics during June 2017-July 2018; were eligible for follow-up contact and, if they had persistent MG, chart review....