A5069892567- Reproductive tract infections research
- Bacterial Infections and Vaccines
- Syphilis Diagnosis and Treatment
- Adolescent Sexual and Reproductive Health
- Pneumonia and Respiratory Infections
- Urinary Tract Infections Management
- Reproductive Health and Contraception
- Microbial infections and disease research
- Streptococcal Infections and Treatments
- Blood groups and transfusion
- Cervical Cancer and HPV Research
- Genital Health and Disease
- Herpesvirus Infections and Treatments
- Virology and Viral Diseases
- Bacterial Identification and Susceptibility Testing
- Clostridium difficile and Clostridium perfringens research
- HIV, Drug Use, Sexual Risk
- Gut microbiota and health
- Infective Endocarditis Diagnosis and Management
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Plant and fungal interactions
- HIV, TB, and STIs Epidemiology
- HIV/AIDS Research and Interventions
- Sex work and related issues
University College London
2022-2025
Örebro University Hospital
2015-2025
Örebro University
2016-2025
The London College
2022
Green Cross (South Korea)
2019
Yonsei University
2019
Bristol-Myers Squibb (South Korea)
2019
Weatherford College
2015
World Health Organization - Pakistan
2013-2014
Czech Academy of Sciences, Institute of Microbiology
2004-2010
To generate estimates of the global prevalence and incidence urogenital infection with chlamydia, gonorrhoea, trichomoniasis syphilis in women men, aged 15-49 years, 2016.For gonorrhoea trichomoniasis, we systematically searched for studies conducted between 2009 2016 reporting prevalence. We also consulted regional experts. estimates, used Bayesian meta-analysis. For syphilis, aggregated national generated by using Spectrum-STI.For and/or 130 were eligible. Spectrum-STI database contained...
ABSTRACT Recently, the first Neisseria gonorrhoeae strain (H041) that is highly resistant to extended-spectrum cephalosporin (ESC) ceftriaxone, last remaining option for empirical first-line treatment, was isolated. We performed a detailed characterization of H041, phenotypically and genetically, confirm finding, examine its antimicrobial resistance (AMR), elucidate mechanisms. H041 examined using seven species-confirmatory tests, antibiograms (30 antimicrobials), porB sequencing, N....
ABSTRACT Recently, the first Neisseria gonorrhoeae strain (H041) highly resistant to expanded-spectrum cephalosporins (ESCs) ceftriaxone and cefixime, which are last remaining options for first-line gonorrhea treatment, was isolated in Japan. Here, we confirm characterize a second (F89) with high-level cefixime resistance France most likely caused treatment failure cefixime. F89 examined using six species-confirmatory tests, antibiograms (33 antimicrobials), porB sequencing, N. multiantigen...
Antimicrobial resistance (AMR) in Neisseria gonorrhoeae seriously compromises the management and control of gonorrhea.• In vitro clinical N. to extended-spectrum cephalosporins (ESCs), last-line treatment for gonorrhea, have been reported from many, particularly well-resourced, settings globally.• The World Health Organization (WHO) Global Gonococcal Surveillance Programme (GASP) is key monitoring AMR trends, identifying emerging AMR, informing regular refinements guidelines public health...
Gonorrhoea is a major public health concern globally. Of particularly grave that resistance to the extended-spectrum cephalosporins has emerged during most recent years. This guideline provides recommendations regarding diagnosis and treatment of gonorrhoea in Europe. Compared outdated 2009 European guideline, this 2012 up-to-date guidance on, broader indications for testing gonorrhoea; introduction dual antimicrobial therapy (ceftriaxone 500 mg azithromycin 2 g) uncomplicated when...
Syphilis remains a major public health problem in Europe (both Eastern since the 1990's and Western re-emergence of disease late 1990's-early 2000's).This guideline is an update IUSTI: 2008 European on management syphilis produced by Guideline Editorial Board (http://www.iusti.org/regions/Europe/pdf/2013/Editorial_Board.pdf) EDF Committee.It provides recommendations concerning diagnosis Europe. Major advances include (1) broader use PCR, immunohistochemistry, subtyping etiological agent...
Chlamydia trachomatis infections, which most frequently are asymptomatic, major public health concerns globally. The 2015 European C. guideline provides: up-to-date guidance regarding broader indications for testing and treatment of infections; a clearer recommendation using exclusively-validated nucleic acid amplification tests diagnosis; advice on (repeated) testing; the increased to reduce incidence pelvic inflammatory disease prevent exposure infection; recommendations identify, verify...
We describe a gonorrhoea case with combined high-level azithromycin resistance and ceftriaxone resistance. In February 2018, heterosexual male was diagnosed in the United Kingdom following sexual intercourse locally resident female Thailand failed treatment plus doxycycline subsequently spectinomycin. Resistance arose from two mechanisms combining for first time genetic background similar to commonly circulating strain. Urgent action is essential prevent further spread.
Gonorrhoea and MDR Neisseria gonorrhoeae remain public health concerns globally. Enhanced, quality-assured, gonococcal antimicrobial resistance (AMR) surveillance is essential worldwide. The WHO global Gonococcal Antimicrobial Surveillance Programme (GASP) was relaunched in 2009. We describe the phenotypic, genetic reference genome characteristics of 2016 strains intended for quality assurance GASP, other GASPs, diagnostics research
Abstract The 2020 edition of the European guideline on management syphilis is an update 2014 edition. Main modifications and updates include: ongoing epidemics early in Europe, particularly men who have sex with (MSM) development dual treponemal non‐treponemal point‐of‐care (POC) tests progress test (NTT) automatization regular episodic shortage benzathine penicillin G (BPG) some countries exclusion azithromycin as alternative treatment at any stage pre‐exposure or immediate post‐exposure...
Background and Objective Bacterial vaginosis (BV) is the most common vaginal disorder, characterized by depletion of normal lactobacillus-dominant microbiota overgrowth commensal anaerobic bacteria. This study aimed to investigate composition in women reproductive age (healthy with BV), view developing molecular criteria for BV diagnosis. Materials Methods Vaginal samples from 163 (79 control, 73 11 intermediate (Lactobacillary grade II flora) cases) were analyzed using 454 pyrosequencing...
Traditional methods for molecular epidemiology of Neisseria gonorrhoeae are suboptimal. Whole-genome sequencing (WGS) offers ideal resolution to describe population dynamics and predict infer transmission antimicrobial resistance, can enhance infection control through linkage with epidemiological data. We used WGS, in conjunction linked phenotypic data, the gonococcal 20 European countries. aimed detail changes resistance levels (and reasons these changes) strain distribution (with a focus...