Julio A. Vázquez
A5032717221- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Reproductive tract infections research
- Infective Endocarditis Diagnosis and Management
- Virology and Viral Diseases
- Antibiotic Resistance in Bacteria
- Respiratory viral infections research
- Microbial infections and disease research
- Syphilis Diagnosis and Treatment
- Listeria monocytogenes in Food Safety
- Streptococcal Infections and Treatments
- Influenza Virus Research Studies
- Tracheal and airway disorders
- Genomics and Chromatin Dynamics
- Amoebic Infections and Treatments
- Microtubule and mitosis dynamics
- Pneumocystis jirovecii pneumonia detection and treatment
- Ubiquitin and proteasome pathways
- Neonatal and Maternal Infections
- Cystic Fibrosis Research Advances
- Antibiotics Pharmacokinetics and Efficacy
- Genomics and Phylogenetic Studies
- Radiopharmaceutical Chemistry and Applications
- Actinomycetales infections and treatment
- Essential Oils and Antimicrobial Activity
Instituto de Salud Carlos III
2015-2024
Hospital General Universitario Gregorio Marañón
2024
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2024
University of Cuenca
2023
Centro Nacional de Microbiologia
2007-2021
Centro Nacional de Epidemiología
1990-2019
Queensland University of Technology
2015
Universidad Rey Juan Carlos
2013-2014
Faculdade de Ciências Médicas da Santa Casa de São Paulo
2013
Pfizer (United States)
2013
Traditional methods for molecular epidemiology of Neisseria gonorrhoeae are suboptimal. Whole-genome sequencing (WGS) offers ideal resolution to describe population dynamics and predict infer transmission antimicrobial resistance, can enhance infection control through linkage with epidemiological data. We used WGS, in conjunction linked phenotypic data, the gonococcal 20 European countries. aimed detail changes resistance levels (and reasons these changes) strain distribution (with a focus...
A rabbit endocarditis model was utilized to evaluate the virulence conferred by conjugative plasmid pAD1 with following strains: Enterococcus faecalis plasmid-free FA2-2 and containing plasmids (hemolysin aggregation substance positive), pAM9058 (insertional inactivation of hemolysin), pAM944 or pAM947 substance). All isolates were similar in ability produce endocarditis. Mean vegetation weight greater animals inoculated strains that produced (P < 0.01). Mortality significantly increased...
ABSTRACT This study is a first step in the development of multilocus sequence typing (MLST) method for Listeria monocytogenes. Nine housekeeping genes were analyzed set 62 strains isolated from different sources and geographic locations Spain. These previously characterized by pulsed-field gel electrophoresis (PFGE). Because low diversity, two loci discarded study. The analysis seven remaining showed 29 allelic combinations, with 22 them represented only one strain. results this generally...
The Meningococcal Antigen Typing System (MATS) was developed to identify meningococcus group B strains with a high likelihood of being covered by the 4CMenB vaccine, but is limited requirement for viable isolates from culture-confirmed cases. We examined if antigen genotyping could complement MATS in predicting strain coverage vaccine. From panel 3912 MATS-typed invasive meningococcal disease collected England and Wales 2007–2008, 2014–2015 2015–2016, 16 other countries 2000–2015, 3481 were...
Background The total incidence of invasive meningococcal disease (IMD) in Europe has been declining recent years; however, a rising due to serogroup W (MenW), predominantly sequence type 11 (ST-11), clonal complex (cc11), was reported some European countries. Aim aim this study compile the most laboratory surveillance data on MenW IMD from several countries assess trends Europe. Methods In observational, retrospective study, collected 2013–17 by national reference laboratories and units 13...
BackgroundGenomic surveillance using quality-assured whole-genome sequencing (WGS) together with epidemiological and antimicrobial resistance (AMR) data is essential to characterise the circulating Neisseria gonorrhoeae lineages their association patient groups (defined by demographic factors). In 2013, European gonococcal population was characterised genomically for first time. We describe in 2018 identify emerging or vanishing associated AMR characteristics of patients, elucidate recent...
In September 2015, the four-component, protein-based meningococcal serogroup B vaccine (4CMenB; Bexsero) became available for private purchase in Spain.We conducted a nationwide matched case-control study to assess effectiveness of 4CMenB preventing invasive disease children. The included all laboratory-confirmed cases children younger than 60 months age between October 5, and 6, 2019, Spain. Each case patient was with four controls according date birth province. vaccination status patients...
BackgroundRegular quality-assured whole-genome sequencing linked to antimicrobial resistance (AMR) and patient metadata is imperative elucidate the shifting gonorrhoea epidemiology, both nationally internationally. We aimed examine gonococcal population in European Economic Area (EEA) 2020, emerging disappearing lineages associated with AMR metadata, compare 2013 2018 data, explain changes epidemiology.MethodsIn this retrospective genomic surveillance study, we analysed consecutive isolates...
Miklos Gaszner, Julio Vazquez, and Paul Schedl Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 USA
Clinical isolates of Neisseria meningitidis with reduced susceptibility to penicillin G (intermediate isolates, Pen(I)) harbor alterations in the penA gene encoding binding protein 2 (PBP2). A 402-bp DNA fragment 3' half was sequenced from a collection 1,670 meningococcal clinical 22 countries that spanned 60 years. Phenotyping, genotyping, and determination MICs were also performed. total 139 different alleles detected 38 highly related, clustered together maximum-likelihood analysis...
SUMMARY Meningococcal serogroup W strains have been emerging throughout the current century with most of isolates belonging to sequence type (ST11)/electrophoretic (ET37) clonal complex (ST11/E37 CC), particularly since international outbreak following Hajj 2000. That appears triggered off that trend, contributing spread ST11/ET37 CC globally; however, local could be also responsible for increases in percentage and/or incidence rates this some countries. More recently, unexpected and rate...
ABSTRACT Bivalent rLP2086 (Trumenba), a vaccine for prevention of Neisseria meningitidis serogroup B (NmB) disease, was licensed use in adolescents and young adults after it demonstrated that elicits antibodies initiate complement-mediated killing invasive NmB isolates serum bactericidal assay with human complement (hSBA). The consists two factor H binding proteins (fHBPs) representing divergent subfamilies to ensure broad coverage. Although is the surrogate efficacy, an hSBA not suitable...