A5045328465- Reproductive tract infections research
- Adolescent Sexual and Reproductive Health
- Syphilis Diagnosis and Treatment
- HIV/AIDS Research and Interventions
- Cervical Cancer and HPV Research
- Sex work and related issues
- Bacterial Infections and Vaccines
- Reproductive Health and Contraception
- HIV, Drug Use, Sexual Risk
- Genital Health and Disease
- Wound Healing and Treatments
- Herpesvirus Infections and Treatments
- Urinary Tract Infections Management
- Diagnosis and Treatment of Venous Diseases
- HIV Research and Treatment
- Bacterial Identification and Susceptibility Testing
- Surgical site infection prevention
- Antimicrobial Resistance in Staphylococcus
- Homelessness and Social Issues
- Urological Disorders and Treatments
- LGBTQ Health, Identity, and Policy
- Streptococcal Infections and Treatments
- Molecular Biology Techniques and Applications
- Clostridium difficile and Clostridium perfringens research
- Food Security and Health in Diverse Populations
Johns Hopkins Medicine
2014-2024
Johns Hopkins University
2014-2024
Johns Hopkins Bayview Medical Center
2011-2021
Public Health Foundation
2021
Baltimore City Health Department
1995-2020
John Wiley & Sons (United States)
2018
Hudson Institute
2018
University of Baltimore
1991-2017
Engineering Associates (United States)
2017
University of Maryland, Baltimore
2000-2013
These guidelines for the treatment of persons who have or are at risk sexually transmitted infections (STIs) were updated by CDC after consultation with professionals knowledgeable in field STIs met Atlanta, Georgia, June 11-14, 2019. The information this report updates 2015 guidelines. discuss 1) recommendations Neisseria gonorrhoeae, Chlamydia trachomatis, and Trichomonas vaginalis; 2) addition metronidazole to recommended regimen pelvic inflammatory disease; 3) alternative options...
Background. We sought to describe the temporal relationship between vaginal microbiota and human papillomavirus (HPV) detection.
Gonorrhea is the second most commonly reported notifiable disease in United States; 350,062 gonorrhea cases were 2014. Sexually transmitted infections caused by Neisseria gonorrhoeae are a cause of pelvic inflammatory women, which can lead to serious reproductive complications including tubal infertility, ectopic pregnancy, and chronic pain. Prevention sequelae transmission sexual partners relies largely on prompt detection effective antimicrobial treatment. However, treatment has been...
Studies of sexual behavior and interventions designed to reduce human immunodeficiency virus risk usually depend on self-report. Validation self-reported condom use measures has not been previously reported in an urban population at high for sexually transmitted diseases virus.A prospective cohort study was performed subjects recruited from disease clinics Baltimore. At enrollment, a questionnaire administered that assessed factors history, used retrospective calendar assess events over the...
Context.-Adolescents are at highest risk for infection with Chlamydia trachomatis, an important preventable cause of pelvic inflammatory disease and subse- quent tubal factor infertility in US women.Current guidelines delivery adolescent primary care services recommend yearly chlamydia screening those females considered to be risk.Objectives.-To describe the epidemiology prevalent incident among assess appropriate interval define factors that would identify target...
<b>Background:</b> Audio computer assisted self interview (ACASI) may minimise social desirability bias in the ascertainment of sensitive behaviours. The aim this study was to describe difference reporting risk behaviour ACASI compared a face (FFI) among public sexually transmitted diseases (STD) clinic attendees. <b>Study design:</b> Randomly selected patients attending STD Baltimore, Maryland, sequentially took an formatted assessment followed by FFI conducted single clinician, with both...
The prevalence of antibodies to hepatitis C virus (anti-HCV), the behavioral and laboratory-derived risk factors for anti-HCV, quantity homology HCV RNA were assessed among 1039 non-injection drug-using sexually transmitted disease (STD) patients representing 309 sex partnerships. Thirty-seven (7%) 555 males 19 (4%) 484 females had anti-HCV. In logistic regression analyses, associated with anti-HCV included age (P < .001), greater numbers lifetime partners = .023), human immunodeficiency...
Bacterial colonization is hypothesized to play a pathogenic role in the non-healing state of chronic wounds. We characterized wound bacteria from cohort patients using 16S rRNA gene-based pyrosequencing approach and assessed impact diabetes antibiotics on microbiota.We prospectively enrolled 24 at referral center Baltimore, MD; sampled patients' wounds by curette; cultured samples under aerobic anaerobic conditions; pyrosequenced V3 hypervariable region. The analyses revealed an average 10...
ContextThe prevalence and distribution of gonococcal chlamydial infections in the general population are poorly understood. Development nucleic acid amplification tests, such as ligase chain reaction assay, provides new opportunities to estimate untreated population.ObjectiveTo overall describe patterns infection within specific demographic subgroups young adult Baltimore, Md.Design SettingCross-sectional behavioral survey based on a probability sample Baltimore households with collection...
To estimate the impact of prevalent and incident herpes simplex virus type 2 (HSV-2) infection on acquisition human immunodeficiency 1 (HIV-1), stored serum samples from a cohort 2732 HIV-1-seronegative patients attending 3 sexually transmitted clinics reproductive tract clinic in Pune, India, were screened for HSV-2-specific antibodies. Incident HSV-2 was defined serologically as "recent" if negative result testing could be documented within previous 6 months or "remote" >6 had elapsed...
Objectives: To describe the risk factors, clinical presentation, and long-term follow up of patients enrolled in a cohort HIV-infected who were diagnosed treated for neurosyphilis. Methods: Comprehensive demographic, clinical, therapeutic data collected prospectively on all between 1990 2006. Patients with neurosyphilis if they had positive syphilis serologies any following: (a) one or more cerebrospinal fluid abnormalities lumbar puncture [white blood cells >10/μl; protein >50 mg/dl;...
Abstract Background: Although several previous case-control studies have investigated associations between sexually transmitted infections (STI) and prostate cancer, most focused on gonorrhea syphilis, two well-recognized, symptomatic STIs. Another STI of interest for carcinogenesis is trichomonosis, a less well recognized frequently asymptomatic with known involvement. We this infection in relation to incident cancer nested study within the Health Professionals Follow-up Study. Methods:...
Rapid diagnosis of bloodstream infections (BSIs) in the emergency department (ED) is challenging, with turnaround times exceeding timeline for rapid diagnosis. We studied usefulness procalcitonin as a marker BSI 367 adults admitted to our ED symptoms systemic infection. Serum samples obtained at same time blood cultures were available from 295 patients. Procalcitonin levels compared culture results and other clinical data during visit. less than 0.1 ng/mL considered negative; all positive....
Chronic wounds contain complex polymicrobial communities of sessile organisms that have been underappreciated because limitations standard culture techniques. The aim this work was to combine recently developed next-generation investigative techniques comprehensively describe the microbial characteristics chronic wounds. Tissue samples were obtained from 15 patients with presenting Johns Hopkins Wound Center. Standard bacteriological cultures demonstrated an average three common bacterial...
Background: Millions of women in the United States receive cervical screening sexually transmitted disease (STD), family planning, and primary care clinical settings. Objective: To inform current programs. Design: Measurement abnormal Papanicolaou (Pap) tests high-risk human papillomavirus (HPV) infection among demographically diverse who received routine from January 2003 to December 2005 States. Setting: 26 STD, clinics 6 U.S. cities. Patients: 9657 age 14 65 years receiving screening....
Background. Ceftriaxone is the foundation of currently recommended gonorrhea treatment. There an urgent need for backup treatment options patients with cephalosporin allergy or infections due to suspected cephalosporin-resistant Neisseria gonorrhoeae. We evaluated efficacy and tolerability 2 combinations existing noncephalosporin antimicrobials urogenital gonorrhea. Methods. conducted a randomized, multisite, open-label, noncomparative trial in 5 outpatient sexually transmitted disease...
Clostridium difficile infection is the most common health-care-associated in USA. We assessed safety and efficacy of ridinilazole versus vancomycin for treatment C infection.We did a phase 2, randomised, double-blind, active-controlled, non-inferiority study. Participants with signs symptoms positive diagnostic test result were recruited from 33 centres USA Canada randomly assigned (1:1) to receive oral (200 mg every 12 h) or (125 6 10 days. The primary endpoint was achievement sustained...
The authors' goal was to investigate the relationship between depression and HIV risk behaviors or sexually transmitted disease (STD) diagnosis at an urban STD clinic.Using audio computer-assisted self-interview, 671 clinic patients answered questions about in a large-scale, cross-sectional study. A subset of (N=201) evaluated for current major depressive disorder by interviewers using nonpatient edition Structured Clinical Interview DSM-IV.Depressed were more likely have sex money drugs,...
Project RESPECT was a multisite randomized trial comparing three clinic-based interventions’ ability to increase condom use and prevent infection with HIV sexually transmitted diseases. Because had guiding concepts that determined the content of sessions, authors investigated how intervention operated using these theoretical variables. Growth curve analysis structural equation modeling estimated correlation between intentions toward self-reports isolated treatment effects on mediating...
Background: Many studies measure sex behavior to determine the efficacy of sexually transmitted disease (STD)/HIV prevention interventions. Goal: To how well measured reflects STD incidence. Study Design: Data from a trial (Project RESPECT) were analyzed compare and incidence (gonorrhea, chlamydia, syphilis, HIV) during two 6-month intervals. Results: A total 2879 persons had 5062 six-monthly exams interviews; 8.9% new in 6 months. Incidence was associated with demographic factors but only...
The Gonococcal Isolate Surveillance Project is a national sentinel surveillance system to estimate levels and monitor trends of antimicrobial resistance in prospectively collected isolates of<i>Neisseria gonorrhoeae</i>. Of 6204 evaluated from 21 clinic sites between September 1987 December 1988, 21% met at least one the criteria for penicillin, tetracycline, cefoxitin, or spectinomycin; 2.2% were penicillinase-producing<i>N gonorrhoeae</i>; 1.0% had high-level plasmid-mediated tetracycline...
Gonorrhea has a focused geographic distribution characterized by high incidence rates in defined "core" areas and decreased as the radial distance from central core increases. Dense cor group transmission long been hypothesized.We have previously mapped sexually transmitted disease (STD) Baltimore census tracts using STD morbidity data interfaced with information system. Core were standard definition based on gonorrhea distribution. We studied spatial patterns between sexual partners,...
In Brief Background: Studies in antenatal care clinics suggest that lower genital tract infections (LGTI) may be associated with adverse pregnancy outcomes (APO). We sought to characterize patterns and determine whether LGTI are independently preterm birth and/or low-birth weight among a high-risk public sexually transmitted diseases (STD) clinic population. Methods: Electronic STD medical records state were matched for 730 pregnant women age 13 49 tested 5 treatable (bacterial vaginosis,...
The decision to perform lumbar puncture in patients with asymptomatic human immunodeficiency virus (HIV) infection and syphilis is controversial. Centers for Disease Control Prevention recommend certain criteria that warrant puncture. Here, we assess the performance of these detecting neurosyphilis (ANS).Eligible subjects consisted all concurrent HIV a prospective clinical cohort who had no neurologic symptoms at time We retrospectively applied different stratification calculate ANS: (1)...