A5040591896- Ocular Oncology and Treatments
- Cutaneous Melanoma Detection and Management
- Ophthalmology and Visual Impairment Studies
- Intraocular Surgery and Lenses
- Glaucoma and retinal disorders
- Cystic Fibrosis Research Advances
- Hemoglobinopathies and Related Disorders
- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Ocular Infections and Treatments
- Primary Care and Health Outcomes
- Healthcare Systems and Technology
- Indoor Air Quality and Microbial Exposure
- Central Venous Catheters and Hemodialysis
- Multiple Sclerosis Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Childhood Cancer Survivors' Quality of Life
- Iron Metabolism and Disorders
- Antifungal resistance and susceptibility
- Neonatal Respiratory Health Research
- HIV/AIDS Research and Interventions
- Brain Metastases and Treatment
- Vascular Procedures and Complications
- Electronic Health Records Systems
- Air Quality and Health Impacts
Johns Hopkins University
2015-2025
Center for Global Health
2020-2021
Doheny Eye Institute
2018
University of California, Los Angeles
1989-2018
May Institute
2017
London School of Hygiene & Tropical Medicine
2017
Office of International Affairs
2017
University of Baltimore
2004-2017
Johns Hopkins Hospital
1988-2017
Johns Hopkins Medicine
1992-2016
Background— Clinic-based observational studies in men have reported that obstructive sleep apnea is associated with an increased incidence of coronary heart disease. The objective this study was to assess the relation incident disease and failure a general community sample adult women. Methods Results— A total 1927 2495 women ≥40 years age free at time baseline polysomnography were followed up for median 8.7 prospective longitudinal epidemiological study. After adjustment multiple risk...
Rationale: Although obstructive sleep apnea is associated with physiological perturbations that increase risk of hypertension and are proatherogenic, it uncertain whether increased stroke in the general population.Objectives: To quantify incidence ischemic a community-based sample men women across wide range apnea.Methods: Baseline polysomnography was performed between 1995 1998 longitudinal cohort study. The primary exposure apnea–hypopnea index (OAHI) outcome incident stroke.Measurements...
To describe the development and performance of a brief questionnaire designed to measure functional impairment caused by cataract (the VF-14).Observational cross-sectional study. Patients were recruited between July 15 December 15, 1991.Patients from practices 70 ophthalmologists, located in Columbus, Ohio (N = 21), St Louis, Mo 26), Houston, Tex 23).Seven hundred sixty-six patients undergoing surgery for first time.Preoperative best corrected visual acuity each eye; scores on VF-14, new...
Objectives: To report initial mortality findings from the Collaborative Ocular Melanoma Study (COMS) randomized clinical trial of iodine 125 brachytherapy vs enucleation for treatment choroidal melanoma.Methods: Patients were evaluated eligibility at 43 participating centers in United States and Canada.Eligible consenting patients assigned randomly time enrollment to or I brachytherapy.Patients examined specified intervals after data collection purposes.Findings presented herein are based on...
<h3>Objective</h3> To describe the time between treatment for choroidal melanoma and first diagnosis of metastatic disease, sites metastasis, treatments metastasis death. <h3>Design</h3> Prospective, longitudinal follow-up patients diagnosed with who were enrolled in 2 randomized trials conducted by Collaborative Ocular Melanoma Study Group. <h3>Methods</h3> Systemic laboratory evaluations performed during according to a standard protocol 2320 without evidence or other primary cancer at...
<h3>Background</h3> Despite speculation that clinical information technologies will improve and financial outcomes, few studies have examined this relationship in a large number of hospitals. <h3>Methods</h3> We conducted cross-sectional study urban hospitals Texas using the Clinical Information Technology Assessment Tool, which measures hospital's level automation based on physician interactions with system. After adjustment for potential confounders, we whether greater hospital was...
Rationale: The prevalence in cystic fibrosis (CF) of respiratory cultures with methicillin-resistant Staphylococcus aureus (MRSA) has dramatically increased over the last 10 years, but effect MRSA on FEV1 decline CF is unknown.Objectives: To determine association between infection and children adults CF.Methods: This was a 10-year cohort study using Cystic Fibrosis Foundation patient registry from 1996–2005. We studied individuals who developed new tract infection. Repeated-measures...
Objective To evaluate the prophylactic use of enteral fluconazole to prevent invasive candidal infections in critically ill surgical patients. Summary Background Data Invasive fungal are increasingly common ill, especially Although prophylaxis has been proven effective certain high-risk patients such as bone marrow transplant patients, few studies have focused on and prevention infection. Methods The authors conducted a prospective, randomized, placebo-controlled trial single-center,...
Context.-Adolescents are at highest risk for infection with Chlamydia trachomatis, an important preventable cause of pelvic inflammatory disease and subse- quent tubal factor infertility in US women.Current guidelines delivery adolescent primary care services recommend yearly chlamydia screening those females considered to be risk.Objectives.-To describe the epidemiology prevalent incident among assess appropriate interval define factors that would identify target...
Background: Although ophthalmologists have long recognized that visual acuity alone is an inadequate measure of impairment, the need for and outcomes cataract surgery historically been assessed in terms acuity.Purpose: To examine relation among different outcome measures, including a 14-item instrument designed to functional impairment caused by (the VF-14), at 4 months after surgery. Methods:The authors performed longitudinal study 552 patients undergoing first eye 1 75 practicing Columbus,...
Many studies have attempted to identify histologic features that aid in the distinction of atypical hyperplasia (AH) from without atypia and well-differentiated endometrioid carcinoma, but few evaluated reproducibility these diagnoses. Five pathologists independently reviewed 100 endometrial biopsy curettage specimens chosen represent entire spectrum proliferative lesions endometrium, including endometrium (PEM), atypia, AH, carcinoma. Slides were twice for diagnosis, with an intervening...
More than 200,000 patients with end-stage renal disease undergo dialysis in the United States each year, about two thirds for-profit centers. Economic pressures, such as decline inflation-adjusted Medicare payments for dialysis, may compromise quality of care. Facilities also be reluctant to refer evaluated transplantation because loss revenues from after receive transplants. It is unknown whether facilities respond more aggressively not-for-profit these financial pressures. Therefore, we...
Longitudinal linkages between intentional exposure to x-rated material and sexually aggressive behavior were examined among youth 10–15 year olds surveyed nationally in the United States. At Wave 1 2006, participants (n = 1,588) queried about these exposures outcomes preceding 12 months. 2 data 1,206) collected approximately months after 3 1,159) 24 1. Thus, for this project represent a 36-month time frame. A marginal model with generalized estimating equations was used population-average...
Summary Women with pseudomyxoma peritonei (PMP), characterized by multifocal mucinous implants (disseminated peritoneal adenomucinosis), often have synchronous appendiceal and ovarian tumors. There has been considerable debate as to whether the tumors are secondary tumor or independent primary tumors; latter usually classified of low malignant potential (MLMP). It reported that cytokeratins (CK) 7, 18, 20, carcinoembryonic antigen (CEA). human alveolar macrophage 56 (HAM-56) useful markers...
Purpose To describe the predictive value of liver function tests (LFTs), chest x-ray, and diagnostic imaging for detecting melanoma metastasis during routine follow-up after treatment choroidal melanoma. Materials Methods Prospective longitudinal patients enrolled onto two randomized trials was conducted by Collaborative Ocular Melanoma Study (COMS) Group. Baseline annual or semiannual systemic laboratory evaluations were performed according to a standard protocol 2,320 on COMS. Results COMS...
To evaluate the Johns Hopkins Hospital experience with 136 thymomas over past 40 years. This number of patients allowed quantitative estimation independent influence common clinicopathologic risk factors using multivariate analysis.Thymomas vary widely in terms recurrence and on overall survival. Several series have indicated importance initial tumor invasion, as well extent surgical resection, predictors survival after thymoma resection. However, findings been equivocal when other prognosis...
Most individuals with cystic fibrosis (CF) carry one or two mutations that result in a maturation defect of the full-length protein. One such mutation, ΔF508, results mutant membrane glycoprotein fails to progress apical membrane, where wild-type protein normally functions as cyclic AMP-regulated chloride channel. 4-Phenylbutyrate (Buphenyl), an orally bioavailable short chain fatty acid, modulates heat shock expression and restores ΔF508 vitro vivo. We performed randomized, double-blind,...