Age-related macular degeneration (AMD) is one of the four most common causes blindness in United States. Retinal manifestations AMD can be categorized as either atrophic or neovascular/exudative. To best our knowledge, proportion patients legally blind due to neovascular/exudative this disease has not been previously reported. Data from two studies, Framingham Eye Study and a large case-control study, demonstrate that vast majority with legal have form disease. Seventy-nine percent eyes...

Objectives: To report initial mortality findings from the Collaborative Ocular Melanoma Study (COMS) randomized clinical trial of iodine 125 brachytherapy vs enucleation for treatment choroidal melanoma.Methods: Patients were evaluated eligibility at 43 participating centers in United States and Canada.Eligible consenting patients assigned randomly time enrollment to or I brachytherapy.Patients examined specified intervals after data collection purposes.Findings presented herein are based on...

We determined the therapeutic effect of fluorouracil (5-FU) in combination with folinic acid (FA) patients measurable recurrent or metastatic carcinoma colon rectum by comparing it to standard 5-FU therapy a prospective randomized controlled trial. Patients were receive either FA, 200 mg/m2/d for five consecutive days, nothing. All received 5-FU, 370 days on first course, subsequent dose modifications maintain equal toxicity two arms. One hundred thirty entered trial and only excluded from...

This study was designed to assess the role of dosage chemotherapy for treatment metastatic breast cancer. One hundred thirty-three patients without prior disease were randomly allocated receive two different dose levels cyclophosphamide (C), methotrexate (M), and fluorouracil (F), administered intravenously (IV) every 3 weeks. Patients stratified by sites (visceral, bone, or soft-tissue dominant) interval from primary surgery first recurrence. Doses on higher-dose arm 600 mg/m2 (C,F) 40 (M)...

The Wilmer Retinal Vascular Center9s experience with central serous chorioretinopathy from 1970 to the end of 1979 was reviewed and compared previous studies. Retrospective analysis 73 patients seen at follow-up suggests no clinically significant effect focal argon laser photocoagulation on final visual acuity or recurrence rate. Patients initial 20/20 remained that level, less than 20/30 gained, average, two three Snellen lines follow-up. Approximately one-third both untreated treated had...

Associations between thromboembolism and malignancy, usually widespread, hormonal and/or chemotherapy have been previously reported. We performed a randomized trial of tamoxifen 30 mg/d for 2 years (T) versus T plus 6 months intravenous with cyclophosphamide, methotrexate, fluorouracil (CMF) postmenopausal women involved axillary nodes positive estrogen receptor (ER) or progesterone (PgR) status following primary therapy breast cancer.We observed one more thromboembolic events in 48 353...

Functional verification is widely acknowledged as the bottleneck in hardware design cycle. This paper addresses one of main challenges simulation based (or dynamic verification), by providing a new approach for Coverage Directed Test Generation (CDG). on Bayesian networks and computer learning techniques. It provides an efficient way closing feedback loop from coverage domain back to generator that produces stimuli tested design. In this paper, we show how apply CDG problem. Applying...

• Retinopathy in systemic lupus erythematosus generally consists of cotton-wool spots with or without intraretinal hemorrhages. Although rare, a more severe retinal vaso-occlusive disease, termed<i>retinal vasculitis</i>, has been described. We report data from 11 patients SLE and vasoocclusive disease. Visual outcome was often poor, 55% the involved eyes suffering visual loss, frequently to an acuity worse than 20/200. The feature significantly associated vascular disease central nervous...

In this article we present novel learning methods for estimating the quality of results returned by a search engine in response to query. Estimation is based on agreement between top full query and its sub-queries. We demonstrate usefulness estimation several applications, among them improvement retrieval, detecting queries which no relevant content exists document collection, distributed information retrieval. Experiments TREC data robustness effectiveness our algorithms.

One hundred ninety-two patients with previously untreated metastatic cancer (102 non-small-cell lung [NSCLC]; 90 colorectal cancer) were randomized to receive either ad lib nutritional intake (control group) or specific intervention during a 12-week study period when chemotherapy was administered. Those interventions counselled take oral nutrients caloric equal 1.7 1.95 times their basal energy expenditure, depending on pretreatment status ("standard" group). An augmented group have...

• Light and transmission electron microscopic examinations of two postmortem eyes from an 80-year-old woman with clinically well-documented Best's macular dystrophy disclosed striking abnormalities in the retinal pigment epithelium (RPE), photoreceptors, sub-RPE area. The RPE cells were flattened, displacement nuclei toward apex diffuse deposition abnormal lipofuscin pleomorphic melanolipofuscin granules. A PAS-positive, acid-mucopolysaccharide-negative, electron-dense, finely granular...

• Of 217 patients in whom anterior ischemic optic neuropathy (AION) was diagnosed during the period from 1975 to 1985, verifiable medical information obtained for 212 (98%). Over a median follow-up of three years, no group had an increased mortality rate over that age-, sex-, and race-matched controls; however, with "idiopathic" AION systemic hypertension who developed nonarteritic statistically significant risk experiencing cerebrovascular events myocardial infarctions compared...

Patients with senile macular degeneration and exudative maculopathy in one eye drusen the second have a 3% to 7% risk per year of developing during first three years following their initial presentation. The is same for patients new vessel membranes or other types eye. Second eyes which changes develop are more likely larger numbers greater confluence (or both) initially. data from this study were analyzed using Kaplan-Meier technique estimation, method (to our knowledge) not previously...

• Low-contrast charts were used to investigate the possibility that patients with drusen have visual deficits not detected by standard Snellen charts. We compared performance on Regan letter between 52 eyes and acuity of 20/20 27 control eyes. The group read fewer letters than all tested. This difference increased as contrast decreased. loss correlated severity. Twenty-one normal also tested a Ginsburg sensitivity chart age-matched controls. results showed at high spatial frequencies peak...

• One hundred three patients with neovascular maculopathy and relatively recent vision loss were surveyed to determine the most frequent symptoms assess reliability of Amsler grid in helping detect early symptoms. Blurred distortion, often near vision, first reported by patients. Of 49 who said that they observing on a regular basis, only five indicated abnormality was visual symptom. However, all but did notice an during office examination, suggesting noncompliance as probable explanation...

• Choroidopathy in association with systemic lupus erythematosus (SLE) is a clinically unusual manifestation, previously described only six patients, to our knowledge. We have followed up patients SLE and choroidopathy manifested by multifocal, serous elevations of the retinal pigment epithelium sensory retina. In four macular involvement was present, they suffered visual loss. Two eyes two progressed large, bullous, exudative detachments. three whom control disease achieved, detachments...

The COMS Randomized Trial of Iodine 125 Brachytherapy for Choroidal Melanoma, III: Initial Mortality Findings