A5100763335- Cystic Fibrosis Research Advances
- Stuttering Research and Treatment
- Child and Adolescent Psychosocial and Emotional Development
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Child Abuse and Trauma
- Youth Substance Use and School Attendance
- Family and Disability Support Research
- Infant Development and Preterm Care
- Phonetics and Phonology Research
- Birth, Development, and Health
- Asthma and respiratory diseases
- Autism Spectrum Disorder Research
- Maternal Mental Health During Pregnancy and Postpartum
- Adolescent and Pediatric Healthcare
- Usability and User Interface Design
- Virus-based gene therapy research
- Neurobiology of Language and Bilingualism
- Innovative Human-Technology Interaction
- Language, Discourse, Communication Strategies
- Child and Adolescent Health
- Homelessness and Social Issues
- Ecology and Vegetation Dynamics Studies
- Antimicrobial Resistance in Staphylococcus
- Intimate Partner and Family Violence
McMaster University
2013-2025
Montclair State University
2016-2025
Immunome (United States)
2025
Cystic Fibrosis Foundation
2015-2024
University of Hong Kong
2020-2024
Rotunda Hospital
2012-2023
John Hunter Hospital
2004-2023
Google (United States)
2013-2022
Colorado State University
2022
University of Newcastle Australia
2004-2020
Cystic fibrosis is a life-limiting disease that caused by defective or deficient cystic transmembrane conductance regulator (CFTR) protein activity. Phe508del the most common CFTR mutation.We conducted two phase 3, randomized, double-blind, placebo-controlled studies were designed to assess effects of lumacaftor (VX-809), corrector, in combination with ivacaftor (VX-770), potentiator, patients 12 years age older who had and homozygous for mutation. In both studies, randomly assigned receive...
Background. The Health Utilities Index Mark 3 (HUI3) is a generic multiattribute preference-based measure of health status and health-related quality life that widely used as an outcome in clinical studies, population surveys, the estimation quality-adjusted years, economic evaluations. HUI3 consists eight attributes (or dimensions) status: vision, hearing, speech, ambulation, dexterity, emotion, cognition, pain with 5 or 6 levels per attribute, varying from highly impaired to normal....
The complement system is an important mediator of the acute inflammatory response, and effective inhibitor would suppress tissue damage in many autoimmune diseases. Such might be found among endogenous regulatory proteins that block enzymes activate C3 C5. Of these proteins, receptor type 1 (CR1; CD35) has most inhibitory potential, but its restriction to a few cell types limits function vivo. This limitation was overcome by recombinant, soluble human CR1, sCR1, which lacks transmembrane...
A new approach in the treatment of cystic fibrosis involves improving function mutant transmembrane conductance regulator (CFTR). VX-770, a CFTR potentiator, has been shown to increase activity wild-type and defective cell-surface vitro.We randomly assigned 39 adults with at least one G551D-CFTR allele receive oral VX-770 every 12 hours dose 25, 75, or 150 mg placebo for 14 days (in part 1 study) 250 28 2 study).At day 28, group subjects who received median change nasal potential difference...
Chronic childhood illness, disability, and psychosocial problems are receiving major attention in current pediatric care. Much of the evidence associating chronic physical mental health adjustment has come from clinic-based studies is often inconsistent its conclusions. This paper reports findings Ontario Child Health Study, an epidemiologic survey 3,294 children 4 to 16 years age general community, concerning relationship psychiatric disorders social among with medical conditions, long-term...
<h3>Background</h3> VX-809, a cystic fibrosis transmembrane conductance regulator (CFTR) modulator, has been shown to increase the cell surface density of functional <i>F508del-CFTR</i> in vitro. <h3>Methods</h3> A randomised, double-blind, placebo-controlled study evaluated safety, tolerability and pharmacodynamics VX-809 adult patients with (n=89) who were homozygous for mutation. Subjects randomised one four 28 day dose groups (25, 50, 100 200 mg) or matching placebo. <h3>Results</h3> The...
<h3>Background:</h3> Nationally representative Canadian data on the prevalence of child abuse and its relation with mental disorders are lacking. We used contemporary, nationally to examine 3 types (physical abuse, sexual exposure intimate partner violence) their association 14 conditions, including suicidal ideation suicide attempts. <h3>Methods:</h3> obtained from 2012 Community Health Survey: Mental Health, collected 10 provinces. Respondents aged 18 years older were asked about selected...
Abstract A significant percentage of children with disruptive behaviour disorders do not receive mental health assistance. Utilization is lowest among groups whose are at greatest risk. To increase the availability, accessibility, and cost efficacy parent training programs, this prospective randomized trial compared a large group community‐based program to clinic‐based individual (FT) program. All families junior kindergartners in Hamilton public separate school boards were sent checklist...
Protective mucus coatings typically trap and rapidly remove foreign particles from the eyes, gastrointestinal tract, airways, nasopharynx, female reproductive thereby strongly limiting opportunities for controlled drug delivery at mucosal surfaces. No synthetic system composed of biodegradable polymers has been shown to penetrate highly viscoelastic human mucus, such as non-ovulatory cervicovaginal a significant rate. We prepared nanoparticles diblock copolymer poly(sebacic acid)...
YSTIC FIBROSIS (CF) IS THE most common lethal autosomal recessive disorder in white individuals. 1Individuals with CF are living longer, and the median predicted survival age is now older than 37 years. 2The cause of death respiratory failure secondary to pulmonary infection.While Pseudomonas aeruginosa Burkholderia cepacia complex pathogens commonly associated a shortened life span, there has been an increase prevalence several potentially pathogenic microorganisms CF.Methicillin-resistant...
Rationale: The prevalence in cystic fibrosis (CF) of respiratory cultures with methicillin-resistant Staphylococcus aureus (MRSA) has dramatically increased over the last 10 years, but effect MRSA on FEV1 decline CF is unknown.Objectives: To determine association between infection and children adults CF.Methods: This was a 10-year cohort study using Cystic Fibrosis Foundation patient registry from 1996–2005. We studied individuals who developed new tract infection. Repeated-measures...
Mucoadhesive particles (MAP) have been widely explored for pulmonary drug delivery because of their perceived benefits in improving particle residence the lungs. However, retention adhesively trapped airway mucus may be limited by physiologic clearance mechanisms. In contrast, that avoid mucoadhesion and diameters smaller than mesh spacings rapidly penetrate layers [mucus-penetrating (MPP)], which we hypothesized would provide prolonged lung compared to MAP. We vivo behaviors variously...
Background: Autism spectrum disorder (ASD) is characterized by notable phenotypic heterogeneity, which often viewed as an obstacle to the study of its etiology, diagnosis, treatment, and prognosis. On basis empirical evidence, instead three binary categories, upcoming edition DSM 5 will use two dimensions – social communication deficits (SCD) fixated interests repetitive behaviors (FIRB) for ASD diagnostic criteria. Building on this proposed model, it would be useful consider whether data...
Gene therapy has emerged as an alternative for the treatment of diseases refractory to conventional therapeutics. Synthetic nanoparticle-based gene delivery systems offer highly tunable platforms therapeutic genes. However, inability achieve sustained, high-level transgene expression in vivo presents a significant hurdle. The respiratory system, although readily accessible, remains challenging target, effective mandates colloidal stability physiological fluids and ability overcome biological...
Video-based media spaces are designed to support casual interaction between intimate collaborators. Yet transmitting video is fraught with privacy concerns. Some researchers suggest that the stream be filtered mask out potentially sensitive information. While a variety of filtering techniques exist, they have not been evaluated for how well safeguard privacy.