A5010243275- HIV/AIDS Research and Interventions
- Mobile Health and mHealth Applications
- Global Maternal and Child Health
- ICT in Developing Communities
- SARS-CoV-2 detection and testing
- Biomedical and Engineering Education
- Child Nutrition and Water Access
- Infant Development and Preterm Care
- Pneumonia and Respiratory Infections
- Tuberculosis Research and Epidemiology
- HIV/AIDS drug development and treatment
- Neonatal and Maternal Infections
- Transportation and Mobility Innovations
- Biosensors and Analytical Detection
- Biotechnology and Related Fields
- Global Health and Surgery
- Neonatal Respiratory Health Research
- HIV Research and Treatment
- Blood donation and transfusion practices
- Blood groups and transfusion
- HIV/AIDS Impact and Responses
- Genomics and Rare Diseases
- Maternal and Neonatal Healthcare
- Clinical Laboratory Practices and Quality Control
- Sepsis Diagnosis and Treatment
Northwestern University
2010-2024
Center for Assessment
2024
Kellogg's (Canada)
2014-2020
Center for Innovation
2015
Mayor's Fund to Advance New York City
2008
There are inefficiencies in current approaches to monitoring patients on antiretroviral therapy sub-Saharan Africa. Patients typically attend clinics every 1 3 months for clinical assessment. The clinic costs comparable with the of drugs themselves and CD4 counts measured 6 months, but rarely switched second-line therapies. To ensure sustainability treatment programmes, a transition more cost-effective delivery is needed. In contrast count, measurement level HIV RNA plasma (the viral load)...
Stakeholders agree that supporting high-quality diagnostics is essential if we are to continue make strides in the fight against human immunodeficiency virus (HIV) and tuberculosis. Despite need strengthen existing laboratory infrastructure, which includes expanding developing new laboratories, there clear diagnostic needs where conventional support insufficient. Regarding HIV, rapid point-of-care (POC) testing for initial HIV diagnosis has been successful, but several remain. For...
In recent years, there has been significant investment from both the private and public sectors in development of diagnostic technologies to meet need for human immunodeficiency virus (HIV) tuberculosis testing low-resource settings. Future investments should ensure that most appropriate are adopted settings where they will have a sustainable impact. Achieving these aims requires involvement many stakeholders, as their needs, operational constraints, priorities often distinct. Here, we...
Abstract Background Each year an estimated 2.3 million newborns die in the first 28 days of life. Most these deaths are preventable, and high-quality neonatal care is fundamental for surviving thriving. Service readiness used to assess capacity hospitals provide care, but current health facility assessment (HFA) tools do not fully evaluate inpatient small sick newborn (SSNC). Methods Health systems ingredients SSNC were identified from international guidelines, notably World Organization...
Thirty million small and sick newborns worldwide require inpatient care each year. Many receive antibiotics for clinically diagnosed infections without blood cultures, the current 'gold standard' neonatal infection detection. Low culture use hampers appropriate antibiotic use, fuelling antimicrobial resistance (AMR) which threatens newborn survival. This study analysed gap between prescribing in hospitals implementing with Newborn Essential Solutions Technologies (NEST360) Kenya, Malawi,...
Problem definition: Healthcare systems in resource-limited settings rely on diagnostic networks which medical samples (e.g., blood, sputum) and results need to be transported between geographically dispersed healthcare facilities centralized laboratories. Academic/practical relevance: Existing sample transportation (ST) typically operate fixed schedules, do not account for demand variability lead unnecessary visits as well delays. Methodology: We design an optimized (OST) system that...
Millions of newborns die annually from preventable causes, with the highest rates occurring in Africa. Reducing neonatal mortality requires investment to scale hospital care, which includes providing hospitals appropriate technology care for small and sick newborns. Expensive medical devices designed high-resource settings often fail withstand conditions low-resource hospitals, including humidity, dust, frequent user turnover, complex maintenance, lack stable power, or difficulty sourcing...
Viral load (VL) quantification is an important tool in determining newly developed drug resistance or problems with adherence to antiretroviral therapy (ART) HIV-positive patients. VL monitoring becoming the standard of care many resource-limited settings. Testing settings may require sampling by fingerstick because general shortages skilled phlebotomists and expense venepuncture supplies their distribution.To assess feasibility ease collecting 150 µL capillary blood needed for use a novel...
Abstract Background Medical devices are critical to providing high-quality, hospital-based newborn care, yet many of these unavailable in low- and middle-income countries (LMIC) not designed be suitable for settings. Target Product Profiles (TPPs) often utilised at an early stage the medical device development process enable user-defined performance characteristics a given setting. TPPs can also applied assess profile match existing context. Methods We developed initial 15 product categories...
Diagnostics in many low- and middle-income countries are conducted through centralized laboratory networks. Samples collected from patients at remote point-of-care health facilities, diagnostic tests performed laboratories. Sample transportation systems that deliver samples test results crucial for timely diagnosis treatment such However, they often lack the accurate data (eg, quantity location of prepared collection) required efficient operation.
Medical products used in the developed world often fail to adequately serve resource-limited settings where electricity, transportation and health care workers are not readily available. We suggest that problem is only a lack of coordinated financial resources purchase existing medical products, but also specifically designed for settings. While donor organisations with focus on global increasingly willing bear additional risk research development such high-impact corporations still...
Background Xpert MTB/RIF (Xpert) is being widely adopted in high TB burden countries. Analysis needed to guide the placement of devices within health systems optimize tuberculosis (TB) case detection rate (CDR). Methods We used epidemiological and operational data from Uganda (139 sites serving 87,600 individuals tested for TB) perform a model-based comparison following strategies devices: 1) Health center level (sites ranked by size national referral hospitals care III centers), 2) Smear...
Early infant diagnosis of HIV infection is challenging in sub-Saharan Africa, particularly rural areas, leading to delays and treatment. Use a point-of-care test would overcome many challenges. This study evaluated the validity novel p24 antigen detection (LYNX) urban settings southern Zambia.
Problem Definition: Healthcare systems in resource-limited settings rely on diagnostic networks which medical samples (e.g. blood, sputum) and results need to be transported between geographically dispersed healthcare facilities centralized laboratories. Due lack of updated information, existing sample transportation (ST) typically operate fixed schedules do not account for demand variability.Academic / Practical Relevance: We present an innovative approach timely collection information...
Viral load monitoring for HIV treatment is recommended but not feasible in many settings. A point-of-care test using capillary blood would increase access may require up to 200 μL of achieve a lower limit detection 1000 copies/mL. This cross-sectional study evaluated the feasibility collecting as well collection preferences among adults rural Zambia. Adults seeking counseling and testing at Macha Hospital were recruited 2015. Capillary was collected four 50 tubes. Blood categorized complete...
The COVID-19 pandemic has impacted the daily lives of individuals across world as multiple variants continue introducing new complexities. In December 2021, which is when we conducted our study, pressure to resume normalcy life was mounting a variant, Omicron, rapidly spreading. A variety at-home tests detecting SARS-CoV-2, known general public “COVID tests,” were available for consumers purchase. this conjoint analysis utilizing an internet-based survey by presenting (n = 583) with 12...
Background As more preterm infants survive, complications of birth, including retinopathy prematurity (ROP), become prevalent. ROP rates and blindness from are higher in low-income middle-income countries, where exposure to risk factors can be detection treatment under-resourced or non-existent. Access low-cost imaging devices would improve remote screening capabilities for ROP. Methods Target product profiles (TPPs) developed early the medical device development process define setting,...
TheCenter for Innovation in Point-of-Care Technologies HIV/AIDS at Northwestern University (C-THAN) is a partner the Research Network (POCTRN) of National Institutes Biomedical Imaging and Bioengineering. POCTRN’s mission to drivethe development appropriate point-of-care (POC) diagnostic technologies through collaboration that merges scientific technological capabilities with clinical need. C-THAN develops POC improved management low- middle-income countries focus on sub-Saharan Africa....
Background: Xpert MTB/RIF (Xpert) is being widely adopted in high TB burden countries. Analysis needed to guide the placement of devices within health systems optimize tuberculosis (TB) case detection.