Teri Roberts
A5051182904- Tuberculosis Research and Epidemiology
- Hepatitis C virus research
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Hepatitis B Virus Studies
- Mosquito-borne diseases and control
- Mycobacterium research and diagnosis
- HIV/AIDS drug development and treatment
- Viral Infections and Vectors
- Liver Disease Diagnosis and Treatment
- HIV, Drug Use, Sexual Risk
- Pneumocystis jirovecii pneumonia detection and treatment
- Immune Cell Function and Interaction
- Viral Infections and Outbreaks Research
- Infectious Diseases and Tuberculosis
- Pharmaceutical Economics and Policy
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Hepatitis Viruses Studies and Epidemiology
- Nutrition and Health in Aging
- Burkholderia infections and melioidosis
- Diagnosis and treatment of tuberculosis
- SARS-CoV-2 detection and testing
- Respiratory viral infections research
- Reproductive tract infections research
Global Antibiotic Research & Development Partnership
2024
Stellenbosch University
2005-2023
International AIDS Society
2020-2022
South African Medical Research Council
2020
Médecins Sans Frontières
2012-2020
Médecins Sans Frontières
2019
Foundation for Innovative New Diagnostics
2017
Médecins Sans Frontières
2014-2017
Médecins Sans Frontières
2012
University of Cape Town
2010
Rationale: Contacts of patients with tuberculosis (TB) constitute an important target population for preventive measures because they are at high risk infection Mycobacterium and progression to disease.Objectives: We investigated biosignatures predictive ability incident TB.Methods: In a case–control study nested within the Grand Challenges 6-74 longitudinal HIV-negative African cohort exposed household contacts, we employed RNA sequencing, PCR, pair ratio algorithm in training/test set...
Despite immense progress in antiretroviral therapy (ART) scale-up, many people still lack access to basic standards of care, with our ability meet the Joint United Nations Programme on HIV/AIDS 90-90-90 treatment targets for dependent dramatic improvements diagnostics. The World Health Organization recommends routine monitoring ART effectiveness using viral load (VL) testing at 6 months and every 12 months, monitor adherence minimize failure, will publish its VL toolkit later this year....
Abstract Antigen-specific, MHC-restricted αβ T cells are necessary for protective immunity against Mycobacterium tuberculosis , but the ability to broadly study these responses has been limited. In present study, we used single-cell and bulk cell receptor (TCR) sequencing GLIPH2 algorithm analyze M. -specific sequences in two longitudinal cohorts, comprising 166 individuals with infection who progressed either ( n = 48) or controlled 118). We found 24 groups similar TCR-β sequences,...
The recent introduction of fluorescent bead-based technology, allowing the measurement multiples analytes in a single 25–50 µl sample has revolutionized study cytokine responses. However, such multiplex approaches may compromise ability these assays to accurately measure actual levels. This evaluates performance three commercially available immunoassays (Bio-Rad's Cytokine 17-plex kit; LINCO Inc's 29-plex and RnD System's Fluorokine-Multi Analyte Profiling (MAP) base kit A B). Inc was found...
There are inefficiencies in current approaches to monitoring patients on antiretroviral therapy sub-Saharan Africa. Patients typically attend clinics every 1 3 months for clinical assessment. The clinic costs comparable with the of drugs themselves and CD4 counts measured 6 months, but rarely switched second-line therapies. To ensure sustainability treatment programmes, a transition more cost-effective delivery is needed. In contrast count, measurement level HIV RNA plasma (the viral load)...
Background The accurate diagnosis of TB in HIV-infected patients, particularly with advanced immunosuppression, is difficult. Recent studies indicate that a lipoarabinomannan (LAM) assay (Clearview-TB®-ELISA) may have some utility for the patients; however, precise subgroup benefit from this technology requires clarification. LAM sputum samples has, hitherto, not been evaluated. Methods was measured and urine obtained 500 consecutively recruited ambulant suspected TB, 2 primary care clinics...
Abstract Improved tuberculosis diagnostics and tools for monitoring treatment response are urgently needed. We developed a robust simple, PCR-based host-blood transcriptomic signature, RISK6, multiple applications: identifying individuals at risk of incident disease, as screening test subclinical or clinical tuberculosis, treatment. RISK6 utility was validated by blind prediction using quantitative real-time (qRT) PCR in seven independent cohorts. Prognostic performance significantly...
The balance between effector and regulatory responses after Mycobacterium tuberculosis infection may dictate outcome progression to active disease. We investigated T cell in bacille Calmette-Guerin (BCG)-stimulated peripheral blood mononuclear cells whole cultures from persons with (TB), TB at the end of 6 months treatment, healthy control subjects latent infection. All 3 groups displayed BCG-induced increases phenotypes as defined by CD4(+)CD25(lo) CD4(+)CD25(hi) cells, respectively. In...
The inflammatory response to Mycobacterium tuberculosis (M.tb) at the site of disease is Th1 driven. Whether Th17 cytokines, IL-17 and IL-22, contribute this in humans unknown. We hypothesized that IL-22 pleural pericardial sites human (TB). studied effusions, established TB sites, from HIV-uninfected patients. Levels soluble cytokines were measured by ELISA MMP-9 luminex. Bronchoalveolar lavage or mycobacteria-specific T cell cytokine expression was analyzed intracellular staining. not...
We aimed to determine whether shotgun proteomic approaches could be used identify tuberculosis (TB)-specific biomarkers in the urine of well-characterised patients with active TB versus no TB. Patients suspected (n=63) were classified as: definite ( Mycobacterium positive culture, n=21); presumed latent-TB infection (LTBI) M. negative radiological features TB, a QuantiFERON-TB Gold In-Tube (QFT-IT) test and T-SPOT.TB test, n=24); non-TB/non-LTBI QFT-IT n=18). Urine proteins, range 3–50 kDa,...
There have been few reports on programmatic experience of viral hepatitis testing and treatment in resource-limited settings. To inform the development 2017 World Health Organization (WHO) guidance particular feasibility proposed recommendations, we undertook a survey across range organisations engaged with low- middle-income countries (LMICs). Our objective was to describe current B C practices settings different countries, as well key barriers or challenges encountered solutions promote...
The current low access to virological testing confirm chronic viraemic HCV infection in low- and middle-income countries (LMIC) is limiting the rollout of hepatitis C (HCV) care. Existing tests are complex, costly require sophisticated laboratory infrastructure. Diagnostic manufacturers need guidance on optimal characteristics a test needs have ensure greatest impact diagnosis treatment LMIC. Our objective was develop target product profile (TPP) for viraemia using global stakeholder...