A5002216866- Shoulder and Clavicle Injuries
- Shoulder Injury and Treatment
- Sports injuries and prevention
- Mosquito-borne diseases and control
- Malaria Research and Control
- Web and Library Services
- Library Science and Information Literacy
- Ovarian cancer diagnosis and treatment
- Library Science and Administration
- Children's Physical and Motor Development
- Invertebrate Immune Response Mechanisms
- Diversity and Career in Medicine
- Infant Development and Preterm Care
- Orthopedic Surgery and Rehabilitation
- Mycobacterium research and diagnosis
- Education Systems and Policy
- Cardiovascular Syncope and Autonomic Disorders
- Insect Resistance and Genetics
- Tuberculosis Research and Epidemiology
- PARP inhibition in cancer therapy
- Nerve Injury and Rehabilitation
- Design Education and Practice
- Insect symbiosis and bacterial influences
- Healthcare Policy and Management
- Ophthalmology and Visual Impairment Studies
University of Virginia
2025
University Hospital Southampton NHS Foundation Trust
2017-2024
George Washington University
2019-2024
Université de Nîmes
2022
Laboratoire d'Automatique, de Mécanique et d'Informatique Industrielles et Humaines
2020
Australian Catholic University
2019
Hampton University
2019
University of Canberra
2019
Southampton General Hospital
2016
Bradford Royal Infirmary
2010-2015
The antifungal defense of Drosophila is controlled by the spaetzle/Toll/cactus gene cassette. Here, a loss-of-function mutation in encoding blood serine protease inhibitor, Spn43Ac, was shown to lead constitutive expression peptide drosomycin, and this effect mediated spaetzle Toll products. Spaetzle cleaved proteolytic enzymes its active ligand form shortly after immune challenge, constitutively present Spn43Ac-deficient flies. Hence, Spn43Ac negatively regulates signaling pathway, does not...
PCR inhibition by nucleic acid extracts is a well known yet poorly described phenomenon. Inhibition assessment generally depends on the assumption that inhibitors affect all reactions to same extent; i.e. reaction of interest and control are equally susceptible inhibition. To test this we performed DNA from human urine samples, fresh EDTA using different reactions. When copurified were assessed two one appeared be inhibited whilst other was not. Further experiments various concentrations...
Abstract Background In the pre-intervention year of a randomized controlled trial investigating protective effects house screening against malaria-transmitting vectors, multi-factorial risk factor analysis study was used to identify factors that influence mosquito entry. Methods Mosquitoes were sampled using CDC light traps in 976 houses, each on one night, Farafenni town and surrounding villages during malaria-transmission season The Gambia. Catches from individual houses both (a) left...
Background The accurate diagnosis of TB in HIV-infected patients, particularly with advanced immunosuppression, is difficult. Recent studies indicate that a lipoarabinomannan (LAM) assay (Clearview-TB®-ELISA) may have some utility for the patients; however, precise subgroup benefit from this technology requires clarification. LAM sputum samples has, hitherto, not been evaluated. Methods was measured and urine obtained 500 consecutively recruited ambulant suspected TB, 2 primary care clinics...
Background: Posterior glenohumeral instability is an increasingly recognized cause of shoulder pain and dysfunction among young, active populations. Outcomes after posterior stabilization procedures are commonly assessed using patient-reported outcome measures including the Single Assessment Numeric Evaluation (SANE), Rowe score, American Shoulder Elbow Surgeons (ASES) visual analog scale (VAS) for pain. The clinical significance thresholds these arthroscopic labral repair (aPLR), however,...
Abstract Background Mosquito larval control may prove to be an effective tool for incorporating into integrated vector management (IVM) strategies reducing malaria transmission. Here the efficacy of microbial larvicides against Anopheles gambiae s.l. was tested in preparation a large-scale larviciding programme The Gambia. Methods impact water-dispersible (WDG) and corn granule (CG) formulations commercial Bacillus sphaericus strain 2362 ( Bs ; VectoLex ® ) thuringiensis var. israelensis...
Importance Patients with platinum-resistant or refractory ovarian high-grade serous carcinoma (PR-HGSC) have a poor prognosis and few therapeutic options. Preclinical studies support targeting PI3K/AKT/mTOR signaling in this setting, phase 1 study of the dual mTORC1/mTORC2 inhibitor vistusertib weekly paclitaxel showed activity. Objective To evaluate whether addition to improves clinical outcomes patients PR-HGSC. Design, Setting, Participants This 2, double-blind, placebo-controlled...
We examined the distribution of aquatic stages malaria vectors in a 400-km(2) area rural Gambia to assess practicality targeting larval control. During rainy season, peak period transmission, breeding sites were 70% more likely have anopheline larvae floodplain River than upland (P < 0.001). However, mosquitoes found some examples all habitats, apart from moving water. Habitats most often colonized by largest water bodies, situated near landward edge flood-plain, where culicine present. In...
Larviciding to control malaria was assessed in rural areas with extensive seasonal flooding. Larval and adult mosquitoes incidence were surveyed routinely four 100-km 2 either side of the Gambia River. Baseline data collected 2005. Microbial larvicide applied all water bodies by hand application water-dispersible granular formulations corn granules weekly from May November two 2006 other 2007 a cross-over design. The intervention associated reduction habitats late stage anopheline larvae an...
Alzheimer disease is characterized by extracellular plaques composed of Abeta peptides. We show here that these also contain the serine protease inhibitor neuroserpin and forms a 1:1 binary complex with N-terminal or middle parts Abeta(1-42) peptide. This inactivates as an tissue plasminogen activator blocks loop-sheet polymerization process characteristic members serpin superfamily. In contrast accelerates aggregation resulting species having appearance distinct from mature amyloid fibril....
Journal Article Role of Fish as Predators Mosquito Larvae on the Floodplain Gambia River Get access Vasilis Louca, Louca 1 1Corresponding author, e-mail: vasilis.louca@durham.ac.uk. Search for other works by this author on: Oxford Academic PubMed Google Scholar Martyn C. Lucas, Lucas School Biological and Biomedical Sciences, Durham University, DH1 3LE, United Kingdom Clare Green, Green Silas Majambere, Majambere Ulrike Fillinger, Fillinger Steve W. Lindsay Medical Entomology, Volume 46,...
Background: Active-duty military service members experience posterior glenohumeral instability at a rate that far outpaces of nonmilitary populations. While the outcomes after primary labral repair (PLR) in this population are promising, revision procedures remain poorly described. Purpose: To report midterm PLR active-duty patients. Study Design: Case series; Level evidence, 4. Methods: Patients who underwent from January 2011 through December 2018 by senior surgeon with minimum 5 years...
Abstract Background: Labral reconstruction is an increasingly utilized technique for the management of severe labral pathology. While several studies have demonstrated comparable outcomes to repair at short and midterm follow-up, few reported on influence patient-specific factors that may decision reconstruct or repair. Purpose: To analyze clinical a minimum 2 years follow-up patients undergoing primary versus reconstruction. We also sought associated with higher risk progressing revision...
A 68-year-old woman underwent arthroscopic capsular release and manipulation under general anesthesia for adhesive capsulitis. Six hours postoperatively, she suffered an anterior glenohumeral joint dislocation with passive forward flexion while working physical therapy. Postoperative workup revealed pseudocholinesterase deficiency. Pseudocholinesterase deficiency may increase the risk of atraumatic in immediate postoperative period. Caution should be taken concerning early therapy these...
Background: Concomitant arthroscopic rotator cuff repair (ARCR) and microfracture (MFX) for glenoid articular cartilage lesions among active-duty servicemembers yields lower return-to-duty rates than ARCR alone; however, there is no existing comparison with outcomes after MFX alone to elucidate where these discrepancies arise. Purpose: To compare postoperative without ARCR. Study Design: Cohort study; Level of evidence, 3. Methods: Active-duty 18 50 years age who underwent either...
Study Design. Retrospective database analysis. Objective. To determine whether any associations exist between the use of preoperative epidural steroid injections (ESIs) and postoperative complications following cervical disc replacement (CDR). Summary Background Data. Preoperative ESIs are a commonly used modality for patients with spine pathology. Previous studies have demonstrated to be associated higher after anterior discectomy fusion. date, there is little known about impact on outcomes...
Abstract Mutants of the necrotic (nec) gene in Drosophila melanogaster die late pupal stage as pharate adults, or hatch weak, but relatively normal-looking, flies. Adults develop black melanized spots on body and leg joints, abdomen swells with hemolymph, flies within 3 4 days eclosion. The TOLL-mediated immune response to fungal infections is constitutively activated nec mutants pleiotropic phenotypes include melanization cellular necrosis. These changes are consistent activation one more...
Molecular diagnosis using urine is established for many sexually transmitted diseases and increasingly used to diagnose tumours other infectious diseases. Storage of prior analysis, whether due home collection or bio-banking, advocated yet no best practice has emerged. Here, we examined the stability DNA in stored two populations over 28 days.Urine from 40 (20 male) healthy volunteers populations, Italy Zambia, was at four different temperatures (RT, 4 degrees C, -20 C & -80 C) with without...