A5105771741- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Infectious Diseases and Tuberculosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Diagnosis and treatment of tuberculosis
- Pneumonia and Respiratory Infections
- Obstructive Sleep Apnea Research
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Immunodeficiency and Autoimmune Disorders
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Neuroscience of respiration and sleep
- Diabetes Management and Research
- Diabetes Treatment and Management
- Immune responses and vaccinations
- Essential Oils and Antimicrobial Activity
- IL-33, ST2, and ILC Pathways
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Infectious Diseases and Mycology
- Phytochemistry and Biological Activities
Jamia Hamdard
1996-2024
Bihar Agricultural University
2024
All India Institute of Medical Sciences
2013-2023
Datta Meghe Institute of Medical Sciences
2017-2023
Institute of Molecular Medicine
2017-2023
Jawaharlal Nehru Medical College
2017-2022
National Institute of Ayurveda
2022
Bangalore Diabetes Centre
2020
Guru Jambheshwar University of Science and Technology
2008-2018
Delhi Pharmaceutical Science and Research University
2018
Obstructive sleep apnea is associated with an increased prevalence of the metabolic syndrome and its components. It unclear whether treatment obstructive continuous positive airway pressure (CPAP) would modify these outcomes.In our double-blind, placebo-controlled trial, we randomly assigned patients to undergo 3 months therapeutic CPAP followed by sham CPAP, or vice versa, a washout period 1 month in between. Before after each intervention, obtained measurements anthropometric variables,...
Introduction: Tuberculosis (TB) is a major cause of morbidity and mortality globally. Extrapulmonary TB (EPTB) constitutes about 15%-20% all patients, but accounts for 50% among HIV-coinfected. Confirmation microbial diagnosis EPTB usually challenging.Areas covered: Availability newer imaging modalities like 18FDG-PET-CT PET-MRI has facilitated precise anatomical localization the lesions mapping extent EPTB. The use image- endoscopy-guided invasive diagnostic methods made procurement...
Xpert MTB/RIF is a novel automated molecular diagnostic recently endorsed by the World Health Organization. However, performance-related data from high HIV prevalence settings are limited.The impact of sample-related factors on performance and significance MTB/RIF-positive culture-negative discordance remain unclear.Xpert was evaluated using single archived spot-sputum samples 496 South African patients with suspected TB. Mycobacterium tuberculosis culture positivity phenotypic resistance to...
Extrapulmonary tuberculosis (EPTB) is frequently a diagnostic and therapeutic challenge. It common opportunistic infection in people living with HIV/AIDS other immunocompromised states such as diabetes mellitus malnutrition. There paucity of data from clinical trials EPTB most the information regarding diagnosis management extrapolated pulmonary TB. Further, there are no formal national or international guidelines on EPTB. To address these concerns, Indian were developed under auspices...
Interstitial lung disease (ILD) is a heterogeneous group of acute and chronic inflammatory fibrotic diseases. Existing ILD registries have had variable findings. Little known about the clinical profile ILDs in India.To characterize new-onset India by creating prospective using multidisciplinary discussion (MDD) to validate diagnoses.Adult patients Indian origin living with (27 centers, 19 cities, March 2012-June 2015) without malignancy or infection were included. All connective tissue (CTD)...
It is being realized that identification of subgroups within normal controls corresponding to contrasting disease susceptibility likely lead more effective predictive marker discovery. We have previously used the Ayurvedic concept Prakriti , which relates phenotypic differences in individuals, including response external environment as well diseases, explore molecular between three types: Vata, Pitta, and Kapha . EGLN1 was one among 251 differentially expressed genes types. In present study,...
Pulmonary tuberculosis still remains a major communicable disease worldwide. In 2013, 9 million people developed TB and 1.5 died from the disease. India constitutes 24% of total burden. Early detection cases is key to successful treatment reduction transmission. Xpert MTB/RIF, an automated cartridge-based molecular technique detects Mycobacterium rifampicin resistance within two hours has been endorsed by WHO for rapid diagnosis TB. Our study first with large sample size evaluate performance...
Background The accurate diagnosis of TB in HIV-infected patients, particularly with advanced immunosuppression, is difficult. Recent studies indicate that a lipoarabinomannan (LAM) assay (Clearview-TB®-ELISA) may have some utility for the patients; however, precise subgroup benefit from this technology requires clarification. LAM sputum samples has, hitherto, not been evaluated. Methods was measured and urine obtained 500 consecutively recruited ambulant suspected TB, 2 primary care clinics...
Background There are currently two tests for diagnosing latent tuberculosis infection (LTBI); TST and IGRA. However, it is still unclear that which one of these performs better in high TB-burden settings. Methods 1511 household contacts pulmonary TB patients were enrolled to compare the performance IGRA LTBI. At baseline all participant underwent testing [QuantiFERON-TB® Gold In-tube (QFT-GIT) assay] [2 tuberculin unit (TU), purified protein derivative (PPD), RT23, Staten Serum Institute...
Prolonged treatment of tuberculosis (TB) often leads to poor compliance, default and relapse, converting primary TB patients into category II (Cat IITB) cases, many whom may convert multi-drug resistant (MDR-TB). We have evaluated the immunotherapeutic potential Mycobacterium indicus pranii (MIP) as an adjunct Anti-Tubercular Treatment (ATT) in Cat pulmonary (PTB) a prospective, randomized, double blind, placebo controlled, multicentric clinical trial. 890 sputum smear positive PTB were...
Evidence on the comparative performance of purified protein derivative tuberculin skin tests (TST) and interferon-gamma release assays (IGRA) for predicting incident active tuberculosis (TB) remains conflicting. We conducted an individual participant data meta-analysis to directly compare predictive TB disease between TST IGRA inform policy.
The inadequacy of effector T-cell response in containment tubercle bacilli is believed to result the development disseminated forms tuberculosis (TB), such as miliary (MTB). Regulatory T cells (Treg) plausibly play a critical role immunopathogenesis TB by suppression immune against Mycobacterium at pathologic site(s). To understand Treg tuberculosis, we studied frequency and function derived from local disease site specimens (LDSS) patients with pleural effusion MTB clinical models contained...
Background The objectives of the study were to compare performance line probe assay (GenoType MTBDRplus) with solid culture method for an early diagnosis multidrug resistant tuberculosis (MDR-TB), and mutation patterns associated rpoB, katG inhA genes at a tertiary care centre in north India. Methods In this cross-sectional study, 269 previously treated sputum-smear acid-fast bacilli (AFB) positive MDR-TB suspects enrolled from January September 2012 All India Institute Medical Sciences...