A5022234608- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Bioinformatics and Genomic Networks
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Treatment of Major Depression
- Pesticide Exposure and Toxicity
- Adipose Tissue and Metabolism
- Single-cell and spatial transcriptomics
- Mental Health Research Topics
- Computational Drug Discovery Methods
- Genetics and Neurodevelopmental Disorders
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Genetic Associations and Epidemiology
- Biomedical Text Mining and Ontologies
- Pancreatic and Hepatic Oncology Research
- Cell Image Analysis Techniques
- Retinoids in leukemia and cellular processes
- Cannabis and Cannabinoid Research
- RNA regulation and disease
- Phagocytosis and Immune Regulation
- Machine Learning in Bioinformatics
- Memory and Neural Mechanisms
University of Wyoming
2023-2025
University of Toledo
2020-2025
Wyoming Department of Education
2024-2025
Centre for Addiction and Mental Health
2017-2021
Mental Health Research Institute
2020
Mental Health Research Canada
2019
University of Toronto
2018-2019
Nil Ratan Sircar Medical College and Hospital
2018
Medical College and Hospital, Kolkata
2018
The Graduate University for Advanced Studies, SOKENDAI
2011-2014
Despite available clinical management strategies, chronic kidney disease (CKD) is associated with severe morbidity and mortality worldwide, which beckons new solutions. Host-microbial interactions a depletion of Faecalibacterium prausnitzii in CKD are reported. However, the mechanisms about if how F can be used as probiotic to treat remains unknown.We evaluated microbial compositions 2 independent populations for any potential probiotic. Next, we investigated supplementation such mouse model...
A survey was conducted in 47 locations nine cotton-growing states of India to identify the composition mealybug species occurring on cotton. Results taxonomic study showed that two species, solenopsis mealybug, Phenacoccus (Tinsley), and pink hibiscus Maconellicoccus hirsutus (Green), were found infest cotton plants from all growing country. However, P. be predominant comprising 95% samples examined. solenopsis, which hitherto not reported occur India, now appears widespread almost is an...
It is being realized that identification of subgroups within normal controls corresponding to contrasting disease susceptibility likely lead more effective predictive marker discovery. We have previously used the Ayurvedic concept Prakriti , which relates phenotypic differences in individuals, including response external environment as well diseases, explore molecular between three types: Vata, Pitta, and Kapha . EGLN1 was one among 251 differentially expressed genes types. In present study,...
Several types of mood disorders lie along a continuum, with nebulous boundaries between them. Understanding the mechanisms that contribute to disorder complexity is critical for effective treatment. However, present treatments are largely centered around neurotransmission and receptor-based hypotheses, which, given high instance treatment resistance, fail adequately explain complexities disorders. In this opinion piece, based on our recent results, we propose ribosome hypothesis We suggest...
Neurodevelopmental disorders (NDDs) are a category of pervasive the developing nervous system with few or no recognized biomarkers. A significant portion risk for NDDs, including attention deficit hyperactivity disorder (ADHD), is contributed by environment, and exposure to pyrethroid pesticides during pregnancy has been identified as potential factor NDD in unborn child. We recently showed that low-dose developmental pesticide deltamethrin mice causes male-biased changes ADHD- NDD-relevant...
Pancreatic cancer remains one of the most difficult malignancies to treat. Minimal improvements in patient outcomes and persistently abysmal survival rates underscore great need for new treatment strategies. Currently, there is intense interest therapeutic strategies that target tyrosine protein kinases. Here, we employed kinome arrays bioinformatic pipelines capable identifying differentially active kinases different patient-derived pancreatic ductal adenocarcinoma (PDAC) cell lines...
Abstract Psychological loss is a common experience that erodes well-being and negatively impacts quality of life. The molecular underpinnings are poorly understood. Here, we investigate the mechanisms using an environmental enrichment removal (ER) paradigm in male rats. basolateral amygdala (BLA) was identified as region interest, demonstrating differential Fos responsivity to ER having established role stress processing adaptation. A comprehensive multi-omics investigation BLA, spanning...
To better understand serotonin function in the primate brain, we examined mRNA expression patterns of all 13 members receptor (5HTR) family, by situ hybridization (ISH) and distribution serotonergic terminations transporter (SERT) protein immunohistochemical analysis. Ten 5HTRs showed significant expressions marmoset brain. Our study shows several new features organization systems (1) The thalamus expressed only a limited number subtypes compared with cortex, hippocampus, other subcortical...
Abstract The common molecular mechanisms underlying psychiatric disorders are not well understood. Prior attempts to assess the pathological responsible for have been limited by biased selection of comparable disorders, datasets/cohort availability, and challenges with data normalization. Here, using DisGeNET, a gene-disease associations database, we sought expand such investigations in terms number types diseases. In top-down manner, analyzed an unbiased cluster 36 comorbid conditions at...
Abstract Cell-specific molecular investigations of the human brain are essential for understanding neurobiology diseases, but hindered by postmortem conditions and technical challenges. To address these issues we developed a multi-label fluorescence in situ hybridization protocol novel optical filter device to identify cell types control tissue autofluorescence. We show that methods can be used with laser-capture microdissection cell-specific analysis.
Abstract The underlying biological mechanisms that contribute to the heterogeneity of major depressive disorder (MDD) presentation remain poorly understood, highlighting need for a conceptual framework can explain this variability and bridge gap between animal models clinical endpoints. Here, we hypothesize comparative analysis molecular data from different experimental systems chronic stress, MDD has potential provide insight into these address gap. Thus, compared transcriptomic profiles...
Abstract Background In silico data exploration is a key first step of exploring research question. There are many publicly available databases and tools that offer appealing features to help with such task. However, applications lack exposure or constrained unfriendly outdated user interfaces. Thus, it follows there resources relevant investigation medical disorders underutilized. Results We developed an R Shiny web application, called Kaleidoscope, address this challenge. The application...
A group of 5 genes, OCC1, testican-1, testican-2, 5-HT1B, and 5-HT2A, are selectively expressed in layer 4 (4C Brodmann) striate cortex (visual area V1) both Old World macaques New marmoset monkeys. The expression these genes is activity dependent, as reduced after blocking retinal activity. Surprisingly, the pronounced pattern has not been found rodents or carnivores. Thus, may be highly V1 some but perhaps all primates. Here, we compared gene members 3 major branches primate evolution:...
Omics studies use large-scale high-throughput data to explain changes underlying different traits or conditions. However, omics analysis often results in long lists of pathways that are difficult interpret. Therefore, it is interest describe a tool named PAVER (Pathway Analysis Visualization with Embedding Representations) for large scale genomic analysis. curates similar into groups, identifies the pathway most representative each group, and provides publication-ready intuitive...
Neurodevelopmental disorders (NDDs) are a category of pervasive the developing nervous system with few or no recognized biomarkers. A significant portion risk for NDDs, including attention deficit hyperactivity disorder (ADHD), is contributed by environment, and exposure to pyrethroid pesticides during pregnancy has been identified as potential factor NDD in unborn child. We recently showed that low-dose developmental pesticide deltamethrin mice causes male-biased changes ADHD- NDD-relevant...