A5060844656- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Radiopharmaceutical Chemistry and Applications
- Wnt/β-catenin signaling in development and cancer
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Immune Cell Function and Interaction
- Genetic factors in colorectal cancer
- Medical Imaging Techniques and Applications
- DNA Repair Mechanisms
- Psoriasis: Treatment and Pathogenesis
- Cytokine Signaling Pathways and Interactions
- Diabetes and associated disorders
- Cancer-related Molecular Pathways
- T-cell and B-cell Immunology
- PARP inhibition in cancer therapy
- Landslides and related hazards
- Cell death mechanisms and regulation
- Natural product bioactivities and synthesis
- Immunodeficiency and Autoimmune Disorders
- Cancer-related gene regulation
- Macrophage Migration Inhibitory Factor
Second Affiliated Hospital of Xi'an Jiaotong University
2014-2024
Xian Yang Central Hospital
2024
UNSW Sydney
2024
Zhengzhou University of Light Industry
2023
Shenyang Sport University
2023
Hebei Medical University
2023
University of Iowa
2023
Development Research Center
2023
Sun Yat-sen University
2013-2020
Chengdu University of Technology
2020
The coronavirus disease 2019 (COVID-19) was first reported in Wuhan, China and rapidly spread other countries December 2019. infected patients presented with fever, respiratory symptoms, sometimes digestive systemic manifestations, some progressed a severe acute syndrome or even death. Associated symptoms were frequently observed the patients, an unknown significance mechanism. ACE2, as major known functional receptor of novel (2019-nCoV) attracted our attention. We collected clinical data...
Background: Hexavalent chromium [Cr(VI)] is an occupational carcinogen that can cause lung and nasal cancers, but its association with mortality incidence in many other cancers unclear. Objectives: In this meta-analysis, we aimed to evaluate the relationship between exposure Cr(VI) of human cancers. Methods: We performed a search literature extracted standardized ratios (SMRs), (SIRs), their corresponding 95% confidence intervals (CIs), estimate risk values. Subgroup analyses were conducted...
Despite available clinical management strategies, chronic kidney disease (CKD) is associated with severe morbidity and mortality worldwide, which beckons new solutions. Host-microbial interactions a depletion of Faecalibacterium prausnitzii in CKD are reported. However, the mechanisms about if how F can be used as probiotic to treat remains unknown.We evaluated microbial compositions 2 independent populations for any potential probiotic. Next, we investigated supplementation such mouse model...
Breast cancer is the most common in women worldwide. The association between body mass index (BMI) and breast risk has been paid more attention past few years, but findings are still controversial. To obtain a reliable conclusion, we performed dose-response meta-analysis on 12 prospective cohort studies comprising 22,728,674 participants.Linear nonlinear trend analyses were conducted to explore relationship BMI risk. summary relative (SRR) 95% confidence intervals (CIs) used evaluate...
203Pb and 212Pb have emerged as promising theranostic isotopes for image-guided α-particle radionuclide therapy cancers. Here, we report a cyclen-based Pb specific chelator (PSC) that is conjugated to tyr3-octreotide via PEG2 linker (PSC-PEG-T) targeting somatostatin receptor subtype 2 (SSTR2). PSC-PEG-T could be labeled efficiently purified at 25 °C also 212Bi 80 °C. Efficient radiolabeling of mixed in was observed Post radiolabeling, stable Pb(II) Bi(III) radiometal complexes saline were...
Sanguisorba officinalis L. radix is a widely used herb called DiYu (DY) in China and has an extensive range of bioactivities, including anti-cancer, anti-inflammatory, anti-oxidative activities. However, there little evidence to support its anti-cancer effects against colorectal cancer (CRC). The first-line chemotherapeutic agent 5-fluorouracil (5-FU) treat CRC, but efficiency hampered by acquired drug resistance. This study found that water extract DY exerted anti-proliferative two CRC cell...
Abstract The prognosis of hepatocellular carcinoma (HCC) is poor because high incidence recurrence and metastasis. JAK/STAT signalling pathway regulates cell proliferation, apoptosis, differentiation migration epithelial‐mesenchymal transition (EMT) also considered to contribute invasion metastasis epithelial malignant tumours. Scutellarin an active component found in many traditional Chinese herbs has been regularly used anti‐inflammatory antitumour medicine. This study aimed identify the...
DNA polymerases are responsible for ensuring stability of the genome and avoiding genotoxicity caused by a variety factors during replication. Consequently, these proteins have been associated with an increased cancer risk. polymerase kappa (POLK) is specialized involved in translesion synthesis (TLS) that allows over damaged DNA. Recently, some studies investigated relationships between POLK polymorphisms risk, but role genetic variants breast (BC) remains to be defined. In this study, we...
To determine the optimal dexmedetomidine dose for hemodynamic stability and recovery quality in modified electroconvulsive therapy (MECT). In this randomized trial, 252 patients receiving MECT were allocated to six groups (placebo, D1-D5; 42/group). Groups D1-D5 received (0.2-1.0 μg/kg) 10 min pre-anesthesia, while controls saline. Hemodynamic parameters heart rate (HR), mean arterial pressure (MAP), seizure duration, propofol requirements, times, adverse events analyzed. Doses ≥ 0.4 μg/kg...
MicroRNAs (miRNAs) play an important role as regulators of tumor suppressors and oncogenes in cancer-related processes. Single nucleotide polymorphisms (SNPs) miRNAs have been shown to be relevant various different cancers, including breast cancer (BC). The aim this study was estimate the associations between miRNA-related gene (miR-196a2, miR-499, miR-608) risk BC a Chinese population. Gene were analyzed 1143 subjects (controls = 583; 560). 3 SNPs genotyped using Sequenom Mass-ARRAY...
Abstract The majority of the human genome encodes long noncoding RNA (lncRNA) genes, critical regulators various cellular processes, which largely outnumber protein-coding genes. However, lncRNA-involved fusions have not been surveyed and characterized yet. Here, we present a systematic study lncRNA fusion landscape across cancer types identify >30 000 high-confidence tumor-specific (using 8284 tumor 6946 normal samples). Fusions positively correlated with DNA damage stemness were...
Abstract c‐Myc overexpression has been implicated in several malignancies including gastric cancer. Here, we report that acidified bile acids enhance tumor progression and telomerase activity cancer via activation both vivo vitro. mRNA protein levels were assessed ten primary five local recurrent samples by quantitative real‐time polymerase chain reaction western blotting analysis. The cell line MGC803 was exposed to salts (100 μ mol/L glycochenodeoxycholic acid deoxycholic acid) an medium...
The UGT1A1*28 polymorphism was suggested to be significantly connected with irinotecan-induced toxicity and response chemotherapy.However, the results of previous studies are controversial.Hence we carried out a meta-analysis investigate effect on severe diarrhea, neutropenia, patients who had undergone irinotecan-based chemotherapy.The PubMed, Web Science, Wanfang, CNKI databases were searched for clinical trials assessing association combined odds ratios (ORs) 95% confidence intervals...
Background: PD-L1 has been reported to be expressed in diverse human malignancies. However, the prognostic value of digestive system cancers remains inconclusive. Therefore, we conducted this meta-analysis evaluate impact expression cancers. Materials and methods: We searched PubMed, Embase, Chinese National Knowledge Infrastructure for publications concerning Correlations level with overall survival (OS), disease-free (DFS), recurrence-free (RFS) were analyzed. Results: Finally, 32 studies...