A5036723838- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Nicotinic Acetylcholine Receptors Study
- Diet and metabolism studies
- Receptor Mechanisms and Signaling
- Gastrointestinal motility and disorders
- Neuroscience and Neuropharmacology Research
- Sex and Gender in Healthcare
- Diet, Metabolism, and Disease
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Diabetes and associated disorders
- Genetics and Neurodevelopmental Disorders
- Menopause: Health Impacts and Treatments
- Bipolar Disorder and Treatment
University of Toledo
2022-2024
Despite available clinical management strategies, chronic kidney disease (CKD) is associated with severe morbidity and mortality worldwide, which beckons new solutions. Host-microbial interactions a depletion of Faecalibacterium prausnitzii in CKD are reported. However, the mechanisms about if how F can be used as probiotic to treat remains unknown.We evaluated microbial compositions 2 independent populations for any potential probiotic. Next, we investigated supplementation such mouse model...
Abstract The underlying biological mechanisms that contribute to the heterogeneity of major depressive disorder (MDD) presentation remain poorly understood, highlighting need for a conceptual framework can explain this variability and bridge gap between animal models clinical endpoints. Here, we hypothesize comparative analysis molecular data from different experimental systems chronic stress, MDD has potential provide insight into these address gap. Thus, compared transcriptomic profiles...
Psychiatric disorders like major depressive disorder (MDD), schizophrenia (SCZ), and bipolar (BPD), represent a significant global public health concern. Sex differences in the prevalence presentation of psychiatric disorders, association diagnosis with increased risk suicide, are well-established. However, neurobiology underlying these features disease not well understood. Dysfunction orbitofrontal cortex (OFC), brain region responsible for decision-making sensory processing, has been...
A growing number of studies implicate a key role for metabolic processes in psychiatric disorders. Recent suggest that ketogenic diet may be therapeutically effective subgroups people with schizophrenia (SCZ), bipolar disorder (BPD) and possibly major depressive (MDD). Despite this promise, there is currently limited information regarding brain energy metabolism pathways across these disorders, limiting our understanding how are altered who benefit from diets. We conducted gene expression...
The amygdala, crucial for mood, anxiety, fear, and reward regulation, shows neuroanatomical molecular divergence in psychiatric disorders like schizophrenia, bipolar disorder major depression. This region is also emerging as an important regulator of metabolic immune pathways. goal this study to address the paucity studies human amygdala. We hypothesize that diagnosis-specific gene expression alterations contribute unique pathophysiological profiles these disorders.
Abstract The underlying biological mechanisms that contribute to the heterogeneity of major depressive disorder (MDD) presentation remain poorly understood, highlighting need for a conceptual framework can explain this variability and bridge gap between animal models clinical endpoints. Here, we hypothesize comparative analysis molecular data from different experimental systems chronic stress MDD has potential provide insight into these address gap. Thus, compared transcriptomic profiles...