A5100457422- Cancer-related molecular mechanisms research
- interferon and immune responses
- HIV Research and Treatment
- RNA modifications and cancer
- MicroRNA in disease regulation
- HIV/AIDS drug development and treatment
- Mesenchymal stem cell research
- Chemokine receptors and signaling
- Circular RNAs in diseases
- HIV/AIDS Research and Interventions
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Sarcoma Diagnosis and Treatment
- Psoriasis: Treatment and Pathogenesis
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Atherosclerosis and Cardiovascular Diseases
- Pregnancy and preeclampsia studies
- Gut microbiota and health
- Cancer-related gene regulation
- Reproductive System and Pregnancy
- Signaling Pathways in Disease
- Selenium in Biological Systems
- Kruppel-like factors research
- Immunotherapy and Immune Responses
First Affiliated Hospital of Xi'an Jiaotong University
2022-2025
Ocean University of China
2025
Hebei Provincial Center for Disease Control and Prevention
2019-2025
Huazhong Agricultural University
2022-2024
Gansu University of Traditional Chinese Medicine
2024
Liaoning University of Traditional Chinese Medicine
2024
Shandong University
2004-2024
Center for Cancer Research
2024
Zhejiang Lab
2024
Zhejiang University Medical College Affiliated Stomatological Hospital
2024
Abstract The objective of this study is to evaluate the effects tannic acid (TA) derived from gallnut supplementation on growth performance and health status weaned piglets. A total 432 weanling piglets (7.05 ± 1.05 kg) were randomly allocated into 4 treatment groups with 6 replicates 18 pigs/pen. Piglets fed either a basal diet (CON), or diets supplemented 1.5 kg/t TA, 3.0 1.8 zinc oxide (ZnO) for 21 days. results showed that, compared CON, dietary TA did not affect ( p > 0.05) serum...
Abstract The mechanism by which osteosarcomas metastasize is elusive, and challenges remain regarding its treatment with modalities including immunotherapy. CXCL12 deeply involved in the process of tumor metastasis T-cell homing, driven a chemokine gradient, but healthy bones are supposed to preferentially express CXCL12. Here, we show for first time that epigenetically downregulate expression via DNA methyltransferase 1 (DNMT1) consequently acquire ability impair cytotoxic homing site....
Dysregulation of microRNA expression levels is closely associated with a variety human diseases, and their rapid sensitive quantification essential to clinical diagnosis therapy. Because poor sensitivity, conventional methods are unable detect low-abundance microRNAs. Alternatively, nucleic acid amplification approaches have been introduced improve the detection but most them involve complicated probe design time-consuming procedures. Herein, we report simple, rapid, fluorescent method for...
Activation of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome received substantial attention recently in inflammatory diseases. Macrophages contribute to allergic inflammation asthma. The present study was aimed investigate the effect NLRP3 on polarization macrophages. We utilized human primary monocytes and monocyte-derived macrophages expression components (NLRP3, apoptosis-associated specklike protein, caspase-1) its downstream cytokine interleukin-1β...
Bone morphogenetic proteins (BMPs) are a family of potent, multifunctional growth factors belonging to transforming factor-β (TGF-β). They highly conservative in structures. Over 20 members BMPs with varying functions such as embryogenesis, skeletal formation, hematopoiesis and neurogenesis have been identified human body. unique that can induce the formation bone tissue individually. differentiation marrow mesenchymal stem cells into osteoblastic lineage promote proliferation osteoblasts...
Noncoding RNAs (ncRNAs), primarily microRNAs and long ncRNAs, play important roles in lung cancer. However, the role of ncRNA (lncRNA)-X-inactive specific transcript (XIST) non-small-cell cancer (NSCLC) is unclear. The purpose this study was to explore biologic function potential mechanism XIST NSCLC progression.XIST, miR-137, Notch-1 expression were detected by quantitative real-time PCR (qRT-PCR). Levels proliferation- epithelial-mesenchymal transition (EMT)-related proteins assessed...
Psoriasis is one of several chronic inflammatory skin diseases with a high rate recurrence, and its pathogenesis remains unclear. Nicotinamide mononucleotide (NMN), as an important precursor nicotinamide adenine dinucleotide (NAD+), has been reported to be promising agent in treating various diseases, positive effects including those induced via anti-inflammatory antioxidant properties. For this reason, we have aimed explore the possible role NMN treatment psoriasis. models were constructed...
Although many studies have investigated the association between psoriasis and chronic obstructive pulmonary disease (COPD), causal relationship COPD is still unknown.
With increasingly serious eye exposure to light stresses, such as light-emitting diodes, computers, and widescreen mobile phones, efficient natural compounds for preventing visible light-induced retinal damages are becoming compelling needs in the modern society. Fucoxanthin, main absorption system marine algae, may possess an outstanding bioactivity vision protection because of its filtration blue excellent antioxidative activity. In this work, both vitro vivo simulated damage models were...
Behavior alterations in fibroblast-like synoviocytes (FLS) contribute to a pivotal role pathogenesis of rheumatoid arthritis (RA). MiRNAs are closely involved variety pathologic conditions. In the present study, we aimed screen for aberrant expression miRNAs (RA-FLS) further identify altered miR-26a-5p RA-FLS and investigate RA. The was screened by microarray analysis confirmed quantitative real time PCR. effect on proliferation, cell cycle, apoptosis, invasion were studied. verification...
Atrial natriuretic peptide (ANP) is an important hormone in cardiovascular biology. It activated by the protease corin. In pregnancy, ANP and corin promote uterine spiral artery remodeling, but underlying mechanism remains unknown. Here we report function decidualization TNF-related apoptosis-inducing ligand–dependent (TRAIL-dependent) death arterial smooth muscle cells (SMCs) endothelial (ECs). ANP- or corin-deficient mice, markers TRAIL expression were decreased, whereas cultured human...
Background Constipation is common gastrointestinal disorder with high prevalence and recurrence, making people suffering. However, the treatment for constipation remains ineffectual. We aimed to study effects mechanisms of postbiotic hawthorn-probiotic on loperamide modeled old KM mice. Methods Constipated mice were grouped treated 10% lactulose (Y), hawthorn group (S), probiotic (F) (FS). Fecal changes observed. AQP3 Enac-γ measured by RT-qPCR Western blotting, intestinal barrier...
Brodalumab, a humanized monoclonal antibody that targets the interleukin-17 receptor A, is primarily used to manage moderate-to-severe plaque psoriasis. Although it has demonstrated favorable efficacy and safety in clinical trials, strict inclusion exclusion criteria may not fully reflect its profile real-world settings. As use becomes more widespread practice, understanding applications crucial.This study employed disproportionality analysis assess of brodalumab by examining all adverse...
Introduction Lyme arthritis (LA) is a chronic inflammatory joint disease caused by Borrelia burgdorferi infection, with approximately 10-20% of patients developing antibiotic resistance. Macrophages in the synovial microenvironment play crucial role progression, but their precise regulatory mechanisms remain unclear. Methods We analyzed scRNA-seq data (GSE233850) from LA mouse tissue and integrated transcriptomic models GSE125503 dataset. Cell clustering, differential gene analysis, GO KEGG...
HIV-1 protease (PR)-reverse transcriptase (RT) inhibitors as national free antiretroviral drugs have been used for 20 years. Integrase strand transfer (INSTIs) conditionally a component of HIV/AIDS treatment regimens in recent However, the systematic investigation on changes primary drug resistance (PDR) Hebei province, China was limited. A continuous cross-sectional PDR conducted, integrating detection genotype, molecular network, and statistical analysis. The overall prevalence 8.3%, with...