A5090966085- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Autophagy in Disease and Therapy
- Fibroblast Growth Factor Research
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- RNA modifications and cancer
- Inflammasome and immune disorders
- Urticaria and Related Conditions
- Mast cells and histamine
- Epilepsy research and treatment
- Fetal and Pediatric Neurological Disorders
- Dialysis and Renal Disease Management
- Cytomegalovirus and herpesvirus research
- Cancer, Hypoxia, and Metabolism
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neonatal Health and Biochemistry
- Osteoarthritis Treatment and Mechanisms
- Gout, Hyperuricemia, Uric Acid
- Systemic Lupus Erythematosus Research
- Natural product bioactivities and synthesis
- Immune Cell Function and Interaction
- Nitric Oxide and Endothelin Effects
- bioluminescence and chemiluminescence research
Hebei Provincial Center for Disease Control and Prevention
2017-2025
Shenyang Anorectal Hospital
2024-2025
Nanjing Drum Tower Hospital
2022-2025
Hunan Provincial Center for Disease Control and Prevention
2024
Ningbo Medical Center Lihuili Hospital
2021-2024
Ningbo University
2023-2024
Yancheng Second People's Hospital
2020-2024
Yangzhou University
2024
Guangdong Medical College
2011-2024
Center for Food Safety and Applied Nutrition
2024
Background: Imbalanced cellular immunity is critical to the pathogenesis of systemic lupus erythematosus (SLE). Recently, autophagy has emerged as a key homeostatic mechanism in T lymphocytes. This study was conducted explore impact on Th17/ regulatory (Treg) immune imbalance SLE. Methods: Peripheral Th17 and Treg cells from newly diagnosed patients with SLE healthy controls were detected by flow cytometry. Additionally, effects chloroquine (CQ) autophagic inhibition Th17/Treg response...
Macroautophagy/autophagy activation in renal tubular epithelial cells protects against acute kidney injury (AKI). However, the role of immune cell autophagy, such as that involving macrophages, AKI remains unclear. In this study, we discovered macrophage autophagy was an adaptive response during mice with macrophage-specific deficiency (atg5−/−) exhibited higher serum creatinine, more severe tubule injury, increased infiltration ADGRE1/F4/80+ and elevated expression inflammatory factors...
Lupus nephritis (LN) is a major complication and cause of death among patients with SLE. This research used in vivo vitro experiments to explore the therapeutic potential metformin kidney injury from LN-induced inflammation.In study, 8-week-old MRL/MpJ-Faslpr/J (MRL/lpr) mice were randomly divided into two groups (n=12 each): daily administration 0.3 mg/mL drinking water control (water only). Body weight urinary samples measured biweekly. Mice sacrificed after 8-week treatment harvest serum,...
Fibroblast growth factor-18 (FGF18) has diverse organ development and damage repair roles. However, its role in cardiac homeostasis following hypertrophic stimulation remains unknown. Here we investigate the regulation function of FGF18 pressure overload (PO)-induced pathological hypertrophy. heterozygous (Fgf18+/-) inducible cardiomyocyte-specific knockout (Fgf18-CKO) male mice exposed to transverse aortic constriction (TAC) demonstrate exacerbated hypertrophy with increased oxidative...
Peritoneal dialysis is a widely used method for treating kidney failure. However, over time, the peritoneal structure and function can deteriorate, leading to failure of this therapy. This deterioration primarily caused by infectious sterile inflammation. Sterile inflammation, which inflammation without infection, particularly concerning as it be subtle often goes unnoticed. The onset involves various pathological processes. cells detect signals that promote release substances attract immune...
Autoantibody and inflammatory cytokines play crucial roles in the development of systemic lupus erythematosus (SLE); however, regulation their production warrants further investigation. This study aimed to investigate role basophil activation SLE based on studies patients with spontaneous lupus-prone MRL-lpr/lpr mice.The phenotypes peripheral basophils autoantibody interleukin (IL)-17 were determined by flow cytometry enzyme-linked immunosorbent assay, also correlations investigated...
Dysregulation of autophagy-mediated podocyte homeostasis is proposed to play a role in idiopathic membranous nephropathy (IMN). In the present study, autophagic activity and lysosomal alterations were investigated podocytes IMN patients cultured exposed sublytic terminal complement complex, C5b-9. C5b-9 upregulated number LC3 positive puncta expression p62 patient injuried model. The turnover LC3-II was not influenced, although BECN1 level after exposure also caused significant increase...
Acute liver injury (ALI), often caused by viruses, alcohol, drugs, etc., is one of the most common clinical diseases. Although pyroptosis plays an important role in ALI, there still a lack effective drugs related to this mechanism. Here, we show that phenethyl isothiocyanate (PEITC), natural compound present cruciferous vegetables, can significantly alleviate concanavalin A (ConA)-induced inflammatory damage and carbon tetrachloride (CCl 4 )-induced chemical dose-dependent manner. PEITC...
HIV-1 protease (PR)-reverse transcriptase (RT) inhibitors as national free antiretroviral drugs have been used for 20 years. Integrase strand transfer (INSTIs) conditionally a component of HIV/AIDS treatment regimens in recent However, the systematic investigation on changes primary drug resistance (PDR) Hebei province, China was limited. A continuous cross-sectional PDR conducted, integrating detection genotype, molecular network, and statistical analysis. The overall prevalence 8.3%, with...
Introduction: Drug-induced liver injury (DILI) represents a distinct form of hepatic damage resulting from exposure to pharmacological agents. The pathological mechanisms underlying DILI are multifaceted and remain incompletely elucidated. However, emerging evidence suggests that cell pyroptosis, programmed death associated with inflammation, may serve as common mechanistic pathway in pathogenesis. Methods: To investigate the role pyroptosis DILI, we established murine model using triptolide...
Baicalin is the major component found in Scutellaria baicalensis root, a widely used herb traditional Chinese medicine, which exhibits strong anti-inflammatory, anti-viral and anti-tumor activities. The present work was devoted to elucidate molecular cellular mechanisms underlying protective effects of against diabetes-induced oxidative damage, inflammation endothelial dysfunction. Diabetic mice, induced by streptozotocin (STZ), were treated with intraperitoneal injections. Human umbilical...
Abstract Background Hydroxychloroquine (HCQ) has been recommended as a basic treatment for lupus nephritis (LN) during this decade based on its ability to improve LN-related renal immune-mediated inflammatory lesions. As classical lysosomal inhibitor, HCQ may inhibit degradation and disrupt protective autophagy in proximal tubular epithelial cells (PTECs). Therefore, the final effects of LN need be clarified. Method was administered spontaneous female MRL/lpr mice with severe proteinuria...
Homosexual transmission has contributed greatly to the current HIV-1 epidemic in Hebei province, China. Dolutegravir (DTG) will be conditionally used as a component of free antiretroviral therapy (ART) according manual for national anti-AIDS treatment drugs (2023 edition) issued by China June 2023. However, genetic characteristics and pretreatment drug resistance (PDR) proteinase inhibitors (PIs), reverse transcriptase (RTs) integrase strand transfer (INSTIs) this population have remained unclear.
FGF13 is an intracellular FGF factor. Its role in cardiomyopathies has been rarely investigated. We revealed that endogenous up-regulated cardiac hypertrophy accompanied by increased nuclear localization. The upregulation of plays a deteriorating both hypertrophic cardiomyocytes and mouse hearts. Mechanistically, directly interacts with p65 its localization sequence co-localizes the nucleus hypertrophy. deficiency inhibits NF-κB activation ISO-treated NRCMs TAC-surgery hearts, whereas...
Protein S-nitrosylation is a reversible protein modification implicated in both physiological and pathophysiological regulation of function. However, the relationship between dysregulated homeostasis diabetic vascular complications remains incompletely understood. Here, we demonstrate that basic fibroblast growth factor (bFGF) key regulatory link inflammation, alleviated endothelial dysfunction angiogenic defects diabetes. Subjecting human umbilical vein cells (HUVECs) to hyperglycemia...
Basophils have been reported to infiltrate skin lesions in various diseases, but not systemic lupus erythematosus (SLE). This study investigated basophil infiltration SLE and its mechanism.Twenty newly diagnosed patients twenty healthy controls were enrolled. Nine underwent biopsies. Flow cytometric analysis the phenotype of peripheral basophils their migration rate toward RANTES MCP-1 analyzed with transwell culture system, also expression these two chemokines tissue...
Our aim was to evaluate the clinical utility of non-invasive prenatal testing for pregnant women with different diagnostic indications.In eight counties and districts Yancheng, we studied 13,149 indications who were offered NIPT fetal screening, including sex chromosomal aneuploidies (SCAs), rare autosomal trisomies (RATs), subchromosomal copy number variations (CNVs). The purpose compare detection positive predictive values (PPVs) use NIPT. results validated by karyotyping, microarray...
Proteinuria is a common feature for almost all glomerular diseases and reflects the severity of lesion. The presence large amount proteins in tubular fluid, however, may also contribute to development RIF (renal interstitial fibrosis). Endocytosis albumin proximal cells triggers PKC (protein kinase C)-dependent generation reactive oxygen species secretion chemokines. As family including 12 isozymes, which isozymes participate still unclear. EMT (epithelial-mesenchymal transdifferentiation)...
<b><i>Background:</i></b> Different methods for intracranial electrode recording have various advantages and disadvantages, controversy exists regarding the complications of stereoelectroencephalography (SEEG) subdural EEG. <b><i>Objective:</i></b> The purpose this study was to determine efficacy safety SEEG by comparing it with <b><i>Methods:</i></b> Data from 100 patients who underwent (<i>n</i> = 48) EEG...