A5100659787- Cardiac Ischemia and Reperfusion
- Autophagy in Disease and Therapy
- Heart Rate Variability and Autonomic Control
- Cardiovascular Function and Risk Factors
- Cancer, Hypoxia, and Metabolism
- Blood Pressure and Hypertension Studies
- Cardiac Valve Diseases and Treatments
- Birth, Development, and Health
- Fibroblast Growth Factor Research
- Traditional Chinese Medicine Analysis
- Animal Nutrition and Physiology
- Kruppel-like factors research
- Metabolism, Diabetes, and Cancer
- Cancer-related molecular mechanisms research
- Nitric Oxide and Endothelin Effects
- Cardiovascular Disease and Adiposity
- MicroRNA in disease regulation
- Eicosanoids and Hypertension Pharmacology
- Antimicrobial Peptides and Activities
- Obesity, Physical Activity, Diet
- Muscle Physiology and Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Cardiovascular and exercise physiology
- Advanced Glycation End Products research
- Cardiac Structural Anomalies and Repair
Shenyang Agricultural University
2025
Qingdao Agricultural University
2019-2024
Xuzhou Medical College
2024
Beijing Tian Tan Hospital
2024
Capital Medical University
2015-2024
Xi'an Jiaotong University
2024
Wuhan Polytechnic University
2019-2023
Yangzhou University
2020-2023
Qingdao Academy of Agricultural Sciences
2023
Third Affiliated Hospital of Sun Yat-sen University
2022
We examined the role of cyclooxygenase-2 (COX-2) in late phase ischemic preconditioning (PC). A total 176 conscious rabbits were used. Ischemic PC (six cycles 4-min coronary occlusions/4-min reperfusions) resulted a rapid increase myocardial COX-2 mRNA levels (+231 ± 64% at 1 h; RNase protection assay) followed 24 h later by an protein expression (+216 79%; Western blotting) and content prostaglandin (PG)E 2 6-keto-PGF 1α (+250 85% +259 107%, respectively; enzyme immunoassay). Administration...
Heat-shock proteins (Hsps) have been shown to render cardioprotection from stress-induced injury; however, little is known about the role of another small heat-shock protein, Hsp20, which regulates activities vasodilation and platelet aggregation, in against ischemia injury. We recently reported that increased expression Hsp20 cardiomyocytes was associated with improved contraction protection beta-agonist-induced apoptosis.To investigate whether overexpression exerts protective effects both...
Evidence suggests Ginsenoside Rd (GSRd), a biologically active extract from the medical plant Panax Ginseng, exerts antioxidant effect, decreasing reactive oxygen species (ROS) formation. Current study determined effect of GSRd on myocardial ischemia/reperfusion (MI/R) injury (a pathological condition where ROS production is significantly increased) and investigated underlying mechanisms. The current utilized an in vivo rat model MI/R vitro neonatal cardiomyocyte (NRC) simulated (SI/R)...
Background and Purpose The authors evaluated the impact of morphologic hemodynamic factors on multiple intracranial aneurysms aimed to identify which parameters can be reliable indexes as one aneurysm ruptured, others did not. Methods Between June 2011 May 2014, 69 patients harboring (69 ruptured 86 unruptured) were analyzed from 3D-digital subtraction angiography (DSA) images computational fluid dynamics (CFD). Morphologic for significance with respect rupture. Receiver operating...
Abstract As a classically known mitogen, fibroblast growth factor 1 (FGF1) has been found to exert other pleiotropic functions such as metabolic regulation and myocardial protection. Here, we show that serum levels of FGF1 were decreased positively correlated with fraction shortening in diabetic cardiomyopathy (DCM) patients, indicating is potential therapeutic target for DCM. We treatment variant (FGF1 ∆HBS ) reduced proliferative potency prevented diabetes-induced cardiac injury remodeling...
Fibroblast growth factor (FGF)-21 is a novel regulator of insulin-independent glucose transport in 3T3-L1 adipocytes and has triglyceride lowering effects rodent models diabetes. In this study, we found that FGF-21 can significantly attenuate ischemia-reperfusion (I/R) induced damage H9c2 cells (rat heart). However, it unclear which signal transduction pathway involved the cardioprotective effect FGF-21. Thus, study was designed to investigate potential mechanism by The results showed...
Abstract Endothelial dysfunction initiates and exacerbates hypertension, atherosclerosis other cardiovascular complications in diabetic mellitus. FGF21 is a hormone that mediates number of beneficial effects relevant to metabolic disorders their associated complications. Nevertheless, it remains unclear as whether ameliorates endothelial dysfunction. Therefore, we investigated the effect on function both type 1 2 diabetes. We found reduced hyperglycemia ameliorated insulin resistance mice,...
Vascular complications of diabetes are a serious challenge in clinical practice, and effective treatments an unmet need. Acidic fibroblast growth factor (aFGF) has potent anti-oxidative properties therefore become research focus for the treatment diabetic vascular complications. However, specific mechanisms by which aFGF regulates these processes remain unclear. The purpose this study was to investigate whether alleviates endothelial dysfunction suppressing mitochondrial oxidative stress. We...
Oxidation is a major cause of meat quality deterioration during broiler production, which leads to undesirable color and impaired water holding capacity (WHC), thereby impacting consumer appeal satisfaction. Chlorogenic acid (CGA), natural phenolic acid, regarded as potential, safer healthier antioxidant improve quality. To investigate the protective effects CGA on oxidatively stressed broilers, 240 one-day-old male Cobb chickens were allocated four treatments: basal diet (control group), +...
In rural areas of China, the prevalence obesity in children has grown continuously, becoming a major problem field pediatrics. The purpose this study is to investigate relationship between Internet use and explore mediating role unhealthy dietary preferences. This empirically tested impact on its mechanism by using survey data Chinese primary secondary school students, OLS model, two-stage least squares method, mediation effect model. provides new evidence that higher when more internet time...
Yan, B, Lai, X, Yi, L, Wang, Y, and Hu, Y. Effects of five-week resistance training in hypoxia on hormones muscle strength. J Strength Cond Res 30(1): 184–193, 2016—The effects different levels systemic hormonal responses, strength, body composition to 5-week were investigated. Twenty-five male subjects randomly assigned into 3 experimental groups that performed 10 sessions (2 per week) barbell back squat (10 repetitions, 5 sets, 70% 1 repetition maximum [RM]) under normoxia (NR, FiO2 = 21%)...
The infarct-sparing effect of the late phase ischemic preconditioning (late PC) lasts for 72 hours. Upregulation both cyclooxygenase-2 (COX-2) and inducible NO synthase (iNOS) has been shown to be essential protection in initial stage PC (24 hours after PC); however, mechanisms underlying final (48 are unknown. Conscious rabbits were preconditioned with six cycles 4-minute coronary occlusion/4-minute reperfusion. At PC, powerful against infarction was associated increased myocardial levels...
Physical exercise has been demonstrated to be neuroprotective in both clinical and laboratory settings. However, the exact mechanism underlying this effect is unclear. Our study aimed investigate whether pre-ischemic treadmill training could serve as a form of ischemic preconditioning rat model undergoing middle cerebral artery occlusion (MCAO). Thirty-six rats were divided into three groups: sham control group, non-exercise with operation group an group. After training, ischemia was induced...
Binge drinking is associated with increased cardiac autophagy, and often triggers heart injury. Given the essential role of autophagy in various diseases, this study was designed to investigate ethanol‐induced injury underlying mechanism. Our showed that ethanol exposure enhanced levels LC3‐II positive puncta promoted cardiomyocyte apoptosis vivo vitro. In addition, we found induced largely via sequential triggering reactive oxygen species (ROS) accumulation, activation c‐Jun NH2‐terminal...
Fusarium verticillioides (formerly F. moniliforme) is suggested as one of the causal agents Pokkah Boeng, a serious disease sugarcane worldwide. Currently, detailed molecular and physiological mechanism pathogenesis unknown. In this study, we focused on cell wall integrity MAPK pathway potential signaling mechanisms associated with Boeng pathogenesis. We identified FvBCK1 gene that encodes MAP kinase homolog determined it not only required for growth, micro- macro-conidia production, but...
Abstract Background The leading cause of end-stage renal disease (ESRD) is diabetic nephropathy (DN). Podocyte damage an early event in the development DN. Currently, there no effective treatment strategy that can slow progression DN or reverse its onset. role mesenchymal stem cells (MSCs) transplantation diabetes and complications has been extensively studied, a major focus. Irbesartan exerts reno-protective effects independent lowering blood pressure, reduce incidence proteinuria rats,...