A5100617690- Mesenchymal stem cell research
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Periodontal Regeneration and Treatments
- Tissue Engineering and Regenerative Medicine
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Oral microbiology and periodontitis research
- Graphene and Nanomaterials Applications
- Nerve injury and regeneration
- Glaucoma and retinal disorders
- Electrospun Nanofibers in Biomedical Applications
- Nanoplatforms for cancer theranostics
- Corneal Surgery and Treatments
- Wound Healing and Treatments
- Ocular Surface and Contact Lens
- Epigenetics and DNA Methylation
- Pluripotent Stem Cells Research
- Advanced biosensing and bioanalysis techniques
- Neuroscience and Neuropharmacology Research
- IL-33, ST2, and ILC Pathways
- 3D Printing in Biomedical Research
- Cancer, Hypoxia, and Metabolism
- Endoplasmic Reticulum Stress and Disease
Guangdong Pharmaceutical University
2013-2025
Tianjin University of Traditional Chinese Medicine
2023-2025
Sichuan University
2019-2025
Air Force Medical University
2015-2024
China University of Geosciences (Beijing)
2024
Union Hospital
2013-2024
Huazhong University of Science and Technology
2012-2024
Southeast University
2012-2024
Jiangnan University
2024
Wuxi Fourth People's Hospital
2023-2024
Abstract Background Periodontitis, which progressively destroys tooth-supporting structures, is one of the most widespread infectious diseases and leading cause tooth loss in adults. Evidence from preclinical trials small-scale pilot clinical studies indicates that stem cells derived periodontal ligament tissues are a promising therapy for regeneration lost/damaged tissue. This study assessed safety feasibility using autologous (PDLSCs) as an adjuvant to grafting materials guided tissue...
Exosomes (EXs) shed by mesenchymal stem cells (MSCs) are potent therapeutic agents that promote wound healing and regeneration, but when used alone in vivo, their potency is diminished rapid clearance bioactivity loss. Inspired the biotin-avidin interaction, we developed a simple yet versatile method for immobilization of MSC-derived EXs (MSC-EXs) into hydrogels achieved sustained release regenerative purposes. First, biotin-modified gelatin methacryloyl (Bio-GelMA) was fabricated grafting...
Carbon dots are promising scaffolds for multifunctional therapeutic systems because of their fluorescence property, good biocompatibility, and low toxicity. In this work, we prepared nitrogen-doped carbon through an aqueous phase strategy using folic acid as precursor. The possess many attractive features including uniform dispersion with size about 9 nm, bright photoluminescence, high photoluminescence quantum yield 23%, toxicity, making them excellent imaging probes biomedical applications.
Abstract As a classically known mitogen, fibroblast growth factor 1 (FGF1) has been found to exert other pleiotropic functions such as metabolic regulation and myocardial protection. Here, we show that serum levels of FGF1 were decreased positively correlated with fraction shortening in diabetic cardiomyopathy (DCM) patients, indicating is potential therapeutic target for DCM. We treatment variant (FGF1 ∆HBS ) reduced proliferative potency prevented diabetes-induced cardiac injury remodeling...
Biomass-derived 2,5-bis(hydroxymethyl)furan (BHMF) has received great attention and interest due to its broad application prospects in polyesters medicine. Over the past decades, catalytic systems including thermocatalytic, biocatalytic, electrocatalytic, photocatalytic hydrogenation of 5-hydroxymethylfurfural (HMF) into BHMF have been developed a extent. To understand present status challenges production, this review systematically evaluates recent findings developments HMF through various...
To evaluate effects of crowding stress on the physiological mechanisms juvenile hybrid sturgeon (♀Acipenser baerii×♂Acipenser schrenckii, 23 ± 1 g body weight), an experiment was assigned to three initial stocking densities in flowing water ponds (LD = 100 and 150 fish/m3; MD 200 250 HD 300 350 fish/m3) for 60 days. Ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) used identify differential metabolites between different densities. The final weight, weight gain...
Abstract The viscoelasticity of mechanically sensitive tissues such as periodontal ligaments (PDLs) is key in maintaining mechanical homeostasis. Unfortunately, PDLs easily lose (e.g., stress relaxation) during periodontitis or dental trauma, which disrupt cell–extracellular matrix (ECM) interactions and accelerates tissue damage. Here, Pluronic F127 diacrylate (F127DA) hydrogels with PDL‐matched relaxation rates high elastic moduli are developed. hydrogel modulated without chemical...
Abstract Macrophages (Mφs) are involved in a variety of physiological and pathological events including wound healing tissue regeneration, which they play both positive negative roles depending on their polarization state. In this study, we investigated the cellular behaviours bone marrow mesenchymal stem cells ( BMMSC s) after incubation different conditioned media CM generated by unpolarized Mφs (M0) or polarized (M1 M2). Mφ was induced stimulation with various cytokines, s were obtained...
Although dental pulp stem cells (DPSCs) isolated from periodontally compromised teeth (P-DPSCs) have been demonstrated to retain pluripotency and regenerative potential, their use as therapeutics remains largely unexplored. In this study, we investigated the proangiogenic effects of extracellular vesicles (EVs) secreted by P-DPSCs using in vitro vivo testing models.Patient-matched DPSCs derived healthy (H-DPSCs) were used control for P-DPSCs. Conditioned media (CMs) H-DPSCs (H-CM P-CM), CMs...
Human umbilical cord-derived mesenchymal stem cells (hUCMSCs) represent potential therapeutic tools for solid tumors. However, there are numerous inconsistent results regarding the effects of hUCMSCs on tumors, and mechanisms underlying this remain poorly understood. The present study further examined controversial issue by analyzing molecular inhibitory proliferation migration human lung cancer A549 cell line hepatocellular carcinoma (HCC) BEL7402 in vitro. Flow cytometric analysis...
Mesenchymal stem cells (MSCs) have been widely used in cytotherapy and tissue engineering due to their immunosuppressive ability regenerative potential. Recently, the immunomodulatory influence of MSCs has gaining increasing attention because functional roles modulating immune responses likely high clinical significance. In this study, we investigated on macrophages (Mφs) in-vitro cell culture systems. Given evidence that aged are functionally compromised, bone marrow-derived (BMSCs)...
Stem cells that have undergone long-term ex vivo expansion are most likely functionally compromised (namely cellular senescence) in terms of their stem cell properties and therapeutic potential. Due to its ability attenuate senescence, melatonin (MLT) has been proposed as an adjuvant protocols, but the mechanism underlying MLT-induced rejuvenation remains largely unknown.Human periodontal ligament (PDLSCs) were isolated cultured for up 15 passages, from passages 2, 7, (P2, P7, P15) used...
Diabetes mellitus is an established risk factor for periodontal disease that can aggravate the severity of inflammation and accelerate destruction. The chronic high glucose condition a hallmark diabetes-related pathogenesis, has been demonstrated to impair osteogenic differentiation ligament stem cells (PDLSCs), leading delayed recovery defects in diabetic patients. Reactive oxygen species (ROS) are small molecules influence cell fate determination direction differentiation. Although...
Stem cell therapy and tissue engineering hold considerable potential for innovative transformative strategies to repair damaged form function. Although many approaches are adopting ex vivo expanded cells transplantation, an alternative is manipulate the biomaterial-host interactions that recruit patients' own stem endogenously regeneration. There several considerations in targeting therapeutically, not least of which biomimetic design extracellular matrix (ECM)-mimicking materials...