A5100612854- Cancer-related molecular mechanisms research
- Kawasaki Disease and Coronary Complications
- Inflammasome and immune disorders
- Circular RNAs in diseases
- RNA Research and Splicing
- MicroRNA in disease regulation
- RNA modifications and cancer
- Pluripotent Stem Cells Research
- Fibroblast Growth Factor Research
- Coronary Artery Anomalies
- Vasculitis and related conditions
- Kruppel-like factors research
- Natural product bioactivities and synthesis
- Renal and related cancers
- Epigenetics and DNA Methylation
- Angiogenesis and VEGF in Cancer
- CRISPR and Genetic Engineering
- Gout, Hyperuricemia, Uric Acid
- Autophagy in Disease and Therapy
- Quantum many-body systems
- Cell Adhesion Molecules Research
- Hedgehog Signaling Pathway Studies
- Atherosclerosis and Cardiovascular Diseases
- Piperaceae Chemical and Biological Studies
- Ginseng Biological Effects and Applications
Wenzhou Medical University
2018-2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2018-2024
Jilin University
2014-2023
Lanzhou University Second Hospital
2023
First Hospital of Jilin University
2014-2023
Zhejiang Institute of Communications
2023
Lanzhou University
2023
Northeast Agricultural University
2020
Second People's Hospital of Yunnan Province
2016
Kunming Medical University
2016
Abstract Kawasaki disease (KD) is the most common cause of pediatric cardiac in developed countries, and can lead to permanent coronary artery damage long term sequelae such as aneurysms. Given prevalence severity KD, further research warranted on its pathophysiology. It known that endothelial cell inflammation are two essential processes resulting dysfunction KD. However, detailed mechanisms largely unknown. In this study, we investigated role pyroptosis setting hypothesized may play a...
Background/Aims: Diabetic non-healing skin ulcers represent a serious challenge in clinical practice, which the hyperglycemia-induced disturbance of angiogenesis, and endothelial dysfunction play crucial role. Resveratrol (RES), silent information regulator 1 (SIRT1) agonist, can improve function has strong pro-angiogenic properties, thus become research focus for treatment diabetic ulcers; however, underlying mechanism by RES regulates these processes remains unclear. Therefore, present...
Studies regarding macroautophagic/autophagic regulation in endothelial cells (ECs) under diabetic conditions are very limited. Clinical evidence establishes an protective effect of metformin, but the underlying mechanisms remain unclear. We aimed to investigate whether metformin exerts its role against hyperglycemia-induced impairment through autophagy machinery. db/db mice were treated with intravitreal injections. Human umbilical vein (HUVECs) cultured either normal glucose (NG, 5.5 mM) or...
MiR-134 is a brain-enriched miRNA that plays an essential role in the development of embryonic stem cell-orientated differentiation to central nervous system by suppression Nanog and neural (including neurons, cylindraxile dendrites) has been shown be downregulated oligodendrogliomas (ODG) glioblastomas (GBM), suggesting its possible involvement brain tumor progression. In this study, we defined expression function miR-134, which found glioma samples glioblastoma cell line U87 SYBR green...
Abstract Kawasaki disease (KD) is an acute vasculitis of pediatric populations that may develop coronary artery aneurysms if untreated. It has been regarded as the principal cause acquired heart in children developed countries. Interleukin (IL)-37, one IL-1 family members, a natural suppressor inflammation caused by activation innate and adaptive immunity. However, detailed roles IL-37 KD are largely unclear. Sera from patients with displayed level was significantly decreased compared...
As the prevalence of systemic fungal infections caused by Candida albicans gradually increases, it is necessary to explore potential and effective antifungals. Carvacrol reported be lethally toxic C. albicans, involving several mechanisms. However, form specific mechanism cell death this compound has not been delineated. In study, we found that carvacrol could significantly decrease survival rates, consistent with previous researches. Further examination proved treatment membrane...
Insulin-like growth factor I receptor (IGF1R) is frequently upregulated in breast cancer. Due to its intrinsic tyrosine kinase activity, aberrant activation of the IGF1R signaling axis may enhance tumor cell proliferation and cancer stemness, causing relapse, metastasis resistance chemotherapy. We utilized a chromatin RNA situ reverse transcription (CRIST) approach characterize molecular factors that regulate network. identified lncRNA HULC (Highly Upregulated Liver Cancer) as key...
Vascular complications of diabetes are a serious challenge in clinical practice, and effective treatments an unmet need. Acidic fibroblast growth factor (aFGF) has potent anti-oxidative properties therefore become research focus for the treatment diabetic vascular complications. However, specific mechanisms by which aFGF regulates these processes remain unclear. The purpose this study was to investigate whether alleviates endothelial dysfunction suppressing mitochondrial oxidative stress. We...
Baicalin is the major component found in Scutellaria baicalensis root, a widely used herb traditional Chinese medicine, which exhibits strong anti-inflammatory, anti-viral and anti-tumor activities. The present work was devoted to elucidate molecular cellular mechanisms underlying protective effects of against diabetes-induced oxidative damage, inflammation endothelial dysfunction. Diabetic mice, induced by streptozotocin (STZ), were treated with intraperitoneal injections. Human umbilical...
Radiation is a therapeutic strategy for the treatment of cancer, and also used hepatocellular carcinoma. MicroRNAs (miRs) are endogenous, non‑coding single‑stranded RNA molecules, which regulate gene expression at post‑transcriptional level. In present study, roles miR‑34a‑mediated glycolysis in radiation sensitivity were investigated. By establishing radioresistant liver cancer cell line, study compared level miR‑34a from radiosensitive cells using reverse transcription‑quantitative...
FGF13 is an intracellular FGF factor. Its role in cardiomyopathies has been rarely investigated. We revealed that endogenous up-regulated cardiac hypertrophy accompanied by increased nuclear localization. The upregulation of plays a deteriorating both hypertrophic cardiomyocytes and mouse hearts. Mechanistically, directly interacts with p65 its localization sequence co-localizes the nucleus hypertrophy. deficiency inhibits NF-κB activation ISO-treated NRCMs TAC-surgery hearts, whereas...
The objective of this study is to identify the expression status and clinical implications lipase member H (LIPH) in breast cancer order develop strategies for management. LIPH was detected 346 specimens by immunohistochemistry. relationship between expression, clinico-pathological parameters, prognosis determined. higher than paracarcinoma tissues (P=0.01). In total, 64.74% (224/346) samples had high protein. related tumor size, histological grade, lymph node metastasis, distant metastasis...
Bovine viral diarrhea virus (BVDV) is the causative agent of bovine diarrhea-mucosal disease, which significantly affects production performance cattle, causing serious economic losses to cattle industries worldwide. Up now, some mechanisms involved in host-BVDV interaction are still not fully understood. The discovery long non-coding RNAs (lncRNAs) has provided a new perspective on gene regulation diverse biological contexts, particularly infection and host immune responses. However, little...
Natural killer (NK) cells perform immune surveillance functions in tumors. The antitumor effects of NK are closely related to tumor occurrence and development. However, the molecular factors that determine cell activity remain be characterized. In present study, we identified a novel long noncoding RNA (lncRNA), activity-associated lncRNA 1 (NCAL1), investigated its function cells. NCAL1 was primarily located nuclei, where it functioned by activating Gab2, scaffold protein with an essential...
Abstract Long noncoding RNA colon cancer‐associated transcript 2 (CCAT2) has been recently found to function as an oncogene in hepatocellular carcinoma (HCC). However, the mechanisms of CCAT2 HCC development remain be further explored. In present study, we that was abnormally upregulated cells and tissue specimens, exhibiting inverse correlation with microRNA (miR)‐145 expression. Mechanistic investigation showed selectively blocked miR‐145 processing, leading decreased mature presence. Both...
This work investigates the spherically symmetric thin-shell wormhole solutions in four-dimensional Einstein-Gauss-Bonnet theory and explores their stabilities under radial, linear perturbations. These are typically traversable characterized by a throat accordance with Israel's junction conditions. In asymptotically flat AdS spacetimes negative Gauss-Bonnet coupling constant, stable neutral wormholes encountered when magnitude of constant becomes significant. The throats such sustained...