A5102977141- Kawasaki Disease and Coronary Complications
- Coronary Artery Anomalies
- Cardiovascular Issues in Pregnancy
- Inflammasome and immune disorders
- Viral Infections and Immunology Research
- Neonatal Health and Biochemistry
- Metabolism and Genetic Disorders
- Mechanical Circulatory Support Devices
- Neonatal and Maternal Infections
- Neonatal Respiratory Health Research
- Circular RNAs in diseases
- interferon and immune responses
- Cardiac Structural Anomalies and Repair
- Congenital Heart Disease Studies
- Pregnancy and preeclampsia studies
- Hormonal Regulation and Hypertension
- Folate and B Vitamins Research
- Cardiac Arrhythmias and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Neonatal and fetal brain pathology
- Infant Nutrition and Health
- Cardiac pacing and defibrillation studies
- Sulfur Compounds in Biology
- Atrial Fibrillation Management and Outcomes
- Birth, Development, and Health
University of California, Berkeley
2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2009-2025
Wenzhou Medical University
2013-2025
Longgang Central Hospital
2008-2024
Shandong First Medical University
2023
Shandong Provincial Hospital
2023
Shandong University
2023
Abstract Kawasaki disease (KD) is the most common cause of pediatric cardiac in developed countries, and can lead to permanent coronary artery damage long term sequelae such as aneurysms. Given prevalence severity KD, further research warranted on its pathophysiology. It known that endothelial cell inflammation are two essential processes resulting dysfunction KD. However, detailed mechanisms largely unknown. In this study, we investigated role pyroptosis setting hypothesized may play a...
The outcome of preterm infants has been varied in different hospitals and regions developing countries. Regular clinical monitor are needed to know the effects health care. This study aimed describe survival morbidity rates extreme very 15 neonatal-intensive care China.Data were collected from January 1, 2013 December 31, 2014 for neonates with gestational age (GA) between 24 31 complete weeks born our collaborative group. primary outcomes major morbidities prior hospital discharge. Major...
Abstract Kawasaki disease (KD) is an acute vasculitis of pediatric populations that may develop coronary artery aneurysms if untreated. It has been regarded as the principal cause acquired heart in children developed countries. Interleukin (IL)-37, one IL-1 family members, a natural suppressor inflammation caused by activation innate and adaptive immunity. However, detailed roles IL-37 KD are largely unclear. Sera from patients with displayed level was significantly decreased compared...
The aim of this study was to investigate the characteristics Kawasaki disease (KD) in patients demonstrating pneumonia-like changes and pulmonary complications, as well subsequent impact on coronary artery lesions, by comparing them with those KD normal imaging. From January 1, 2013 October 2022, included paediatric diagnosed who were registered database at Yuying Children's Hospital affiliated Wenzhou Medical University. Patients divided into three distinct groups based presence severity...
Accurate prediction of intravenous immunoglobulin (IVIG) resistance is crucial for the effective treatment Kawasaki disease(KD). This study aimed to develop a predictive model IVIG in patients with disease and identify key predictors. The training set underwent cross-validation, models were constructed using six machine learning algorithms. Model performance was validated through test evaluation, two external validation sets evaluation. random forest algorithm demonstrated best overall among...
This study aims to investigate the pre- and postconditioning effects of lipoxin A 4 (LXA ) on myocardial damage caused by ischemia/reperfusion (I/R) injury. Seventy-two rats were divided into 6 groups: sham groups (C 1 C 2 ), I/R (I/R plus LXA preconditioning (LX LX ). The serum levels IL-1 β , IL-6, IL-8, IL-10, TNF- α cardiac troponin I (cTnI) measured. content activity Na + -K -ATPase as well superoxide dismutase (SOD), malondialdehyde (MDA) determined. Along with examination myocardium...
Increasing evidence indicates that microRNAs (miRNAs) play important roles in Kawasaki disease (KD). Our previous study demonstrated hsa-miR-27b-3p (miR-27b) was up-regulated KD serum. However, the specific role of miR-27b remains unclear. We aimed to investigate could be a biomarker and therapeutic target for treatment. As well, mechanism effecting endothelial cell functions studied.The expression Smad7 measured by qRT-PCR. Gain-of-function strategy used observe effect on human umbilical...
Objective: Kawasaki disease (KD) is a systemic vasculitis with serious complications, especially the development of coronary artery lesions (CALs). The aim this study was to identify risk for CALs IVIG treatment KD >10 days after illness onset in patients different status, and explore potential moderators association between delayed CALs.Methods: We performed retrospective review medical records patients. All were divided into two groups (conventional therapy group group, ≤10 vs days)....
Neonatal sepsis with meningoencephalitis is a common complication of sepsis, which leading cause neonatal death and neurological dysfunction. Early identification particularly important for reducing brain damage. We recruited 70 patients 42 were diagnosed as meningoencephalitis, collected cerebrospinal fluid (CSF) serum samples. The purpose this study was to find meningoencephalitis-related markers using unbiased metabolomics technology artificial intelligence analysis based on machine...
Objective . To investigate the association between aspartate aminotransferase (AST)/alanine (ALT) ratio (AST/ALT ratio, AAR) and intravenous immunoglobulin (IVIG) resistance, coronary artery lesions (CAL), aneurysms (CAA) in children with Kawasaki disease (KD). Design We retrospectively studied 2678 KD divided them into two groups: a low-AAR group high-AAR median AAR of 1.13 as cut-off point. The differences laboratory data, clinical manifestations, damage rates were compared groups. Results...
Early identification of neonatal jaundice (NJ) appears to be essential avoid bilirubin encephalopathy and neurological sequelae. The interaction between gut microbiota metabolites plays an important role in early life. It is unclear whether the composition can used as indicator NJ or aid clinical decision-making. This study involved a total 196 neonates conducted two rounds "discovery-validation" research on microbiome-metabolome. utilized methods machine learning, causal inference,...
Abstract Objective This study was performed to explore the clinical features of Kawasaki disease shock syndrome and analyse association between left ventricular ejection fraction syndrome. Methods We retrospectively reviewed medical records all consecutive inpatients with at Wenzhou Medical University Second Affiliated Hospital Yuying Children’s in Wenzhou, China from January 2009 December 2016. compared characteristics, laboratory data, patients without analysed effect on under different...
Neonatal hyperbilirubinemia, also known as neonatal jaundice, is a common and frequent clinical condition with complex etiology that can lead to brain damage in severe cases. Early recognition of hyperbilirubinemia timely intervention treatment help reduce the occurrence sequelae. This study was conducted identify whether gut microbiota composition distinguish neonates hyperbilirubinemia.Meconium samples were collected from 69 jaundice (NJ) age- sex-matched without clinically significant...
Autism spectrum disorder (ASD) affects more than 1% of children, and there is no viable pharmacotherapeutic agent to treat the core symptoms ASD. Studies have shown that children with ASD show changes in their levels immune response molecules. Our previous studies common folate receptor autoantibodies. We also found abnormal gut function, which was characterized by a significant increase content immunoglobulin A an gut-microbiota-associated epitope diversity. These suggest mechanism plays...
Albumin (ALB) level is closely associated with the occurrence of intravenous immunoglobulin (IVIG) resistance and coronary artery lesions (CALs) in Kawasaki disease (KD). The association between ALB CALs progression, critical to prognosis KD patients. But little known about it. This study aims investigate effect on progression patients.A total 3,479 patients from 1 January 2005 30 November 2020, Wenzhou, China were recruited. A 319 who had data, finish follow-up as requested enrolled this...
Abstract Background Kawasaki disease (KD) is the leading cause of acquired heart in children, and steadily increasing prevalence East Asia. KD often complicated by coronary artery damage, including dilatation and/or aneurysms. Aspirin used with intravenous immunoglobulin (IVIG) to prevent abnormalities KD. However, role optimal dose aspirin remain controversial. Identifying acute phase will facilitate development a more appropriate treatment strategy improving outcome Methods A total 2369...