A5100725465- Stress Responses and Cortisol
- Neonatal Respiratory Health Research
- Acute Ischemic Stroke Management
- Gastric Cancer Management and Outcomes
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Mental Health Research Topics
- Evolutionary Psychology and Human Behavior
- Dialysis and Renal Disease Management
- Neuroendocrine regulation and behavior
- Birth, Development, and Health
- Traumatic Brain Injury and Neurovascular Disturbances
- Pancreatic and Hepatic Oncology Research
- Gut microbiota and health
- Psychological Well-being and Life Satisfaction
- Intracerebral and Subarachnoid Hemorrhage Research
- Sleep and related disorders
- Death Anxiety and Social Exclusion
- Circadian rhythm and melatonin
- Muscle Physiology and Disorders
- COVID-19 and Mental Health
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Spondyloarthritis Studies and Treatments
- Heart Rate Variability and Autonomic Control
- Renal Transplantation Outcomes and Treatments
The University of Tokyo
2022-2025
Southern Medical University
2022-2025
Aviation General Hospital
2020-2025
Nanfang Hospital
2022-2025
Chinese People's Liberation Army
2023-2025
Southwest University
2018-2024
National Comprehensive Cancer Network
2024
China Pharmaceutical University
2023-2024
Army Medical University
2024
Southwest Hospital
2024
The outcome of preterm infants has been varied in different hospitals and regions developing countries. Regular clinical monitor are needed to know the effects health care. This study aimed describe survival morbidity rates extreme very 15 neonatal-intensive care China.Data were collected from January 1, 2013 December 31, 2014 for neonates with gestational age (GA) between 24 31 complete weeks born our collaborative group. primary outcomes major morbidities prior hospital discharge. Major...
Background This study aims to develop an oral microbiota-based model for gastric cancer (GC) risk stratification and prognosis prediction.
The major challenge for progressive multiple sclerosis therapy is the promotion of remyelination from inflammation-induced demyelination. A switch an M1- to M2-dominant polarization microglia critical in these repair processes. In this study, we identified homeobox gene msh-like homeobox-3 ( Msx3 ) as a new pivotal regulator microglial polarization. MSX3 was induced during M2 and repressed M1 cells. expression dynamically regulated experimental autoimmune encephalomyelitis (EAE), which...
Intracerebral hemorrhage (ICH) is the most lethal and devastating subtype of stroke. Basal ganglia thalamic are common types ICH, accounting for 50-70% all ICH cases, leading to disability death, it involves posterior limb internal capsule varying degrees. In this study, we investigated impact degrees involvement on prognosis patients with basal assessed whether improves predictive accuracy max-ICH score, an existing scale functional outcome. This a multicenter, retrospective, observational...
Chronic kidney disease (CKD) is an important affecting human health, especially in developing countries where CKD has high prevalence and mortality rates.[1] According to the latest epidemiological data, of among Chinese people 8.2%, which 1.8% are patients with stage 5 (known as end-stage renal [ESRD]).[2] Hemodialysis (HD) main treatment for ESRD patients. China National Renal Data System (CNRDS), number receiving HD 2022, was 844,000. Although dialysis can partially replace function...
Statins, HMG-CoA reductase inhibitors, have been widely prescribed to lower circulating low-density lipoprotein cholesterol levels and reduce the risk of cardiovascular disease. Although statins are well tolerated, statin-associated muscle symptoms (SAMS) major adverse effect cause statin intolerance. Therefore, understanding molecular mechanisms SAMS developing effective strategies for its prevention significant clinical importance; however, both remain unclear. Here we establish a model...
Studies in Western countries have repeatedly shown that women with a history of childhood sexual abuse (CSA) are at increased risk for developing major depression (MD). Would this relationship be found China?Three levels CSA (non-genital, genital, and intercourse) were assessed by self-report two groups Han Chinese women: 1970 clinically ascertained recurrent MD 2597 matched controls. Diagnostic other factor information was personal interview. Odds ratios (ORs) calculated logistic regression...
This study aims to explore the necessity and safety of digestive endoscopy during epidemic coronavirus disease 2019.A retrospective cohort method was used collect patients' data from center Civil Aviation General Hospital China February 1 May 31, 2020, as observation group. The endoscopic diagnosis treatment same period in 2019 were a control group, compare differences number detection rate gastrointestinal diseases two groups. At time, patients related staff followed up for situation new...
PARP7 plays a crucial role in cancer immunity. The inhibition of has shown potential boosting the immune response against cancer, making it an attractive target for immunotherapy. Herein, we employed rigid constraint strategy (reduction molecular flexibility) to design and synthesize series novel indazole-7-carboxamide derivatives based on structure RBN-2397. Among these derivatives, (S)-XY-05 was identified as most promising inhibitor (IC50: 4.5 nM). Additionally, showed enhanced...
In the previous 10 years, researchers have suggested a critical role for brain reward system in stress resilience. However, no study has provided an empirical link between activity mesostriatal regions during and recovery of cortisol response. Moreover, although sensitivity as trait been demonstrated to promote resilience, it remains unclear whether modulates resilience how this effect is achieved by inherent neuroendocrine system. To investigate these uncertainties, 70 young adults were...
Skeletal muscle mass is negatively regulated by several TGF-β superfamily members. Myostatin (MSTN) the most prominent negative regulator of mass. Recent studies show that in addition to MSTN, GDF11, which shares a high sequence identity with induces atrophy vitro and vivo at supraphysiological levels, whereas controversy regarding its roles exists. Furthermore, higher circulating GDF11 levels associate frailty humans. On other hand, little known about effect pathophysiological on atrophy....
The composition of the gut microbiota varies among end-stage renal disease (ESRD) patients on basis their mode replacement therapy (RRT), with notably more pronounced dysbiosis in those undergoing hemodialysis (HD). Interventions such as dialysis catheters, unstable hemodynamics, strict dietary restrictions, and pharmacotherapy significantly alter intestinal microenvironment, thus disrupting HD patients. may influence HD-related complications, including cardiovascular (CVD), infections,...
A blunted hypothalamic-pituitary-adrenal (HPA) axis response to acute stress is associated with psychiatric symptoms. Although the prefrontal cortex and limbic areas are important regulators of HPA axis, whether neural habituation these regions during signals both responses symptoms remains unclear. In this study, its associations cortisol response, resilience, depression were evaluated.Seventy-seven participants (17-22 years old, 37 women) recruited for a ScanSTRESS brain imaging activation...
Diabetic nephropathy (DN), as the one of most common complications diabetes, is generally diagnosed based on a longstanding duration, albuminuria, and decreased kidney function. Some patients with comorbidities diabetes other primary renal diseases have similar clinical features to DN, which defined non-diabetic disease (NDRD). It necessary distinguish between DN NDRD, considering they differ in their pathological characteristics, treatment regimes, prognosis. Renal biopsy provides gold...
Delicately phosphatized specimens of the eodiscoid Hupeidiscus orientalis were documented from lower Cambrian Shuijingtuo Formation through acetic acid maceration limestone samples.The material enables us to better understand meraspid holaspid ontogenetic development H. orientalis, and evaluate its relations with other taxa occurring in South China.The pygidium thoracic segments is very similar that "Shizhudiscus" longquanensis, suggesting Shizhudiscus a junior synonym Hupeidiscus.However,...
Abstract The role of pathological response in long-term outcome is still unclear cervical cancer patients treated with neoadjuvant chemotherapy (NACT) China. This study aimed to investigate the effect optimal pathologic (OPR) on survival NACT and radical hysterectomy. First, 853 stage IB2-IIB were included a retrospective analysis; Cox proportional hazards model was used relationship between disease-free (DFS). In database, 64 (7.5%) found have achieved an OPR (residual disease <3 mm...
We previously found that neurocritically ill patients are prone to refeeding syndrome (RFS), a potentially life-threatening complication. However, there is no unified or validated consensus on the screening tool for RFS so far. aimed validate and compare performance of four tools in patients. conducted single-center, observational, retrospective cohort study among adult who were admitted neurocritical care unit (NCU), received enteral nutrition 72 h longer. They scored Short Nutritional...
Daily life stressors include everyday irritants, hassles, and inconveniences, such as problems in traffic unexpected work deadlines. A growing body of research has suggested higher daily stress is associated with blunted cortisol response to acute psychosocial stressors. However, so far, the neural mechanism underlying this association not been elucidated. The current study aimed examine role neurocircuitry between hippocampus ventral medial prefrontal cortex relationship.To end, an index 44...
Chinese yam (Dioscorea polystachya Turczaninow cv. Tiegun), which belongs to the family Dioscoreaceae, is widely cultivated throughout China due its high economic and medicinal value. In June 2023, black leaf spots on (cv. Purple 1) were observed in Nanchang city (28.45° N, 115.49° E) of Jiangxi province, southeastern China. The incidence disease ranged between 70 85% plants, up 30% leaves per plant affected field over a 2-week period study. Infected foliage displayed brown necrotic lesions,...