A5100667447- Reproductive Biology and Fertility
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Nanoplatforms for cancer theranostics
- Cervical Cancer and HPV Research
- Ovarian function and disorders
- Genetics, Aging, and Longevity in Model Organisms
- Endometriosis Research and Treatment
- RNA Interference and Gene Delivery
- Gynecological conditions and treatments
- Birth, Development, and Health
- Reproductive System and Pregnancy
- Renal and related cancers
- Luminescence and Fluorescent Materials
- Uterine Myomas and Treatments
- Advanced Combustion Engine Technologies
- COVID-19 Impact on Reproduction
- Combustion and flame dynamics
- Telomeres, Telomerase, and Senescence
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Advanced Photocatalysis Techniques
- COVID-19 and healthcare impacts
- Cancer Risks and Factors
Tongji Hospital
2016-2025
Huazhong University of Science and Technology
2016-2025
National Clinical Research Center for Digestive Diseases
2020-2025
Ministry of Education of the People's Republic of China
2021-2025
Guangdong Medical College
2024-2025
Guilin University of Technology
2025
Anhui University of Science and Technology
2024
Tianjin University
2018-2024
Nanchang University
2021-2024
First Affiliated Hospital of Nanchang University
2021-2024
Multimodal therapy is attracting increasing attention to improve tumor treatment efficacy, but generally requires various complicated ingredients combined within one theranostic system achieve multiple functions. Herein, a multifunctional nanoplatform based on single aggregation-induced-emission luminogen (AIEgen), DDTB, designed integrate near-infrared (NIR) fluorescence, photothermal, photodynamic, and immunological effects. Intravenously injected AIEgen-based nanoparticles can efficiently...
Objective: This study was intended to investigate the relationship between COVID-19 disease and ovarian function in reproductive-aged women. Methods: Female patients of reproductive age were recruited January 28 March 8, 2020 from Tongji Hospital Wuhan. Their baseline clinical characteristics, as well menstrual conditions, recorded. Differentials reserve markers sex hormones (including anti-Müllerian hormone [AMH], follicle-stimulating [FSH], ratio FSH luteinizing [LH], estradiol [E2],...
The ability to track the levels of specific molecules, such as drugs, metabolites, and biomarkers, in living body, real time for long durations, would improve our understanding health diagnose, treat, monitor disease. To this end, we are developing electrochemical aptamer-based (EAB) biosensors, a general platform supporting high-frequency, real-time molecular measurements body. Here report that use an agarose hydrogel protective layer EAB sensors significantly improves their signaling...
Abstract Limited understanding exists regarding how aging impacts the cellular and molecular aspects of human ovary. This study combines single-cell RNA sequencing spatial transcriptomics to systematically characterize ovarian aging. Spatiotemporal signatures eight types cells during are observed. An analysis age-associated changes in gene expression reveals that DNA damage response may be a key biological pathway oocyte Three granulosa subtypes five theca stromal subtypes, as well their...
Recent studies have indicated that females with coronavirus disease 2019 (COVID-19) a lower morbidity, severe case rate, and mortality better outcome than those of male individuals. However, the reasons remained to be addressed.
Persistent HPV infection is recognized as the main etiologic factor for cervical cancer. expresses oncoproteins E6 and E7, both of which play key roles in maintaining viral promoting carcinogenesis. While siRNA-mediated targeting E7 transcripts temporarily induces apoptosis HPV-positive cells, it does not eliminate DNA within host genome, can harbor escape mutants. Here, we demonstrated that specifically with transcription activator-like effector nucleases (TALENs) apoptosis, inhibits...
Synergistic phototherapy provides a promising strategy to conquer the hypoxia and heterogeneity of tumors realize better therapeutic effect than monomodal photodynamic therapy (PDT) or photothermal (PTT). The development efficient multifunctional organic phototheranostic systems still remains challenging task. Herein, 9,10-phenanthrenequinone (PQ) with strong electron-withdrawing ability is conjugated rotor-type electron-donating triphenylamine derivatives create series tailor-made...
Red blood cell (RBC)-mimicking nanoparticles (NPs) offer a promising platform for drug delivery because of their prolonged circulation time, reduced immunogenicity and specific targeting ability. Herein, we report the design preparation RBC membrane-bound NPs (M@AP), tumoral photodynamic-immunotherapy. The M@AP is formed by self-assembly positively charged aggregation-induced emission luminogen (AIEgen) (named P2-PPh3) negatively polyinosinic : polycytidylic acid (Poly(I C)), followed...
Fine particulate matter (PM2.5) pollution arouses public health concerns over the world. Increasing epidemiologic evidence suggests that exposure to ambient airborne PM2.5 increases risk of female infertility. However, relatively few studies have systematically explored harmful effect chronic on ovarian function and underlying mechanisms. In this study, C57BL/6J mice are exposed filtered air or urban for 4 months through a whole-body system. It is found significantly caused alteration estrus...
Abstract Ovarian injury caused by chemotherapy can lead to early menopause, infertility, and even premature senility in female cancer patients, impairing the quality of life overall health survivors seriously. However, there is still a lack effective protection strategies against such injury. Cellular senescence be induced chemotherapeutic agents multiple organs may corrode structure function normal tissues. We hypothesized that widely used first-line drug, doxorubicin, could increase...
Abstract STUDY QUESTION What is the current burden of infertility attributable to PCOS at global, regional, and national levels by age socio-demographic index (SDI) across 21 regions 204 countries territories? SUMMARY ANSWER The increased from 6.00 million prevalent cases in 1990 12.13 2019 globally sharply most nations. WHAT IS KNOWN ALREADY common cause anovulatory infertility, affecting up 80% women with anovulation. No comprehensive detailed epidemiological estimates reproductive aged...
With increasing proportion of the elderly in population, age-related diseases (ARD) lead to a considerable healthcare burden society. Prevention and treatment ARD can decrease negative impact aging disease. The rate is closely associated with production high levels reactive oxygen species (ROS). ROS-mediated oxidative stress triggers aging-related changes through lipid peroxidation, protein oxidation, DNA oxidation. Antioxidants control autoxidation by scavenging free radicals or inhibiting...
The human female reproductive lifespan significantly diminishes with age, leading to decreased fertility, reduced fertility quality and endocrine function disorders. While many aspects of aging in general have been extensively documented, the precise mechanisms governing programmed system remain elusive. Recent advancements omics technologies computational capabilities facilitated emergence multiomics deep phenotyping. Through application refinement various high-throughput methods, a...