A5101675772- Air Quality and Health Impacts
- RNA modifications and cancer
- Extracellular vesicles in disease
- Phagocytosis and Immune Regulation
- Immune Cell Function and Interaction
- Energy and Environment Impacts
- Climate Change and Health Impacts
- Lung Cancer Treatments and Mutations
- Inflammation biomarkers and pathways
- Nosocomial Infections in ICU
- Lung Cancer Research Studies
- Agriculture Sustainability and Environmental Impact
- Inflammasome and immune disorders
- Autophagy in Disease and Therapy
- Phytochemical and Pharmacological Studies
- Medicinal plant effects and applications
- Oral Health Pathology and Treatment
- MicroRNA in disease regulation
- Plant Reproductive Biology
- Cancer-related molecular mechanisms research
- Protein Degradation and Inhibitors
- Iron Metabolism and Disorders
- Cynara cardunculus studies
- Employment and Welfare Studies
- Polysaccharides and Plant Cell Walls
Tongji University
2022-2025
Shanghai Pulmonary Hospital
2022-2025
Nanjing Maternity and Child Health Care Hospital
2025
Nanjing Medical University
2025
Shanxi Medical University
2024
Qingdao University
2024
University of Chinese Academy of Sciences
2018-2023
Shaoxing People's Hospital
2020
Fujian Agriculture and Forestry University
2019
Henan Provincial People's Hospital
2018
Fine particulate matter (PM2.5) pollution arouses public health concerns over the world. Increasing epidemiologic evidence suggests that exposure to ambient airborne PM2.5 increases risk of female infertility. However, relatively few studies have systematically explored harmful effect chronic on ovarian function and underlying mechanisms. In this study, C57BL/6J mice are exposed filtered air or urban for 4 months through a whole-body system. It is found significantly caused alteration estrus...
Lung adenocarcinoma (LUAD) radiologically displayed as subsolid nodules (SSNs) is prevalent. Nevertheless, the precise clinical management of SSNs necessitates a profound understanding their tumorigenesis and progression. Here, we analyze 66 LUAD covering 3 histological stages including in situ (AIS), minimally invasive (MIA) (IAC) by incorporating genomics, proteomics, phosphoproteomics glycoproteomics. Intriguingly, cholesterol metabolism aberrantly regulated preneoplastic AIS stage....
The association between airborne fine particulate matter (PM
Enhancing chemosensitivity is one of the largest unmet medical needs in cancer therapy. Cyclic GMP-AMP synthase (cGAS) connects genome instability caused by platinum-based chemotherapeutics to type I interferon (IFN) response. Here, using a high-throughput small-molecule microarray-based screening cGAS interacting compounds, we identify brivanib, known as dual inhibitor vascular endothelial growth factor receptor and fibroblast receptor, modulator. Brivanib markedly enhances cGAS-mediated...
Highlights•The amount of dopamine is positively correlated with circulating B cell numbers in humans•Dopamine activates antitumor responses via DRD5•Dopamine enhances through JAK1-STAT1 signaling•Combining the DRD5 agonist PD-1 antibody therapy elicited robust effectsSummaryNeuronal signals have emerged as pivotal regulators cells that regulate immunity and tumor progression. However, functional relevance mechanistic basis effects neurotransmitter (DA) on remain elusive. Here, we discovered...
Abstract Exposure of airborne particulate matter (PM) with an aerodynamic diameter less than 2.5 μm (PM2.5) is epidemiologically associated lung dysfunction and respiratory symptoms, including pulmonary fibrosis. However, whether epigenetic mechanisms are involved in PM2.5-induced fibrosis currently poorly understood. Herein, using a mouse model, we found that PM2.5 exposure leads to aberrant mRNA 5-methylcytosine (m5C) gain loss fibrotic tissues. Moreover, showed the m5C-mediated regulatory...
Abstract Pectin synthesis and modification are vital for plant development, although the underlying mechanisms still not well understood. Here, we report functional characterization of OsTSD2 gene, which encodes a putative methyltransferase in rice. All three independent T-DNA insertion lines displayed dwarf phenotypes serial alterations different zones root. These included abnormal cellular adhesion schizogenous aerenchyma formation meristematic zone, inhibited root elongation higher...
OsMADS16, a class B floral organ identity gene, plays pivotal role in stamen formation rice. To date, little is known about the interacting partners of OsMADS16 except for several MADS-box proteins. In this study, we constructed high-quality cDNA library young panicles (< 5 cm length) and performed yeast two-hybrid (Y2H) screening using as bait. Eleven candidate proteins with were identified by Y2H validated BiFC Co-IP assays. Subcellular localization results further confirmed possibility...
Background To date, more than 770 million individuals have become coronavirus disease 2019 (COVID-19) convalescents worldwide. Emerging evidence highlights the influence of COVID-19 on oral microbiome during both acute and convalescent phases. Front-line healthcare workers are at an elevated risk exposure to viral infections, effects their remain relatively unexplored. Methods Oropharyngeal swab specimens, collected one month after a negative test from cohort comprising 55 workers, underwent...
During development in the thymus, each T lymphocyte is equipped with one, essentially unique, cell receptor (TCR)-specificity. Due to its random nature, this process inevitably also leads emergence of potentially dangerous lymphocytes that may recognize 'self.' Nevertheless, autoimmune tissue destruction, cause diseases such as multiple sclerosis and diabetes, exception rather than rule. This state immunological self-tolerance a large degree based upon called 'negative selection': prior...
Macroautophagy serves cellular housekeeping and metabolic functions through delivery of cytoplasmic constituents for lysosomal degradation.In addition, it may mediate the unconventional presentation intracellular antigens to CD4 + T cells; however, physiological relevance this endogenous MHC class II loading pathway remains poorly defined.Here, we characterize role macroautophagy in thymic epithelial cells (TECs) negative selection.Direct clonal deletion II-restricted thymocytes required a...
We report a novel β-globin gene promoter mutation in Chinese family identified using fluorescence resolution melting curve analysis and sequencing. The proband, who showed the phenotype of β-thalassemia intermedia (β-TI), was found to be compound heterozygote for −25 (G>T) (HBB: c.-75G>T) codon 17 c.52A>T) mutation. Moreover, conservation phyloP phastCons indicated that mutated base proband conserved. This point on is close proximity conserved ATAA sequence located at position relative mRNA...
Lung adenocarcinoma (LUAD) is one of the most prevalent forms lung cancer. Competitive endogenous RNA (ceRNA) plays an important role in pathogenesis Phosphatase and tensin homolog (PTEN) frequently deleted tumour suppressor genes LUAD. The present study aimed to identify a novel PTEN-associated-ceRNA regulatory network potential prognostic markers associated with Transcriptome sequencing profiles 533 patients LUAD were obtained from TCGA database, differentially expressed (DEGs) screened...
<title>Abstract</title> <bold>Background</bold> China is experiencing an aging population, resulting in a huge demand for "Internet plus + nursing services", new service model. However, there are many risk problems the process of shared nurse service. In order to improve willingness nurses continue participate, work family support scale used assess face service". <bold>Aims</bold> To level work-family among and analyze current situation factors that influence it. <bold>Methods</bold> A...
Objective To evaluate the effect of dexmedetomidine on high-mobility group box 1 protein (HMGB1)/Toll-like receptors (TLRs) signaling pathway during lung injury in septic rats. Methods Twenty-four SPF healthy adult male Wistar rats, aged 15-18 weeks, weighing 200-250 g, were divided into 3 groups (n=8 each) using a random number table: sham operation (group S), sepsis Sep) and D). Dexmedetomidine 25 μg/kg was intraperitoneally injected D group, while equal volume normal saline given...