A5101635646- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Neuroinflammation and Neurodegeneration Mechanisms
- Helicobacter pylori-related gastroenterology studies
- High Altitude and Hypoxia
- Advanced Computational Techniques and Applications
- Antibiotic Resistance in Bacteria
- Gastroesophageal reflux and treatments
- Immune cells in cancer
- Protein Tyrosine Phosphatases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Computational Drug Discovery Methods
- Neuroscience of respiration and sleep
- Bacterial Genetics and Biotechnology
- Optimization and Search Problems
- Robotics and Sensor-Based Localization
- Cancer Genomics and Diagnostics
- Robotic Path Planning Algorithms
- Diffusion and Search Dynamics
- Sulfur Compounds in Biology
- Guidance and Control Systems
- Lipid Membrane Structure and Behavior
- Security in Wireless Sensor Networks
- Advanced Authentication Protocols Security
- Facility Location and Emergency Management
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Peking Union Medical College Hospital
2020-2024
Chinese Institute for Brain Research
2024
Shanghai University
2024
University of Chinese Academy of Sciences
2016-2022
Weatherford College
2022
Shijiazhuang University
2017-2021
PLA Army Engineering University
2017-2021
Inner Mongolia Maternal and Child Health
2021
Yunnan University
2021
Protein tyrosine phosphatase SHP2 is an oncoprotein associated with cancer as well a potential immune modulator because of its role in the programmed cell death PD-L1/PD-1 pathway. In preceding manuscript, we described optimization fused, bicyclic screening hit for potency, selectivity, and physicochemical properties order to further expand chemical diversity allosteric inhibitors. this describe expansion our approach, morphing system into novel monocyclic pyrimidinone scaffold through...
Ischemic stroke is characterized by the presence of reactive microglia. However, its precise involvement in etiology still unknown. We used metabolic profiling and showed that chemokine like factor 1 (CKLF1) causes acute microglial inflammation reprogramming from oxidative phosphorylation to glycolysis, which was reliant on AMP-activated protein kinase (AMPK)-mammalian target rapamycin (mTOR)-hypoxia inducible 1α (HIF-1α) signaling pathway. Once activated, microglia enter a chronic tolerant...
The association between airborne fine particulate matter (PM
The outbreak of COVID-19 is a public health crisis that has had profound impact on society. Stigma common phenomenon in the prevalence and spread infectious diseases. In caused by pandemic, widespread stigma influenced social groups. This study explores negative emotions arousal effect from online stigmatization during pandemic cooperation. We constructed model based literature tested it sample 313 participants group being stigmatized. results demonstrate: (1) relevance perception promote...
Abstract Background Airborne fine particulate matter with aerodynamic diameter ≤ 2.5 μm (PM ) pollution is associated the prevalence of respiratory diseases, including asthma, bronchitis and chronic obstructive pulmonary disease. In patients those circulating asymmetric dimethylarginine (ADMA) levels are increased, which contributes to airway nitric oxide deficiency, oxidative stress inflammation. Overexpression dimethylaminohydrolase 1 (DDAH1), an enzyme degrading ADMA, exerts protective...
Abstract SecA is a central component of the general secretion system that essential for bacterial growth and thus an ideal target antimicrobial agents. A series fluorescein analogues were first screened against ATPase activity using truncated unregulated catalytic domain. Rose bengal (RB) erythrosin B (EB) found to be potent inhibitors with IC 50 values 0.5 μ M 2 , respectively. RB EB inhibit more effectively than F 1 0 ‐proton ATPase. We used three assays test effect these compounds on...
Abstract Anti-oxidant stress is a potential strategy for the treatment of ischemic stroke. Here, we found novel free radical scavenger termed as CZK, which derived from alkaloids contained in Clausena lansium . In this study, first compared cytotoxicity and biological activity between CZK its parent’s compound Claulansine F. It was that had lower improved anti-oxygen–glucose deprivation/reoxygenation (OGD/R) injury than compound. Free scavenging test showed strong inhibitory effect on...
Objectives: Aficamten is a selective, small-molecule allosteric inhibitor of cardiac sarcomere being developed as chronic oral treatment for patients with symptomatic obstructive hypertrophic cardiomyopathy. This was the first-in-Chinese study aiming to investigate safety, tolerability, pharmacokinetics, and pharmacodynamics aficamten in healthy adults. Methods: double-blind, randomized, placebo-controlled, phase 1 conducted 28 male female Chinese participants after single ascending dose...
Abstract Background: Delivery room resuscitation assists preterm infants, especially extremely infants (EPI) and low birth weight (ELBWI), in breathing support, while it potentially exerts a negative impact on the lungs outcomes of infants. This study aimed to assess delivery discharge EPI ELBWI China. Methods: The clinical data (gestational age [GA] <28 weeks) (birth [BW] <1000 g), admitted within 72 h 33 neonatal intensive care units from five provinces cities North China between...
The incidence and mortality rates of cancer have been increasing in developing countries, particularly Asia. Therefore to provide optimal comprehensive care the patients, plan must focus on needs patients. purpose this study was investigate explore associated factors. In a cross-sectional questionnaire study, total 200 patient-caregiver dyads were selected interviewed Mainland China by convenient sampling method. Patients' assessed with Comprehensive Needs Assessment Tool for Patients...
This study aimed to build a nasal semi-physiologically based pharmacokinetic (PBPK) model predict the intranasal (PK) of OC-01(varenicline) spray and accelerate development this drug. Based on physiology human upper respiratory system, semi-PBPK was established validated using systemic plasma PK data varenicline previously observed in Americans Chinese. Drug concentrations, both tissue circulation were well simulated, it indicated that local concentration at target site (nasal cavity)...
In this paper, we propose an effective algorithm for facial expression recognition (FER), which is based on completed local binary pattern (CLBP) and sparse representation. The new method solves representations both gray images of these images. Afterwards, obtain the results features by representation classification (SRC) method. Finally, final obtained fusion via comparing residue ratios representations. proposed experimented Japanese Female Facial Expression (JAFFE) database. experiment...