A5014828679- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
- Extracellular vesicles in disease
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Immune cells in cancer
- Cancer-related Molecular Pathways
- Liver Disease Diagnosis and Treatment
- Cancer Research and Treatments
- Epigenetics and DNA Methylation
- Thyroid Cancer Diagnosis and Treatment
- CAR-T cell therapy research
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Sarcoma Diagnosis and Treatment
- Bone Metabolism and Diseases
Shanghai University of Traditional Chinese Medicine
2022-2025
Nantong University
2021-2024
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2022-2024
Taizhou People's Hospital
2024
Nanjing Medical University
2024
Vrije Universiteit Amsterdam
2023
Shanghai Tenth People's Hospital
2013-2022
Tongji University
2013-2022
Nantong Tumor Hospital
2019-2022
Qinghai University
2022
The senescence-associated secretory phenotype (SASP) can be provoked by side effects of therapeutic agents, fueling advanced complications including cancer resistance. However, the intracellular signal network supporting initiation and development SASP driven treatment-induced damage remains unclear. Here we report that transcription factor Zscan4 is elevated for expression an ATM-TRAF6-TAK1 axis during acute DNA response enables a long term in human stromal cells. Further, TAK1 activates...
Significance TNFα is the key cytokine implicated in inflammatory bowel disease. However, not always proinflammatory, because TNFα-activated NF-κB induces prosurvival proteins, including c-FLIP, to constrain caspase 8 activation. Here we report that epithelial EZH2 integrates multifaceted effects of signaling promote inflammation and apoptosis colitis. reduction directly stimulates TRAF2/5 expression enhance TNFα-induced signaling. More importantly, deficiency up-regulates E3 ligase ITCH...
Previous evidence has highlighted M2 macrophage regulation of cancer cells via exosome shuttling microRNAs (miRNAs or miRs). The current study set out to explore the possible role macrophage-derived exosomal miR-155-5p in regard immune escape colon cells. Experimental data from quantitative reverse-transcriptase PCR (qRT-PCR) and western blot analysis revealed highly expressed interleukin (IL)-6 poorly ZC3H12B exosomes. Additionally, could be transferred by macrophage-isolated exosomes...
Cancer cachexia is a kind of whole-body metabolic disorder syndrome accompanied by severe wasting muscle tissue in which cancer exosomes may be involved. Analysis clinical samples showed that the serum exosome concentrations were correlated with development cachexia. Exosomes secreted C26 cells could decrease diameter C2C12 myotubes vitro and mouse strength tibialis anterior (TA) weight vivo. GW4869, an inhibitor excretion, ameliorated tumor-bearing mice. MicroRNA (miRNA) sequencing...
Abstract MicroRNA‐24‐3p (miR‐24‐3p) has been implicated as a key promoter of chemotherapy resistance in numerous cancers. Meanwhile, cancer‐associated fibroblasts (CAFs) can secret exosomes to transfer miRNAs, which mediate tumour development. However, little is known regarding the molecular mechanism CAF‐derived exosomal miR‐24‐3p colon cancer (CC). Hence, this study intended characterize functional relevance CC cell methotrexate (MTX). We identified differentially expressed HEPH, CDX2 and...
Abstract Background Cancer cachexia is a multifactorial metabolic syndrome in which bile acid (BA) metabolism might be involved. The aim of the present study was to clarify contribution liver and gut microbiota BA disturbance cancer check possibility targeting using agents such as tauroursodeoxycholic (TUDCA) for therapy. Methods profiles liver, intestine, serum mice with induced by inoculation colon C26 tumour cells were analysed metabolomics methods compared that control mice. Proteomic...
Bone is a common site of metastasis in lung cancer, but the regulatory mechanism remains incompletely understood. Osteoclasts are known to play crucial roles osteolytic bone by digesting matrix and indirectly enhancing tumor colonization. In this study, we found that IL receptor 20 subunit β (IL-20RB) mediated direct tumoral response osteoclasts. Tumoral expression IL-20RB was associated with functionally, promoted metastatic growth cancer cells bone. Mechanistically, induced osteoclasts...
Recent studies have implied that miRNAs may play a crucial role in tumor progression and be involved the modulation of some drug resistance cancer cells. Earlier demonstrated miR-194 was metastasis non-small cell lung (NSCLC), whereas their expression roles on NSCLC still need further elucidation. In current study, we found is decreased samples compared with adjacent non-cancerous samples, low predicts poor patient survival. Both vitro vivo experiments showed ectopic stable suppressed...
Proteogenomic characterization and integrative comparative genomic analysis provide a functional context to annotate abnormalities with prognostic value.Here, we analyzed the proteomes performed whole exome transcriptome sequencing single nucleotide polymorphism array profiling for 2 sets of triplet samples comprised normal colorectal tissue, primary CRC synchronous matched liver metastatic tissue.We identified 112 CNV-mRNA-protein correlated molecules, including up-regulated COL1A2 BGN...
There is increasing evidence that liver cancer stem cells (LCSCs) contribute to hepatocellular carcinoma (HCC) initiation and progression. MicroRNA (miRNA) plays a significant functional role by directly regulating respective targets in LCSCs-triggered HCC, however, little known about the function of miRNA-302 family LCSCs.MiRNAs microarray was used detect miRNAs involved LCSCs maintenance differentiation. Biological roles molecular mechanism miRNA-302a/d its target gene E2F7 were detected...
We examined the effect of microRNA-320b (miR-320b) on tumor growth and angiogenesis in lung cancer also determined its downstream molecular mechanisms. Lung tissues adjacent non-cancerous were collected from 66 patients with cancer. miR-320b expression was experimentally to be expressed at low level tissues. The results gain-of-function experiments suggested that overexpression suppressed cell invasion, tube formation, volume xenografted nude mice. Hepatocyte nuclear factor 4 gamma (HNF4G)...
Anaplastic thyroid cancer (ATC) is associated with poor prognosis and often untreatable. MicroRNA 483-3p (miR-483) partitioning-defective 3 (Pard3), a member of the Pard family, have functions regulatory mechanisms in ATC. The abnormal regulation miR-483 may play an important role tumorigenesis, Par3 known to regulate cell polarity, migration, division. Tumor proliferation promoted by miRNA expression can be regulated upregulating transforming growth factor-β1 (TGF-β1), which thought...
As one of the common cancers that threaten human life, recurrence and metastasis colorectal cancer seriously affect prognosis patients. Although new drugs comprehensive treatments have been adopted, current treatment effect on this tumor, especially in advanced cancer, is still not satisfactory. More more evidence shows tumors are likely to be a stem cell disease. In recent years, rise theory has provided way for treatment. Studies found small number special cells tissues induce...