A5072024057- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Ultrasound Imaging and Elastography
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- MRI in cancer diagnosis
- MicroRNA in disease regulation
- RNA modifications and cancer
- Liver Disease and Transplantation
- Circular RNAs in diseases
- Pediatric Urology and Nephrology Studies
- Hepatitis B Virus Studies
- Esophageal Cancer Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Urological Disorders and Treatments
- Renal cell carcinoma treatment
- Breast Lesions and Carcinomas
- Gastroesophageal reflux and treatments
- Ultrasound in Clinical Applications
- Hemodynamic Monitoring and Therapy
- Angiogenesis and VEGF in Cancer
- Advanced MRI Techniques and Applications
- Breast Cancer Treatment Studies
- Thyroid Cancer Diagnosis and Treatment
Thomas Jefferson University
2016-2025
Shandong Academy of Sciences
2023-2025
Qilu University of Technology
2023-2025
Nantong Tumor Hospital
2014-2024
Nantong University
2020-2024
Chengdu University of Traditional Chinese Medicine
2022-2024
Tianjin University
2012-2024
Affiliated Zhongshan Hospital of Dalian University
2010-2024
Chengdu University
2022
Thomas Jefferson University Hospital
2008-2021
Graphical Abstract A valuable shell: The combination of electrostatic deposition gold nanoparticles onto microcapsules and a surface seeding method results in the formation nanoshells (see picture). This nano/microcomposite is able to operate as theranostic agent for both contrast-enhanced ultrasonic imaging (diagnostic) photohyperthermia (therapeutic), thus holds great potential photothermal therapy cancer treatment.
The early detection of hepatocellular carcinoma (HCC) presents a challenge because the lack specific biomarkers. Serum/plasma microRNAs (miRNAs) can discriminate HCC patients from controls. We aimed to identify and evaluate HCC‐associated plasma miRNAs originating liver as biomarkers for detecting HCC. In this multicenter three‐phase study, we first performed screening using both (HCC before after transplantation or hepatectomy) tissue samples (HCC, para‐carcinoma cirrhotic tissues). Then,...
<h3>Importance</h3> Hepatitis B virus (HBV) has been identified as a major risk factor for hepatocellular carcinoma. However, the associations between HBV infection and other cancer types are not well understood. <h3>Objective</h3> To assess chronic of all types. <h3>Design, Setting, Participants</h3> This population-based study involved 3 cohorts in China. The China Kadoorie Biobank (CKB) prospective cohort study, conducted June 2004 July 2008, used dipstick assay detection serum hepatitis...
To establish a preoperative protocol for ultrasonographically guided percutaneous radiofrequency (RF) ablation of large liver tumors that is based on mathematic models and clinical experience to evaluate the role this in RF ablation.A regular prism polyhedron model were used develop tumor ablation. This enabled authors minimize number spheres, optimize overlapping mode, determine electrode placement process. One hundred ten patients with 121 treated by using protocol. Sixty-nine had 74...
Intravenously injected ultrasonic contrast agents making use of encapsulated gas microbubbles have excellent clinical potential for both color and spectral Doppler studies. However, a number artifacts are associated with sonographic agent measurements. Three were identified: (1) "blooming," (2) increased maximum shift, (3) "bubble noise." Experiments been conducted Albunex Levovist. These into rabbits humans to allow the cause be established. Color blooming occurs soon after bolus injection...
It has been demonstrated that there are abundant stable microRNAs (miRNAs) in plasma/serum, which can be detected and potentially disease specific. However, the lack of suitable endogenous controls for serum miRNA detection is restriction widely usage this kind biomarkers between-laboratory comparison findings. We first systematically screened control miRNAs (ECMs) by testing 10 pooling samples (using both Solexa sequencing TaqMan low density array) 50 individual quantitative reverse...
Genome-wide association studies (GWAS) have recently identified KIF1B as susceptibility locus for hepatitis B virus (HBV)–related hepatocellular carcinoma (HCC). To further identify novel loci associated with HBV–related HCC and replicate the previously reported association, we performed a large three-stage GWAS in Han Chinese population. 523,663 autosomal SNPs 1,538 HBV–positive patients 1,465 chronic HBV carriers were genotyped discovery stage. Top candidate initial validation samples of...
The miR-34 family members are direct transcriptional targets of tumor suppressor p53, and loss function can impair p53-mediated cell cycle arrest apoptosis. A potentially functional SNP rs4938723 (T > C) was found in the promoter region pri-miR-34b/c (423 bp from transcription start site), located CpG island might affect factor GATA binding therefore expression. In our study, we hypothesized that SNPs miR-34b/c TP53 Arg72Pro may independently or jointly contribute to primary hepatocellular...
Recent genome-wide association studies showed that four single-nucleotide polymorphisms (SNPs) in human leukocyte antigen (HLA)-DP (rs3077 and rs9277535) HLA-DQ (rs2856718 rs7453920) were associated with chronic hepatitis B virus (HBV) infection Japanese populations. More than 75% of hepatocellular carcinoma (HCC) patients are attributable to persistent (HBV), especially China. We genotyped these SNPs 1,300 HBV-positive HCC patients, 1,344 HBV carriers, persons natural clearance from...
Background Recently, several studies have demonstrated that two long non-coding RNAs (lncRNAs), HULC and MALAT1, may participate in hepatocellular carcinoma (HCC) development progression. However, genetic variations the lncRNAs their associations with HCC susceptibility not been reported. In this study, we hypothesized single nucleotide polymorphisms (SNPs) MALAT1 contribute to risk. Methods We conducted a case-control study genotyped SNPs, rs7763881 rs619586 1300 HBV positive patients, 1344...
Background: No conventional imaging method reliably distinguishes between benign and malignant thyroid nodules. Our objectives were to characterize the enhancement patterns of nodules on gray-scale contrast-enhanced ultrasound (US) evaluate whether these useful in differential diagnosis Methods: Ninety-five patients, scheduled for surgery detected by sonography, enrolled this prospective study. In all, there 104 (47 papillary carcinomas, 3 medullary 1 metastatic carcinoma, 44 hyperplasia...
Novel biocompatible nanobubbles were fabricated by ultrasonication of a mixture Span 60 and polyoxyethylene 40 stearate (PEG40S) followed differential centrifugation to isolate the relevant subpopulation from parent suspensions. Particle sizing analysis optical microscopy inspection indicated that freshly generated micro/nanobubble suspension was polydisperse size distribution bimodal with large amounts nanobubbles. To develop nano-sized contrast agent is small enough leak through tumor...
Background American College of Radiology contrast agent–enhanced US Liver Imaging Reporting and Data System (CEUS LI-RADS) was developed to improve the accuracy hepatocellular carcinoma (HCC) diagnosis at agent−enhanced US. However, knowledge authors, diagnostic system in characterization liver nodules 20 mm or smaller has not been fully evaluated. Purpose To evaluate CEUS LI-RADS diagnosing HCC patients risk for HCC. Materials Methods Between January 2015 February 2018, consecutive...
Previous evidence has highlighted M2 macrophage regulation of cancer cells via exosome shuttling microRNAs (miRNAs or miRs). The current study set out to explore the possible role macrophage-derived exosomal miR-155-5p in regard immune escape colon cells. Experimental data from quantitative reverse-transcriptase PCR (qRT-PCR) and western blot analysis revealed highly expressed interleukin (IL)-6 poorly ZC3H12B exosomes. Additionally, could be transferred by macrophage-isolated exosomes...
Abstract MicroRNA‐24‐3p (miR‐24‐3p) has been implicated as a key promoter of chemotherapy resistance in numerous cancers. Meanwhile, cancer‐associated fibroblasts (CAFs) can secret exosomes to transfer miRNAs, which mediate tumour development. However, little is known regarding the molecular mechanism CAF‐derived exosomal miR‐24‐3p colon cancer (CC). Hence, this study intended characterize functional relevance CC cell methotrexate (MTX). We identified differentially expressed HEPH, CDX2 and...
Benign prostatic hyperplasia (BPH) is a common issue among older men. Diagnosis of BPH currently relies on imaging tests and assessment urinary flow rate due to the absence definitive diagnostic markers. Developing more accurate markers crucial improve diagnosis.
PURPOSE: To determine if lymphatic channels and sentinel lymph nodes (SLNs) with without metastases can be detected ultrasonography (US) after peritumoral injection of a US contrast agent to used assess SLNs for the presence metastatic infiltration. MATERIALS AND METHODS: Six swine 17 melanomas were evaluated. Conventional gray-scale, color flow, gray-scale phase-inversion harmonic examinations performed. A was administered in four sites around each melanoma (1-mL total dose)....
The subharmonic emission from insonified contrast microbubbles was used to create a new imaging modality called Subharmonic Imaging. response of ultrasound pulses first investigated for determining adequate acoustic transmit parameters. A-lines and gray scale images were then obtained using laboratory pulse-echo system in vitro modified scanner vivo. Excellent suppression all backscattered signals other than achieved while further optimization is required vivo images.
A galactose-based sonographic contrast agent, which produces stable microbubbles capable of traversing the cardiopulmonary circulation, was used to enhance Doppler signals in blood vessels varying size after intravenous injection. series experiments using dogs, rabbits, and woodchucks conducted establish ability agent reflectivity normal tissue, tumor blood. Although no enhancement perceptible tissue on sonogram, significant color spectral demonstrated a variety vessels. These included...