A5017883062- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- interferon and immune responses
- Respiratory viral infections research
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- Gut microbiota and health
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Bioactive natural compounds
- Cancer-related molecular mechanisms research
- Genetic and phenotypic traits in livestock
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Pneumocystis jirovecii pneumonia detection and treatment
- Hepatitis B Virus Studies
- Shoulder and Clavicle Injuries
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Fungal Biology and Applications
- Hepatitis C virus research
- Colorectal Cancer Treatments and Studies
- Inflammasome and immune disorders
Shandong University
2024-2025
Shandong Provincial Hospital
2025
Shandong First Medical University
2025
Institute of Process Engineering
2015-2025
North China Electric Power University
2025
China Electric Power Research Institute
2025
Huaiyin Institute of Technology
2009-2024
Shenzhen Third People’s Hospital
2015-2024
Institute of Soil Science
2014-2024
Hebei Medical University
2017-2024
Abstract SARS-CoV-2 is the pathogen responsible for COVID-19 pandemic. The papain-like cysteine protease (PLpro) has been implicated in playing important roles virus maturation, dysregulation of host inflammation, and antiviral immune responses. multiple functions PLpro render it a promising drug target. Therefore, we screened library approved drugs also examined available inhibitors against PLpro. Inhibitor GRL0617 showed vitro IC 50 2.1 μM an effective inhibition cell-based assays....
Zinc oxide nanoparticles (ZnO NPs) are frequently used in industrial products such as paint, surface coating, and cosmetics, recently, they have been explored biologic biomedical applications. Therefore, this study was undertaken to investigate the effect of ZnO NPs on cytotoxicity, apoptosis, autophagy human ovarian cancer cells (SKOV3).ZnO with a crystalline size 20 nm were characterized various analytical techniques, including ultraviolet-visible spectroscopy, X-ray diffraction,...
Genome-wide association studies (GWAS) have recently identified KIF1B as susceptibility locus for hepatitis B virus (HBV)–related hepatocellular carcinoma (HCC). To further identify novel loci associated with HBV–related HCC and replicate the previously reported association, we performed a large three-stage GWAS in Han Chinese population. 523,663 autosomal SNPs 1,538 HBV–positive patients 1,465 chronic HBV carriers were genotyped discovery stage. Top candidate initial validation samples of...
Chronic gastritis is one of the most common findings at upper endoscopy in general population, and chronic atrophic epidemiologically associated with occurrence gastric cancer. However, current status diagnosis treatment China unclear. A multi-center national study was performed; all patients who underwent diagnostic for evaluation gastrointestinal symptoms from 33 centers were enrolled. Data including sex, age, endoscopic prospectively recorded. Totally 8892 included. At endoscopy, 4389,...
Complement functions as an important host defense system and complement C5 C7 have been implicated in immunopathology of tuberculosis. However, little is known about the role other components tuberculosis.Complement gene expression peripheral blood mononuclear cells tuberculosis patients controls were determined using whole genome transcriptional microarray assays. The mRNA protein levels three C1q components, C1qA, C1qB, C1qC, further validated by qRT-PCR enzyme-linked immunosorbent assay,...
Abstract Dairy goats are one of the most utilized domesticated animals in China. Here, we selected extreme populations based on differential fecundity two Laoshan dairy goat populations. Utilizing deep sequencing have generated 68.7 and 57.8 giga base data, identified 12,458,711 12,423,128 SNPs low high groups, respectively. Following selective sweep analyses, a number loci candidate genes were scanned independently. The reproduction related CCNB2, AR, ADCY1, DNMT3B, SMAD2, AMHR2, ERBB2,...
Mycobacterium tuberculosis infection is associated with a spectrum of clinical outcomes, from long-term latent to different manifestations progressive disease. Pro-inflammatory pathways, such as those controlled by IL-1β, have the contrasting potential both prevent disease restricting bacterial replication, and promote inflicting tissue damage. Thus, ultimate contribution individual inflammatory pathways outcome M. remains ambiguous. In this study, we identified naturally-occurring...
The gut-lung axis has been implicated as a potential therapeutic target in lung disorders. While increasing evidence suggests that gut microbiota plays critical role regulating host immunity and contributing to tuberculosis (TB) development progression, the underlying mechanisms whereby may impact TB outcomes are not fully understood. Here, we found broad-spectrum antibiotics treatment increased susceptibility Mycobacterium (M. tuberculosis) infection modulated pulmonary inflammatory...
The SARS-CoV-2 papain-like protease (PLpro), which has deubiquitinating activity, suppresses the type I interferon (IFN-I) antiviral response. We investigated mechanism by PLpro antagonizes cellular responses. In HEK392T cells, removed K63-linked polyubiquitin chains from Lys 289 of stimulator genes (STING). PLpro-mediated deubiquitination STING disrupted STING-IKKε-IRF3 complex that induces production IFN-β and IFN-stimulated cytokines chemokines. human airway cells infected with...
China, with the third largest share of global tuberculosis cases, faces a substantial challenge in its healthcare system as result high burden multidrug-resistant and rifampicin-resistant (MDR/RR-TB). This study employs genomic epidemiological approach to assess recent transmissions between individuals, identifying potential risk factors discerning role transmitted resistant isolates emergence drug-resistant China.
: Neutrophil elastase has been identified as a potential therapeutic target for acute lung injury or respiratory distress syndrome, and Sivelestat is selective, reversible competitive neutrophil inhibitor. This study was designed to investigate the safety, tolerability, pharmacokinetics inhibitory effects of in healthy Chinese subjects. A randomized, double-blind, placebo-controlled single- multiple-dose escalation clinical trial carried out. Briefly, volunteers twelve cohorts with 8 per...
We reviewed details of Chinese Kimura's disease (KD) cases. A full clinical analysis was subsequently performed to improve the accuracy diagnosis and treatment KD.A total 24 patients with pathologically confirmed KD treated between March 2008 2018 were retrospectively for histopathological analysis.In cases, 20 male 4 female age onset ranging from 5 65 years. Lesion diameter ranged 0.6 cm 7 unilateral involvement being more popular (79%). Imaging examination had a high detection rate...
The outbreaks of 2019 novel coronavirus disease (COVID-19) caused by SARS-CoV-2 infection has posed a severe threat to global public health. It is unclear how the human immune system responds virus infection. Here, we profiled transcriptome signatures metatranscriptome sequencing for bronchoalveolar lavage fluid from eight COVID-19 cases. expression proinflammatory genes, especially chemokines, was markedly elevated in cases as compared community-acquired pneumonia patients and healthy...
Type I interferons (IFN), best known for their anti-viral functions, have been shown to impair host resistance intracellular bacteria in mice. However, the precise role of type IFN signaling bacterial infection humans is unclear. Here, we show that genetic variation human IFNAR1 gene associated with decreased susceptibility tuberculosis and an increased risk viral hepatitis Chinese populations. Receptor mutagenesis cell studies establish mutation corresponding a proline deletion hinge region...
Characterization of the lung microbiota could lead to a better understanding pathogenesis pulmonary TB. Here, we applied metagenomic shotgun sequencing instead 16S rRNA method characterize using BALF samples sputum.