A5043451040- CRISPR and Genetic Engineering
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Cancer-related molecular mechanisms research
- Animal Virus Infections Studies
- Radiomics and Machine Learning in Medical Imaging
- Mycobacterium research and diagnosis
- RNA modifications and cancer
- Gut microbiota and health
- Tuberculosis Research and Epidemiology
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- COVID-19 Clinical Research Studies
- Autism Spectrum Disorder Research
- Pluripotent Stem Cells Research
- Virus-based gene therapy research
- Genetic factors in colorectal cancer
- Cancer Cells and Metastasis
- Clostridium difficile and Clostridium perfringens research
- Gastrointestinal Tumor Research and Treatment
- Crystallization and Solubility Studies
- Atherosclerosis and Cardiovascular Diseases
- Genetics and Neurodevelopmental Disorders
- X-ray Diffraction in Crystallography
- Antibiotic Resistance in Bacteria
Jiangsu University
2024-2025
Pudong Medical Center
2019-2025
Fudan University
2010-2025
Chinese Center For Disease Control and Prevention
2018-2025
Qingdao Center of Resource Chemistry and New Materials
2025
Fuzhou University
2023-2024
Huashan Hospital
2008-2024
Montreal Neurological Institute and Hospital
2022-2024
McGill University
2022-2024
Fudan University Shanghai Cancer Center
2023-2024
The emerging new VOC B.1.1.529 (Omicron) variant has raised serious concerns due to multiple mutations, reported significant immune escape, and unprecedented rapid spreading speed. Currently, studies describing the neutralization ability of different homologous heterologous booster vaccination against Omicron are still lacking. In this study, we explored immunogenicity COVID-19 breakthrough patients, BBIBP-CorV group BBIBP-CorV/ZF2001 SARS-CoV-2 pseudotypes corresponding prototype, Beta,...
Abstract Background N6-Methyladenosine (m6A) modification has been implicated in multiple processes for colon cancer development. IGF2BP3 was a newly reported m6A reader, whereas its role remains unclear. Methods The expression of associated enzymes and total level were measured by Western Blotting analysis RNA Methylation Quantification Kit respectively. Cell cycle analyzed flowcytometry. interaction related targets immunoprecipitation (RIP) (MeRIP) assays. Results We investigated all...
This study examined the impact of oral exposure to antibiotic-resistant bacteria and antibiotic administration methods on resistance (AR) gene pools profile resistant in host gastrointestinal (GI) tracts using C57BL/6J mice with natural gut microbiota. Mice inoculated a mixture tet(M)-carrying Enterococcus spp. or blaCMY-2-carrying Escherichia coli were treated different doses tetracycline hydrochloride (Tet) ampicillin sodium (Amp) delivered via either feed intravenous (i.v.) injection....
Abstract Increasing evidence has indicated a close association between immune infiltration in cancer and clinical outcomes. However, related research thyroid is still deficient. Our comprehensively investigated the of cancer. Data derived from TCGA GEO databases were analyzed by CIBERSORT, ESTIMATE, EPIC algorithms. The CIBERSORT algorithm calculates proportions 22 types cells. ESTIMATE stromal score to represent all cells cancer-associated fibroblasts (CAFs) endothelial (ECs), which are...
As a member of Sirtuins family, SIRT6 participates in the physiological and pathological progress DNA repair, anti-aging, metabolism, so on. Several studies have demonstrated that knockdown inhibited development atherosclerosis (AS), indicated as protective factor for AS. However, we confirmed was significantly overexpressed human unstable carotid plaques compared with stable plaques. This result more complex role Furthermore, constructed mice model plaque injected them adeno-associated...
A COVID-19 booster vaccination is being comprehensively evaluated globally due to the emerging concern of reduced protection rate previous and circulating Variants Concern (VOC). But safety immunogenicity homologous BBIBP-CorV boosting are yet be thoroughly evaluated. We conducted this prospective, open-label study in Huashan Hospital using a third 6.5U administered at an interval 4–8 months following two doses healthy adults. Safety, anti-RBD response neutralizing titers against SARS-CoV-2...
Summary Hepatitis E virus (HEV) is a zoonotic pathogen of which several species animal were reported as reservoirs. Antibodies to HEV and RNA have been detected in some Chinese population swine groups but few other domestic animals. In this study, investigate the prevalence, we tested sera from 788 pigs, 100 cows, 50 goats, 49 horses, 101 pet dogs, 105 chickens, 47 duck 45 pigeons eastern China for anti‐HEV immunoglobulin G (IgG). We also 50% sera, all animals 13 Shanghai human positive M...
Abstract Genetically modified nonhuman primates (NHP) are useful models for biomedical research. Gene editing technologies have enabled production of target-gene knock-out (KO) NHP models. Target-gene-KO/knock-in (KI) efficiency CRISPR/Cas9 has not been extensively investigated in marmosets. In this study, optimum conditions target gene modification efficacies CRISPR/mRNA and CRISPR/nuclease marmoset embryos were examined. was more effective than avoiding mosaic genetic alteration....
Abstract Interleukin‐33 (IL‐33) and its receptor ST2 contribute to spinal glial activation chronic pain. A recent study showed that peripheral IL‐33 plays a pivotal role in the pathogenesis of itch induced by poison ivy. However, how IL‐33/ST2 signaling cord potentially mediates remains elusive. Here, we determined St2 −/− substantially reduced scratching behaviors 2,4‐dinitrofluorobenzene (DNFB)‐induced allergic contact dermatitis (ACD) as well acetone diethylether followed water‐induced...
Abstract Ferroptosis has been confirmed to be associated with various diseases, but the relationship between ferroptosis and atherosclerosis (AS) remains unclear. Our research detailly clarified roles of in three continuous main pathological stages AS respectively (injury endothelial cells [ECs], adhesion monocytes, formation foam cells). We that oxidized low‐density lipoprotein (ox‐LDL), key factor pathogenesis AS, strongly induced ECs. Inhibition repressed monocytes ECs by inhibiting...
Pancreatic cancer is amongst the most lethal malignancies with increasing incidence and mortality worldwide. Distant metastases, especially intrahepatic leading cause of death for pancreatic cancer. Circulating tumor cells (CTCs) are neoplastic released from primary into circulation, play critical roles in metastases various types cancers. Though clinical studies showed that detection CTCs peripheral circulation was associated worse prognosis patients breast hepatocellular carcinoma, blood...
Reactive changes of glial cells during neuroinflammation impact brain disorders and disease progression. Elucidating the mechanisms that control reactive gliosis may help us to understand pathophysiology improve outcomes. Here, we report adult ablation autism spectrum disorder (ASD)-associated CHD8 in astrocytes attenuates via remodeling chromatin accessibility, changing gene expression. Conditional Chd8 deletion astrocytes, but not microglia, suppresses by impeding astrocyte proliferation...