A5025141398- Dermatology and Skin Diseases
- Ion Channels and Receptors
- Pain Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacological Effects of Natural Compounds
- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Acupuncture Treatment Research Studies
- Urticaria and Related Conditions
- Exercise and Physiological Responses
- Eosinophilic Esophagitis
- Cardiac Fibrosis and Remodeling
- Phytochemicals and Antioxidant Activities
- Allergic Rhinitis and Sensitization
- Cardiac Structural Anomalies and Repair
- Tissue Engineering and Regenerative Medicine
- Neuroscience and Neuropharmacology Research
- Olfactory and Sensory Function Studies
- Plant-based Medicinal Research
- Nicotinic Acetylcholine Receptors Study
- Lung Cancer Treatments and Mutations
- Acute Lymphoblastic Leukemia research
- Liver Disease and Transplantation
- Sphingolipid Metabolism and Signaling
- Gout, Hyperuricemia, Uric Acid
Shanghai University of Traditional Chinese Medicine
2022-2024
Shanghai Medical College of Fudan University
2021-2024
State Key Laboratory of Medical Neurobiology
2017-2024
The First People's Hospital of Shunde
2024
Washington University in St. Louis
2020-2023
Washington Center
2023
Fudan University
2017-2022
Air Force Medical University
2021
Instituto Medicina Integrativa (Portugal)
2021
Integrative Medicine Institute
2021
Microglia, resident macrophages of the CNS, are essential to brain development, homeostasis, and disease. Microglial activation proliferation hallmarks many CNS diseases, including neuropathic pain. However, molecular mechanisms that govern spinal neuroimmune axis in setting pain remain incompletely understood. Here, we show genetic ablation or pharmacological blockade transient receptor potential vanilloid type 4 (TRPV4) markedly attenuated pain-like behaviors a mouse model spared nerve...
Crystal structures activate innate immune cells, especially macrophages and initiate inflammatory responses. We aimed to understand the role of mechanosensitive TRPV4 channel in crystal-induced inflammation. Real-time RT-PCR, RNAscope situ hybridisation, Trpv4 eGFP mice were used examine expression whole-cell patch-clamp recording live-cell Ca 2+ imaging study function mouse synovial human peripheral blood mononuclear cells (PBMCs). Both genetic deletion pharmacological inhibition approaches...
Abstract Aims We investigated the potential mechanisms underlying therapeutic efficacy of electroacupuncture (EA) at Shuigou (GV26) and Baihui (GV20) acupoints in treatment ischemic stroke. Methods assessed effects EA on MCAO mice through behavioral studies TTC staining. Various techniques, such as RT‐PCR, immunofluorescence, Western blots, were employed to evaluate activation polarization microglia/macrophages, changes TRPV4 ion channel. used antagonist GSK2193874 (GSK219) verify...
Abstract Interleukin‐33 (IL‐33) and its receptor ST2 contribute to spinal glial activation chronic pain. A recent study showed that peripheral IL‐33 plays a pivotal role in the pathogenesis of itch induced by poison ivy. However, how IL‐33/ST2 signaling cord potentially mediates remains elusive. Here, we determined St2 −/− substantially reduced scratching behaviors 2,4‐dinitrofluorobenzene (DNFB)‐induced allergic contact dermatitis (ACD) as well acetone diethylether followed water‐induced...
BACKGROUND: Exercise has been proven to be an efficient intervention in attenuating neuropathic pain. However, the underlying mechanisms that drive exercise analgesia remain unknown. In this study, we aimed examine role of complement component 3 (C3) pain and whether antinociceptive effects are produced by via regulating C3 mice. METHODS: using a spared nerve injury (SNI)-induced mice model, C57BL/6J were divided into groups: Sham mice, SNI + (Ex) with 30-minute low-intensity aerobic...
Abstract Background Epithelial cells ( EC s) play a crucial role in allergic sensitization to inhaled protease allergens by instructing type 2 innate lymphoid ILC 2) and dendritic DC via release of pro‐type cytokines, particularly interleukin‐33 IL ‐33). Leukotriene B4 LTB 4) is well‐known leukocyte chemoattractant engagement its receptor 1 BLT 1). However, the 4‐ axis activation s still unknown. Methods We evaluated effect on ‐33 expression vivo vitro. Chimeric mice were established...
Blocking opioid-induced chemokine release from astrocytes may improve long-term pain management.
Electroacupuncture (EA) at Shuigou (GV26) and Baihui (GV20) has shown therapeutic benefits for stroke patients. Given that natural killer (NK) cell infiltration into the brain significantly contributes to exacerbation of cerebral ischemic injury, this study investigated impact EA on post-ischemic activation NK cells.
Acupoint catgut embedding (ACE) is a widely used traditional Chinese medicine method to manage various diseases, including chronic inflammatory pain. We sought assess the possible analgesic effects of ACE in comparison with electroacupuncture (EA) and study mechanisms rat model pain induced by injection complete Freund's adjuvant (CFA) into hind paw rats. The von Frey, radiant heat, gait analysis tests were performed evaluate EA, Western blot immunohistochemistry assays carried out determine...
Cold allodynia is a common complaint of patients suffering from neuropathic pain initiated by peripheral nerve injury. However, the mechanisms that drive cold remain elusive. In this study, we show interleukin (IL)-33/ST2 signaling in dorsal root ganglion (DRG) critical contributor to interacting with sensor transient receptor potential melastatin 8 (TRPM8). By using St2-/- mice, demonstrate ST2 required for generation nociceptor hyperexcitability and mouse model spared injury (SNI)....
The Albumin-Bilirubin (ALBI) score has been widely used to assess the prognosis in patients with cirrhosis and hepatocellular carcinoma. This study aimed analyze relationship between ALBI all-cause mortality hepatitis B virus (HBV) infection general. Patients aged ≥ 18 years previous or current HBV from National Health Nutrition Examination Survey (NHANES) United States 1999 2018 were enrolled this retrospective cohort study. Weight univariate multivariate Cox regression models mortality....
Hair follicle telogen to anagen transition results in a break cellular quiescence of the hair stem cells, which subsequently promotes regeneration. Many critical molecules and signalling pathways are involved cycle progression. Transient receptor potential vanilloid 4 (TRPV4) is polymodal sensory transducer that regulates various cutaneous functions under both normal disease conditions. However, role TRPV4 regeneration vivo remains incompletely understood.Using adult C57BL/6J mice,...
Microglia are found pathologically at all stages of multiple sclerosis (MS) lesion development and hypothesized to contribute both inflammatory injury neuroprotection in the MS brain. Transient receptor potential vanilloid 4 (TRPV4) channels widely expressed, play an important role as environmental sensors, involved calcium homeostasis for a variety cells. TRPV4 modulates myeloid cell phagocytosis periphery microglial motility central nervous system. We that deletion would alter microglia...