A5007517701- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- EEG and Brain-Computer Interfaces
- Advanced Memory and Neural Computing
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Neuroscience and Neural Engineering
- Acupuncture Treatment Research Studies
- Neuroendocrine regulation and behavior
- Blind Source Separation Techniques
- Pain Mechanisms and Treatments
- interferon and immune responses
- Ion channel regulation and function
- Neural and Behavioral Psychology Studies
- Eicosanoids and Hypertension Pharmacology
- Inflammatory mediators and NSAID effects
- Epilepsy research and treatment
- Alzheimer's disease research and treatments
- Photoreceptor and optogenetics research
- Estrogen and related hormone effects
- Neurogenesis and neuroplasticity mechanisms
- Genomics and Phylogenetic Studies
- Psychosomatic Disorders and Their Treatments
- Sentiment Analysis and Opinion Mining
Shanghai University of Traditional Chinese Medicine
2018-2025
Chinese Academy of Sciences
2011-2022
Institute of Hydrobiology
2022
Guangdong University of Foreign Studies
2022
Shanghai Institute of Materia Medica
2021
Augusta University
2009-2018
Discovery Institute
2009-2018
Augusta University Health
2017
Shenzhen Institutes of Advanced Technology
2016
Monash Institute of Medical Research
2013
Abstract Aims We investigated the potential mechanisms underlying therapeutic efficacy of electroacupuncture (EA) at Shuigou (GV26) and Baihui (GV20) acupoints in treatment ischemic stroke. Methods assessed effects EA on MCAO mice through behavioral studies TTC staining. Various techniques, such as RT‐PCR, immunofluorescence, Western blots, were employed to evaluate activation polarization microglia/macrophages, changes TRPV4 ion channel. used antagonist GSK2193874 (GSK219) verify...
One major theory in learning and memory posits that the NR2B gene is a universal genetic factor acts as rate-limiting molecule controlling optimal NMDA receptor's coincidence-detection property subsequent function across multiple animal species. If so, can be enhanced via transgenic overexpression of another species other than previously reported mouse species? To examine these crucial issues, we generated rats which overexpressed cortex hippocampus investigated role receptor-mediated...
Abstract The hippocampal CA3 contributes to spatial working memory (SWM), but which stage of SWM the neurons act on and whether lateralization function occurs in is also unknown. Here, we reveal increased neural activity both sample choice phases SWM. Left (LCA3) show higher sensitivity phase during correct versus error trials compared with right (RCA3) neurons. LCA3 initiates firing prior RCA3 phase. Optogenetic suppression pyramidal disrupts only Furthermore, discover that parvalbumin (PV)...
Clinical evidences indicate that multifaceted gait abnormalities may manifest in Alzheimer's disease (AD) patients, which are associated with cognitive decline. Although the correlation between hippocampal theta power and locomotion has been known for a long time, mechanisms by how impairment participates altered seen AD is not fully understood. To explore manifestations of disorders AD, we characterized performance 3-, 6-, 9-month-old male 5xFAD control mice semi-automated, highly...
Chromosomal evolution in carnivores has been revisited extensively using cross-species chromosome painting. Painting probes derived from flow-sorted chromosomes of the domestic dog, which one most rearranged karyotypes mammals and highest dipoid number (2n=78) carnivores, are a powerful tool detecting both evolutionary intra- inter-chromosomal rearrangements. However, only few comparative maps have established between dog other non-Canidae species. Here, we extended painting with to seven...
Emerging evidence shows that disrupted gut microbiota-bile acid (BA) axis is critically involved in the development of neurodegenerative diseases. However, alterations spatial distribution BAs among different brain regions command important functions during aging and their exact roles aging-related diseases are poorly understood. Here, we analyzed BA profiles cerebral cortex, hippocampus, hypothalamus young natural mice both sexes. The results showed altered sex- region- dependently, which...
Alzheimer's disease (AD) is a typical neurodegenerative that leads to irreversible neuronal degeneration, and effective treatment remains elusive due the unclear mechanism. We utilized biocompatible mesenchymal stem cell-derived extracellular vesicles as carriers loaded with CB2 target medicine AM1241 (EVs-AM1241) protect against progression function in AD model mice. According results, EVs-AM1241 were successfully constructed exhibited better bioavailability therapeutic effects than bare...
Squamous cell lung cancer (SqCC) is the second most common type of in United States. Previous studies have used gene-expression data to classify SqCC samples into four subtypes, including primitive, classical, secretory and basal subtypes. These subtypes different survival outcomes, although it unknown whether these molecular predict response therapy. Here, we analysed RNAseq 178 tumour characterised features define signature genes pathway alterations specific each subtype. Further, compared...
River cetaceans are particularly vulnerable to anthropogenic impacts due their constrained ranges in freshwater systems of China, South Asia, and America. We undertook an exhaustive review 280 peer-reviewed papers grey literature reports (1998-2020) examine the current status knowledge regarding these conservation. aimed better understand scale threats they face, identify propose priority future efforts conserve species. found that species have been studied with varying frequency most...
The N -methyl-D-aspartate (NMDA) receptor is known to be necessary for many forms of learning and memory, including social recognition memory. Additionally, the GluN2 subunits are modulate multiple with a high GluN2A:GluN2B ratio leading impairments in long-term while low enhances some Here, we investigate molecular motif responsible differences memory olfactory forebrain-specific transgenic GluN2A overexpression mice GluN2B by using two mouse lines that overexpress chimeric subunits....
Although the functions of alpha-Ca(2+)/calmodulin-dependent kinase II (CaMKII) have been studied extensively, role betaCaMKII, a coconstituent CaMKII holoenzyme in synaptic plasticity, learning, and memory has not examined vivo. Here we produce transgenic mouse line which inducible reversible manipulation betaCaMKII activity is restricted to hippocampal dentate gyrus, region where long-term potentiation was originally discovered. We demonstrate that gyrus selectively impaired perforant path,...
The opening-duration of the NMDA receptors implements Hebb's synaptic coincidence-detection and is long thought to be rate-limiting factor underlying superior memory. Here, we investigate molecular genetic determinants by testing "synaptic time-duration" hypothesis vs. "GluN2B intracellular signaling domain" hypothesis. Accordingly, generated a series GluN2A, GluN2B, GluN2D chimeric subunit transgenic mice in which C-terminal domains were systematically swapped overexpressed forebrain...
While deep learning algorithms significantly improves the decoding performance of brain-computer interface (BCI) based on electroencephalogram (EEG) signals, relies a large number high-resolution data for training. However, collecting sufficient usable EEG is difficult due to heavy burden subjects and high experimental cost. To overcome this insufficiency, novel auxiliary synthesis framework first introduced in paper, which composes pre-trained model generative model. The learns latent...
Cytoplasmic dynein is an important intracellular motor protein that plays role in neuronal growth, axonal polarity formation, dendritic differentiation, and spine development among others. The intermediate chain of dynein, encoded by Dync1i1, a vital the complex. Therefore, we assessed behavioral related activities mice with dync1i1 gene knockout. Neuronal primary somatosensory cortex were recorded vivo electrophysiology manipulated optogenetic chemogenetics. Nociception mechanical, thermal,...
Abstract It is generally accepted that Cyclooxygenase‐2 (COX‐2) activated to cause inflammation. However, COX‐2 also constitutively expressed at the postsynaptic dendrites and excitatory terminals of cortical spinal cord neurons. Although some evidence suggests release during neuronal signalling may be pivotal for regulating function memory, significance in neuron still unclear. This research aims discover role memory beyond neuroinflammation determine whether inhibition can cognitive...
Electroacupuncture (EA) at Shuigou (GV26) and Baihui (GV20) has shown therapeutic benefits for stroke patients. Given that natural killer (NK) cell infiltration into the brain significantly contributes to exacerbation of cerebral ischemic injury, this study investigated impact EA on post-ischemic activation NK cells.