A5077764391- Cancer-related molecular mechanisms research
- Sarcoma Diagnosis and Treatment
- RNA Research and Splicing
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Bone Tumor Diagnosis and Treatments
- Cancer Immunotherapy and Biomarkers
- Healthcare professionals’ stress and burnout
- Wound Healing and Treatments
- Spinal Cord Injury Research
- Mesenchymal stem cell research
- Extracellular vesicles in disease
- Molecular Biology Techniques and Applications
- Burn Injury Management and Outcomes
- Cancer, Lipids, and Metabolism
- Innovations in Medical Education
- Empathy and Medical Education
- Spine and Intervertebral Disc Pathology
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Educational Environments and Student Outcomes
- Prostate Cancer Treatment and Research
- Cancer Cells and Metastasis
- Oral and Maxillofacial Pathology
- Musculoskeletal synovial abnormalities and treatments
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Second Military Medical University
2023-2025
Shanghai Jiao Tong University
2025
Shanghai First People's Hospital
2022-2025
Changhai Hospital
2025
Tongji University
2019-2024
Tongji Hospital
2019-2024
Hangzhou First People's Hospital
2024
Zhejiang University
2024
Shanghai Tenth People's Hospital
2023-2024
Spinal cord injury (SCI) involves diverse responses in different cell types a temporally and spatially specific manner. Here, using single-cell transcriptomic analyses combined with classic anatomical, behavioral, electrophysiological analyses, we report, resolution, temporal molecular cellular changes crush-injured adult mouse spinal cord. Data revealed pathological of 12 major types, three which infiltrated into the at distinct times post-injury. We discovered novel microglia astrocyte...
Intervertebral disc degeneration (IVDD) is a significant cause of global disability, reducing labor productivity, increasing the burden on public health, and affecting socio-economic well-being. Currently, there lack recognized clinical approaches for molecular classification precision therapy. Chondrocyte differentiation prognosis-related genes were extracted from single-cell RNA sequencing multi-omics data in Gene Expression Omnibus (GEO) database through chondrocyte trajectory analysis...
Empathy of medical students is crucial, yet it tends to decline as enter later academic years. appeared be affected by the learning environment (LE), which could a potential contributor. We conducted cross-sectional study investigate association between LE and empathy. The comprised overall 10,901 from 12 Chinese schools. Jefferson Scale (JSE) was utilized assess empathy, while 5-point question Johns Hopkins Learning Environment were employed evaluate LE. JSE scores compared across levels...
Background: Kidney renal clear cell carcinoma (KIRC) is the malignancy originated from epithelium, with a high rate of distant metastasis. Aberrant alternative splicing (AS) pre-mRNA are widely reported to be involved in tumorigenesis and metastasis multiple cancers. The aim this study explore mechanism events (ASEs) underlying KIRC. Methods: RNA-seq 537 KIRC samples downloaded TCGA database ASEs data TCGASpliceSeq were used identify patients univariate Lasso regression analysis screen most...
Subclassification of tumors based on molecular features may facilitate therapeutic choice and increase the response rate cancer patients. However, highly complex cell origin involved in osteosarcoma (OS) limits utility traditional bulk RNA sequencing for OS subclassification. Single-cell (scRNA-seq) holds great promise identifying heterogeneity. this technique has rarely been used study tumor By analyzing scRNA-seq data six conventional nine cancellous bone (CB) samples, we identified 29...
Background: Colon adenocarcinoma (COAD) is a fatal and malignant tunor in digestive system distance metastasis lead to poor prognosis. The metastasis-specific ceRNAs (competitive endogenous RNAs) tumor-infiltrating immune cells might associate with tumor prognosis metastasis. Nonetheless, few studies have concentrated on Immune COAD. Methods: gene expression profile clinical information of COAD were downloaded from TCGA divided into two groups: primary tumors or without We applied...
Tetraspanins (TSPANs) are a class of four-transmembrane segmented proteins. The precise functions TSPANs and their roles in pan-cancer unclear. In this work, we analyzed TSPAN1, TSPAN10, TSPAN11, TSPAN12, TSPAN13, TSPAN14, TSPAN15, TSPAN16, TSPAN17, TSPAN18, TSPAN18-AS1, TSPAN19, TSPAN2, TSPAN3, TSPAN31, TSPAN32, TSPAN33, TSPAN4, TSPAN5, TSPAN6, TSPAN7, TSPAN8, TSPAN9, TSPAN9-IT1 (24 TSPAN family genes) relation to tumor characteristics from 11,057 TCGA samples across 33 cancer types. On 24...
Background Rheumatoid Diseases (RDs) are a group of systemic auto-immune diseases that characterized by chronic synovitis, and fibroblast-like synoviocytes (FLSs) play an important role in the occurrence progression synovitis. Our study is first to adopt bibliometric analysis identify global scientific production visualize its current distribution 21st century, providing insights for future research through themes keywords. Methods We obtained publications from core collection Web Science...
Soft tissue sarcoma (STS) is one of the most challenging tumors for medical oncologists, with a high rate recurrence after initial resection. In this study, recurrent STS-specific competitive endogenous RNA (ceRNA) network including seven and overall survival (OS)-associated genes (LPP-AS2, MUC1, GAB2, hsa-let-7i-5p, hsa-let-7f-5p, hsa-miR-101-3p hsa-miR-1226-3p) was established based on gene expression profiling 259 primary sarcomas 3 local samples from TCGA database. The algorithm "cell...
The reclassification of Papillary Thyroid Carcinoma (PTC) is an area research that warrants attention. connection between thyroid cancer, inflammation, and immune responses necessitates considering the mechanisms differential prognosis tumors from immunological perspective. Given high adaptability macrophages to environmental stimuli, focusing on differentiation characteristics might offer a novel approach address issues related PTC subtyping. Single-cell RNA sequencing data medullary cells...
TSPAN7 is an important factor in tumor progression. However, the precise function of and its role pan-cancer are not clear. Based on Xinhua cohort incorporating 370 patients with kidney neoplasm, we conducted differential expression analysis by immunohistochemistry between normal tissues, explored correlations patients' survival. Subsequently, a study, successively employed analysis, competing endogenous RNA (ceRNA) protein-protein interaction (PPI) correlation clinical characteristics,...
Burns lead to systemic changes manifested by disturbances in water-electrolyte balance and metabolic inflammatory responses. The hypermetabolic response after a burn injury relies on metabolic, hormonal, dysregulation mechanisms. This study aimed provide comprehensive bibliometric analysis of the metabolism research field, identifying key trends, influential contributors, emerging hotspots inform future investigative efforts. Ultimately, we conducted an extensive review literature,...
Burn injuries often leave behind a "stasis zone", region of tissue critically important for determining both the severity injury and potential recovery. To understand intricate cellular epigenetic changes occurring within this critical zone, we utilized single-cell assay transposase-accessible chromatin sequencing (scATAC-seq) to profile over 31,500 cells from healthy rat skin stasis zone at nine different time points after burn injury. This comprehensive approach revealed 26 distinct cell...
Medical school learning environment (MSLE) is highly related to medical students' academic performance. However, the grade point average (GPA) rankings have not been studied together with MSLE. We aim figure out relationship between GPA and gathered data from 12 schools in mainland China, employing Johns Hopkins Learning Environment Scale (JHLES) assess subjective perceptions of Subsequently, we performed a cross-sectional study examining JHLES scores. conducted Pearson's Chi-square test...
Renal cell carcinoma (RCC) is a heterogeneous malignancy with diverse gene expression patterns, molecular landscapes, and differentiation characteristics of tumor cells. It imperative to develop RCC classification based on for precise risk stratification personalized therapy. We obtained scRNA-seq profiles from GSE159115 bulk RNA-seq TCGA-KIRC cohort. then performed cluster analysis, monocle2 pseudotime prognostic analysis obtain differentiation-related genes (TCDGs). Subsequently, we...