A5049698294- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Sarcoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Liver Disease Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Bone Tumor Diagnosis and Treatments
- Cancer, Lipids, and Metabolism
- Musculoskeletal synovial abnormalities and treatments
- Sepsis Diagnosis and Treatment
- Hepatitis B Virus Studies
- Nitric Oxide and Endothelin Effects
- Immune Response and Inflammation
- Glioma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Mycobacterium research and diagnosis
- Cancer Immunotherapy and Biomarkers
- Extracellular vesicles in disease
- Occupational and environmental lung diseases
The Ohio State University
2015-2025
Dalian Medical University
2025
Chongqing Medical University
2025
Second Affiliated Hospital of Chongqing Medical University
2025
Shanghai Tenth People's Hospital
2014-2024
Tongji University
2014-2024
Kunming University of Science and Technology
2008-2024
Shanghai Changzheng Hospital
2024
First Affiliated Hospital of Zhengzhou University
2019-2023
Second Xiangya Hospital of Central South University
2023
Dysregulated lipid metabolism is a characteristic of malignancies. Sterol regulatory element binding protein 1 (SREBP-1), transcription factor playing central role in metabolism, highly activated Here, we unraveled link between miR-29 and the SCAP (SREBP cleavage-activating protein)/SREBP-1 pathway glioblastoma (GBM) growth. Epidermal growth receptor (EGFR) signaling enhances expression GBM cells via upregulation SCAP/SREBP-1, SREBP-1 activates to specific sites its promoter. In turn,...
Background: Kidney renal clear cell carcinoma (KIRC) is the malignancy originated from epithelium, with a high rate of distant metastasis. Aberrant alternative splicing (AS) pre-mRNA are widely reported to be involved in tumorigenesis and metastasis multiple cancers. The aim this study explore mechanism events (ASEs) underlying KIRC. Methods: RNA-seq 537 KIRC samples downloaded TCGA database ASEs data TCGASpliceSeq were used identify patients univariate Lasso regression analysis screen most...
Introduction Yunnan Xiaomila is a pepper variety whose flowers and fruits become mature at the same time multiple times year. The distinction between background low complex. targets are small difficult to identify. Methods This paper aims problem of target detection under complex environment, in order reduce impact caused by color gradient changes xiaomila unclear feature information, an improved PAE-YOLO model proposed, which combines EMA attention mechanism DCNv3 deformable convolution...
It is well established that the liver-specific miR-122, a bona fide tumor suppressor, plays critical role in lipid homeostasis. However, its role, if any, amino acid metabolism has not been explored. Since glutamine (Gln) energy and anaplerotic source for mammalian cells, we assessed Gln control wild type (WT) mice miR-122 knockout (KO) by stable isotope resolved metabolomics (SIRM) studies. Six-to eight-week-old WT KO 12- to 15-month-old liver tumor-bearing were injected with...
Exemestane, a steroidal aromatase inhibitor prescribed for post-menopausal women with estrogen receptor-positive breast cancer, is associated debilitating musculoskeletal side effects and exhibits considerable interindividual variability in systemic exposure. Although exemestane metabolized mainly by cytochrome P-450 3A4, the contribution of this metabolic pathway to elimination its drug–drug interaction liabilities remains uncertain. Here, we developed novel quantification method applied it...
<div>Impact resistance is crucial for assessing charging pile safety and reliability. This study proposes a prediction model, called GA-BP neural network, which achieved errors below 5% reduced computation time by over 95% in comparison to finite element analysis (FEA). Initially, the impact test platform constructed, matching simulation model developed. The correctness of then verified integrating experimental findings. Furthermore, Latin hypercube approach used create 200 sets...
<div>For the heat dissipation design of charging equipment for electric vehicles, a study is conducted on thermal performance and its influencing factors specific alternating current (AC) device. First, based theory CFD simulation software, corresponding finite element model established verified through experiments. Next, using applying orthogonal experimental method, AC pile, such as ambient temperature, output surface radiation characteristics, are investigated. Finally, prediction...
<div>This article takes the cover of AC charging pile as research object and studies process parameters dual-color injection molding. First, optimal Latin hypercube experimental design is carried out by using optimization software taking melt temperature mold first shot second holding pressure influencing factors. Injection simulation based on flow software. A high-precision neural network model RBF constructed according to test factors results. Second, obtained prediction model,...
Soft tissue sarcoma (STS) is one of the most challenging tumors for medical oncologists, with a high rate recurrence after initial resection. In this study, recurrent STS-specific competitive endogenous RNA (ceRNA) network including seven and overall survival (OS)-associated genes (LPP-AS2, MUC1, GAB2, hsa-let-7i-5p, hsa-let-7f-5p, hsa-miR-101-3p hsa-miR-1226-3p) was established based on gene expression profiling 259 primary sarcomas 3 local samples from TCGA database. The algorithm "cell...
Given the opposing effects of Akt and AMP-activated protein kinase (AMPK) on metabolic homeostasis, this study examined deletion Akt2 AMPKα2 fat diet-induced hepatic steatosis. Akt2-Ampkα2 double knockout (DKO) mice were placed high diet for 5 months. Glucose metabolism, energy cardiac function, lipid accumulation, steatosis examined. DKO lean without anthropometric defects. High intake led to adiposity decreased respiratory exchange ratio (RER) in wild-type (WT) mice, which ablated but not...
The addition of darolutamide, an androgen receptor signalling inhibitor, to therapy with docetaxel has recently been approved as a strategy treat metastatic prostate cancer. OATP1B3 is SLC transporter that highly expressed in cancer and responsible for the accumulation substrates, including docetaxel, into tumours. Given darolutamide inhibits vitro, we sought characterise impact on pharmacokinetics. We investigated influence transport using vitro vivo models. assessed tumour patient-derived...
Background: Mesothelioma is a rare and aggressive tumor. Bone metastasis often occurs in the later stages of this disease along with poor quality life. Thus, it important to explore tumorigenesis bone mechanism invasive mesothelioma. For purpose, we established two nomograms based on tumor-infiltrating immune cells ceRNA networks describe molecular immunity clinical prediction mesothelioma patients metastasis. Method: The expression profiles mRNAs, lncRNAs, miRNAs 87 primary mesotheliomas...
Hepatocellular carcinoma (HCC), the most prevalent primary liver cancer, is a leading cause of cancer-related death worldwide because rising incidence and limited therapy. Although treatment with sorafenib or lenvatinib standard care in patients advanced-stage HCC, survival benefit from due to low response rate drug resistance. Ibrutinib, an irreversible tyrosine kinase inhibitor (TKI) TEC (e.g., BTK) ErbB EGFR) families, approved for B-cell malignancies. Here, we demonstrate that ibrutinib...