A5090257502- Autophagy in Disease and Therapy
- Cardiac Fibrosis and Remodeling
- Mitochondrial Function and Pathology
- Chemotherapy-induced cardiotoxicity and mitigation
- Berberine and alkaloids research
- Diabetes Treatment and Management
- Electron Spin Resonance Studies
- Cardiovascular Function and Risk Factors
- Liver physiology and pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genetics, Aging, and Longevity in Model Organisms
- Sirtuins and Resveratrol in Medicine
- Cancer Cells and Metastasis
- Renin-Angiotensin System Studies
- Drug Transport and Resistance Mechanisms
- Redox biology and oxidative stress
- Inflammasome and immune disorders
- Cardiovascular Effects of Exercise
- Diamond and Carbon-based Materials Research
- Fuel Cells and Related Materials
- Glutathione Transferases and Polymorphisms
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Ubiquitin and proteasome pathways
- Ferroptosis and cancer prognosis
Shanghai Xuhui Central Hospital
2020-2025
Fudan University
2020-2025
Zhongshan Hospital
2025
National Clinical Research Center for Digestive Diseases
2022-2024
Liver fibrosis is a life-threatening pathological anomaly which usually evolves into advanced liver cirrhosis and hepatocellular carcinoma although limited therapeutic option readily available. FUN14 domain containing 1 (FUNDC1) mitophagy receptor with little information in fibrosis. This study was designed to examine the role for FUNDC1 carbon tetrachloride (CCl4)-induced injury. GEO database analysis subsequent validation of biological processes including western blot, immunofluorescence,...
Berberine has been verified to protect cardiac function in patients with heart failure (HF). However, the mechanism(s) involved berberine-mediated cardioprotective effects not clearly elucidated. The aim of this study was further investigate beneficial berberine on transverse aortic contraction (TAC)-induced chronic HF. Mice were randomly divided into four groups. administered at a dose 50 mg/kg/day for 4 weeks via oral gavage. Our findings showed that TAC-induced pressure overload (PO)...
Doxorubicin (DOX) is among the most widely employed antitumor agents, although its clinical applications have been largely hindered by severe cardiotoxicity. Earlier studies described an essential role of mitochondrial injury in pathogenesis DOX cardiomyopathy. PHB2 (Prohibitin 2) perceived as regulator for dynamics and oxidative phosphorylation (OXPHOS) involvement cardiomyopathy remains elusive.To decipher possible cardiomyopathy, tamoxifen-induced cardiac-specific conditional knockout...
Heart failure with preserved ejection fraction (HFpEF) is a devastating health issue although limited knowledge available for its pathogenesis and therapeutics. Given the perceived involvement of mitochondrial dysfunction in HFpEF, this study was designed to examine role dynamics etiology HFpEF.
A comprehensive view of the role NLRP3/caspase-1/GSDMD-mediated pyroptosis in pressure overload cardiac hypertrophy is presented this study. Furthermore, mitigation NLRP3 deficiency-induced confers cardioprotection against through activation TAK1, whereas salutary effect abolished by inhibition TAK1 activity, highlighting a previously unrecognized reciprocally regulatory NLRP3-TAK1 governing inflammation-induced cell death and hypertrophic growth. Translationally, study advocates strategies...
Abstract Mitochondrial aldehyde dehydrogenase (ALDH2) offers proven cardiovascular benefit, although its impact on diabetes remains elusive. This study examined the effects of ALDH2 overexpression and knockout diabetic cardiomyopathy mechanism involved with a focus mitochondrial integrity. Mice challenged streptozotocin (STZ, 200 mg/kg, via intraperitoneal injection) exhibited pathological alterations, including reduced respiratory exchange ratio, dampened fractional shortening ejection...
Aims: Acute myocardial infarction (MI), caused by acute coronary artery obstruction, is a common cardiovascular event leading to mortality. Nuclear dot protein 52 (NDP52) an essential selective autophagy adaptor, although its function in MI still obscure. This study was designed examine the of NDP52 and associated mechanisms. Results: Our results revealed that challenge overtly impaired geometry systolic function, along with cardiomyocyte apoptosis, interstitial fibrosis, mitochondrial...
Clinical application of doxorubicin (DOX) is heavily hindered by DOX cardiotoxicity. Several theories were postulated for cardiotoxicity including DNA damage and response (DDR), although the mechanism(s) involved remains to be elucidated. This study evaluated potential role TBC domain family member 15 (TBC1D15) in Tamoxifen-induced cardiac-specific Tbc1d15 knockout (Tbc1d15CKO) or knockin (Tbc1d15CKI) male mice challenged with a single dose prior cardiac assessment 1 week 4 weeks following...
The study aimed to investigate the influences of aldehyde dehydrogenase 2 (ALDH2) on cardiomyocyte apoptosis in heart failure (HF) rats through regulating PTEN induced putative kinase 1 (PINK1)-Parkin signaling pathway-mediated mitophagy. rat model HF was established, and were randomly divided into group (HF model, n=20) ALDH2 (intervention with ALDH2, n=20), a normal (n=20) set. After successful modeling, MRI ECG applied detect cardiac function indexes rats. myocardial index creatine (CK)...
Background: Inflammation was only recently appreciated in pressure overload-induced cardiac remodeling, while the underlying orchestration of inflammation-induced cell death and hypertrophic growth remains largely unknown. Objective: This study sought to unveil a pivotal role for transforming factor β-activated kinase 1 (TAK1) coordination Nod-like receptor (NLR) family pyrin domain containing 3 (NLRP3)/Caspase-1/Gasdermin D (GSDMD)-mediated pyroptosis (inflammatory death) under overload....
Objectives: To study the prevalence of LVDD and arterial stiffness association with and/or among residents HTN, as well determine whether aging was independently correlated stiffness. This a cross-sectional study, using results from Shanghai Heart Health national project in China. Methods: Using data 2086 participants, we explored associations HTN or without brachial-ankle pulse wave velocity (baPWV). Correlations were analyzed adjusted multivariable logistic models. Results: The proportion...
Background: Inflammation was only recently appreciated in pressure overload-induced cardiac remodeling, while the underlying orchestration of inflammatory cell death and hypertrophic growth is largely unknown. Objective: This study sought to unveil a pivotal role for transforming factor β-activated kinase 1 (TAK1) coordination Nod-like receptor (NLR) family pyrin domain containing 3 (NLRP3)/Caspase-1/Gasdermin D (GSDMD)-mediated pyroptosis (inflammatory death) under overload. Methods...